富山大学大学院医学薬学研究部応用薬理学研究室

原著論文

2024202320222021202020192018201720162015201420132012201120102009200820072006

2024

1) Ishibashi N, Uta D. Study of analgesic effects of laser irradiation in rats. The Journal of Japan Society for Laser Surgery and Medicine., 44(4):350-359 (2024) doi:10.2530/jslsm.jslsm-44_0045

2) Ishikawa T, Uta D, Okuda H, Potapenko I, Hori K, Kume T, Ozaki N. Combined experiments with in vivo fiber photometry and behavior tests can facilitate the measurement of neuronal activity in the primary somatosensory cortex and hyperalgesia in an inflammatory pain mice model. Biol Pharm Bull., 47(3):591-599 (2024) doi:10.1248/bpb.b23-00700

3) Andoh T, Kikukawa T, Kotani A, Kurokawa Y, Asakura W, Homoto K, Fukutomi D, Uta D, Okai H, Koike K. Combined effect of neurotropin and methylcobalamin on postherpetic neuralgia in mice infected with herpes simplex virus type-1. J Dermatol Sci., 113(3):138-147 (2024) doi:10.1016/j.jdermsci.2024.02.004

4) Uta D. Neural Mechanisms of Fibromyalgia Models. Pain Clinic., 45(3):307-316 (2024)

5) Ohashi N, Uta D, Ohashi M, Hoshino R, Baba H. Omega-conotoxin MVIIA reduces neuropathic pain after spinal cord injury by inhibiting N-type voltage-dependent calcium channels on spinal dorsal horn. Front Neurosci., 18:1366829 (2024) doi:10.3389/fnins.2024.1366829

6) Uta D, Ishibashi N, Tao S, Sawahata M, Kume T. Photobiomodulation inhibits neuronal firing in the superficial but not deep layer of a rat spinal dorsal horn. Biochem Biophys Res Commun., 710:149873 (2024) doi:10.1016/j.bbrc.2024.149873

7) Mori D, Ikeda R, Sawahata M, Yamaguchi S, Kodama A, Hirao T, Arioka Y, Okumura H, Inami C, Suzuki T, Hayashi Y, Kato H, Nawa Y, Miyata S, Kimura H, Kushima I, Aleksic B, Mizoguchi H, Nagai T, Nakazawa T, Hashimoto R, Kaibuchi K, Kume K, Yamada K, Ozaki N. Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice. Transl Psychiatry. , 14(1):138. (2024) doi:10.1038/s41398-023-02679-w

8) Hoshino R, Ohashi N, Uta D, Ohashi M, Deguchi H, Baba H. Actions of Remimazolam on Inhibitory Transmission of Rat Spinal Dorsal Horn Neurons. J Pharmacol Sci., #### (2024) doi:10.1016/j.jphs.2024.04.002

9)

2023

1) Maki T, Sawahata M, Uta D, Irie K, Kume T. Chronic treatment with a toxic conformer of Aβ42 and LPS induces inflammatory responses in BV-2 microglia with dysregulation of hypoxia-inducible factor expression. Biol Pharm Bull., 46(2):359-363 (2023) doi:10.1248/bpb.b22-00855

2) Nunomura S, Uta D, Kitajima I, Nanri Y, Matsuda K, Ejiri N, Kitajima M, Ikemitsu H, Koga M, Yamamoto S, Honda Y, Takedomi H, Andoh T, Conway S, Izuhara K. Periostin links activates distinct modules inflammation and itching downstream of the type 2 inflammation pathway. Cell Rep., in press (2023) doi:10.1016/j.celrep.2022.111933

3) Uta D, Kiyohara K, Nagaoka Y, Kino Y, Fujita T. Developing a Novel Method for the Analysis of Spinal Cord–Penile Neurotransmission Mechanisms. Int J Mol Sci., 24(2):1434 (2023) doi:10.3390/ijms24021434

4) Uta D, Ishibashi N, Konno T, Okada Y, Kawase Y, Tao S, Kume T. Near-infrared photobiomodulation on the peripheral nerve inhibits neuronal firing in a rat spinal dorsal horn evoked by mechanical stimulation. Int J Mol Sci., 24(3):2352 (2023) doi:10.3390/ijms24032352

5) Ueda Y, Uta D, Furue H, Ohtubo Y. An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice. Eur J Pharmacol., 952:175798 (2023) doi:10.1016/j.ejphar.2023.175798

6) Uta D, Takeuchi K, Fukano K, Kawamura H, Ito A. Effect of a single dose of oxaliplatin on the induction of peripheral neuropathy in a rat model: an in vivo electrophysiological study. Biol Pharm Bull., 46(8):1128-1132 (2023)  doi:10.1248/bpb.b23-00263
*J-STAGE Futured Article選出

7) Liao J, Dong G, Zhu W, Wulaer B, Mizoguchi H, Sawahata M, Liu Y, Kaibuchi K, Ozaki N, Nabeshima T, Nagai T, Yamada K. Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia. Pharmacol Res. , 194:106838 (2023)  doi: 10.1016/j.phrs.2023.106838

8) Uta D, Ishibashi N, Konno T, Kawase Y, Tao S, Kume T. Relationship between laser intensity at the peripheral nerve and inhibitory effect of percutaneous photobiomodulation on neuronal firing in a rat spinal dorsal horn. J Clin Med., 12(15):5126 (2023)  doi: 10.3390/jcm12155126

9) Ibi D, Nakasai G, Sawahata M, Takaba R, Kinoshita M, Yamada K, Hiramatsu M. Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone. Pharmacol Biochem Behav., 230:173617 (2023)  doi: 10.1016/j.pbb.2023.173617

10) 歌 大介(Uta D). 神経感作と痒み(Neurosensitization and itching). 皮膚科(Dermatology)., 4(3):287-293 (2023)

11) Taniwa K, Murakami K, Sakaguchi Y, Izuo N, Hanaki M, Sampa N, Kume T, Shimizu T, Irie K. Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation. J Agric Food Chem., 71(39):14289–14299 (2023)  doi: 10.1021/acs.jafc.3c02598

12) Izumi Y, Kataoka H, Takada-Takatori Y, Koyama Y, Irie K, Akaike A, Kume T. Isolation and Purification of Harpagogenin as an Nrf2-ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii). Biol Pharm Bull., 46(11):1576-1582 (2023)  doi: 10.1248/bpb.b23-00383.

2022

1) Derouiche S, Li T, Sakai Y, Uta D, Aoyagi S, Tominaga M. Inhibition of TRPV1 and TRPA1 by mosquito and mouse saliva. Pain., 163(1), 299-307 (2022) doi:10.1097/j.pain.0000000000002337

2) Inami Y, Fukushima M, Kume T, Uta D. Histamine enhances ATP-induced itching and responsiveness to ATP in keratinocytes. J Pharmacol Sci., 148(2), 255-261 (2022) doi:10.1016/j.jphs.2021.12.004

3) Izumi Y, Tasumoto A, Horiuchi N, Arifuku M, Uegomori M, Kume T, Koyama Y. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway. J Pharmacol Sci., 149(1), 1-10 (2022) doi:10.1016/j.jphs.2022.02.004

4) Matsushima Y, Irie Y, Kageyama Y, Bellier JP, Tooyama I, Maki T, Kume T, Yanagita RC, Irie K. Structure optimization of the toxic conformation model of amyloid β42 by intramolecular disulfide bond formation. ChemBioChem., e202200029 (2022) doi:10.1002/cbic.202200029

5) Kiyohara K*, Uta D*, Nagaoka Y, Kino Y, Nonaka H, Ninomiya-Baba M, Fujita T (*authors equally to this work). Involvement of histamine H3 receptor agonism in premature ejaculation found by studies in rats. Int J Mol Sci., 23(4):2291., (2022) doi:10.3390/ijms23042291

6) Ejiri Y, Uta D, Ota H, Mizumura K, Taguchi T. Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. Neurosci Res., S0168-0102(22)00080-3 (2022) doi:10.1016/j.neures.2022.03.005

7) Ohashi N, Uta D, Ohashi M, Baba H. Norepinephrine restores inhibitory tone of spinal lamina X circuitry, thus contributing to analgesia against inflammatory pain. Neuroscience., 490:224-235 (2022) doi:10.1016/j.neuroscience.2022.03.023

8) Ohashi N, Uta D, Ohashi M, Baba H. Analgesic effect of ivabradine against inflammatory pain mediated by hyperpolarization-activated cyclic nucleotide-gated cation channels expressed on primary afferent terminals in spinal dorsal horn. Pain., 63(7):1356-1369 (2022) doi:10.1097/j.pain.0000000000002523

9) Takase S, Liao J, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K. Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. Eur J Pharmacol., 931:175207 (2022) doi:10.1016/j.ejphar.2022.175207

10) Chikugo A, Irie Y, Tsukano C, Uchino A, Maki T, Kume T, Kawase T, Hirose K, Kageyama Y, Tooyama Y, Irie K. Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38. ACS Chem Neurosci., in press (2022) doi: 10.1021/acschemneuro.2c00436

11) Uta D, Inami Y, Fukushima M, Kume T. Light-touch-induced afterdischarge firing in the superficial spinal dorsal horn neurons in hairless mice with irritant contact dermatitis. Biol Pharm Bull., 45(11):1678-1683 (2022)  doi: 10.1248/bpb.b22-00507

  • 表紙イラスト&Highlighted Paper selected by Editor-in-Chief

    12) Uta D, Hattori T, Yamada K, Sawahata M, Kume T, Yoshimura M. Effects of naftopidil on the postsynaptic sensitivity in substantia gelatinosa neurons from lumbosacral spinal cord in rats. The Journal of Functional Diagnosis of the Spinal Cord., 43(1):5-10 (2022)

    13) Yamada K, Uta D, Matsuda K, Sawahata M, Kume T. Effects of various gabapentinoids on paclitaxel-induced peripheral neuropathic pain. The Journal of Functional Diagnosis of the Spinal Cord., 43(1):11-15 (2022)

    14) Maki T, Sawahata M, Akutsu I, Ameike S, Hiramatsu G, Uta D, Izuo N, Shimizu T, Irie K, Kume T. APP knock-in mice produce E22P-Aβ exhibiting an Alzheimer’s disease-like phenotype with dysregulation of hypoxia-inducible factor expression. Int J Mol Sci., 23(21):13259 (2022)  doi: 10.3390/ijms232113259

    2021

    1) Oti T, Satoh K, Uta D, Nagafuchi J, Tateishi S, Ueda R, Takanami K, Young LJ, Galione A, Morris JF, Sakamoto T, Sakamoto H. Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord. Curr Biol., 31(1), 103-114.e5 (2021)

    2) Uta D, Koga K, Furue H, Imoto K, Yoshimura M. L-bupivacaine inhibition of nociceptive transmission in rat peripheral and dorsal horn neurons. Anesthesiology., 134(1), 398-409 (2021)

    3) Hiramatsu G, Uta D, Mihara K, Andoh T, Kume T. Inhibitory effect of panaxytriol on BV-2 microglial cell activation. J Pharmacol Sci., 145(3), 273-278 (2021)

    4) Andoh T, Yoshihisa Y, Rehman MU, Tabuchi Y, Shimizu T. Berberine induces anti-atopic dermatitis effects through the downregulation of cutaneous EIF3F and MALT1 in NC/Nga mice with atopy-like dermatitis. Biochem Pharmacol., 185:114439 (2021)

    5) Uta D, Oti T, Sakamoto T, Sakamoto H. In vivo electrophysiology of peptidergic neurons in deep layers of the lumbar spinal cord after optogenetic stimulation of hypothalamic paraventricular oxytocin neurons in rats. Int J Mol Sci., 22(7):3400 (2021)

    6) Hiramatsu G, Matsuda K, Uta D, Mihara K, Kume T. Panaxytriol inhibits lipopolysaccharide-induced microglia activation in brain inflammation in vivo. Biol Pharm Bull., 44(7):1024-1028 (2021)

    7) Kiguchi N, Fukazawa Y, Saika A, Uta D, Saika F, Nakamura T, Ko M, Kishioka S. PChemogenetic activation of central GRP-expressing neurons elicits itch-related scratching behavior in male and female mice. Pharmacol Res Perspect., (3):e00790 (2021)

    8) Sawahata M, Izumi Y, Akaike A, Kume T. In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae. Brain Res Bull., 173, 45-52 (2021)

    9) Takanami K, Uta D, Matsuda KI, Kawata M, Carstens E, Sakamoto T, Sakamoto H. Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons. Proc Natl Acad Sci U S A., 118(31):e2103536118 (2021)

    10) Matsumoto M, Miyamoto M, Sawahata M, Izumi Y, Takeda-Takatori Y, Kume T. Establishing a high throughput drug screening system for cerebral ischemia using zebrafish. J Pharmacol Sci., 147(1):138-142 (2021)

    11) Sawahata M, Asano H, Nagai T, Ito N, Kohno T, nabeshima T, Hattori M, Yamada K. Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice. Pharmacol Res., 173:105832 (2021)

    12) Uta D, Hattori T, Yoshimura M. Analyses of the mode of action of an alpha-adrenoceptor blocker in substantia gelatinosa neurons in rats. Int J Mol Sci., 22(17):9636 (2021)

    13) Uta D, Tsuboshima K, Nishijo H, Mizumura K, and Taguchi T. Neuronal sensitization and synaptic facilitation in the superficial dorsal horn of a rat reserpine-induced pain model. Neuroscience., S0306-4522(21)00512-1 (2021)

    14) Kato H, Sato H, Okuda M, Wu J, Koyama S, Izumi Y, Waku T, Iino M, Aoki M, Arawaka S, Ohta Y, Ishizawa K, Kawasaki K, Urano Y, Miyasaka T, Noguchi N, Kume T, Akaike A, Sugimoto H, Kato T. Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener., 11:1-7 (2021)

    15) Uta D, Yamada K, Matsuda K, Kume T, Imoto K, Furue H. Actions of local anesthetics in rat spinal dorsal horn neurons by using in vivo patch clamp recording. The Journal of Functional Diagnosis of the Spinal Cord., 42(1):3-8 (2021)

    16) Matsuda K, Uta D, Yamada K, Kume T. Electrophysiological and behavioral analysis of a mouse model of atopic dermatitis. The Journal of Functional Diagnosis of the Spinal Cord., 42(1):9-14 (2021)

    17) Yamada K, Uta D, Matsuda K, Kume T. Behavior and electrophysiology studies of the peripheral neuropathy induced by paclitaxel in mouse. The Journal of Functional Diagnosis of the Spinal Cord., 42(1):15-19 (2021)

    2020

    1) Taguchi K, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Protective Effect of 2',3'-Dihydroxy-4',6'-dimethoxychalcone on Glutamate-Induced Neurotoxicity in Primary Cortical Cultures. Biol Pharm Bull., 43(1), 184-187 (2020)

    2) Inami Y, Uta D, Andoh T. Neuronal hyperexcitability and astrocyte activation in spinal dorsal horn of a dermatitis mouse model with cutaneous hypersensitivity. Neurosci Lett., 720:134784 (2020)

    3) Uta D, Hattori T, Yoshimura M. Effect of alpha 1-adrnoceptor antagonists on postsynaptic sensitivity in substantia gelatinosa neurons from lumbo-sacral spinal cord in rats using slice patch-clamp technique for mEPSC. Int Neurourol J., 24(2), 135-143 (2020)

    4) Kiguchi N, Uta D, Ding H, Uchida H, Saika F, Matsuzaki S, Fukazawa Y, Abe M, Sakimura K, Ko MC, Kishioka S. GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn. Neuropharmacology., 170:108025 (2020)

    5) Mizawa M, Andoh T, Shimizu T. Gardenia Fruit-Related Blue-Gray Skin Pigmentation. JAMA Dermatol., in press (2020)

    6) Murakami K, Yoshimura M, Nakagawa S, Kume T, Kondo T, Inoue H, Irie K. Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator. Int J Mol Sci., 21(4), 1179 (2020)

    7) Ueda Y, Uta D, Tanbo S, Kawabata K, Kanayama S, Osaki M, Nozawa N, Matsumoto T, Andoh T. Inhibitory effect of amenamevir on acute herpetic pain and postherpetic neuralgia in mice infected with herpes simplex virus-1. J Dermatol Sci., 21(4), 1179 (2020)

    8) Uta D, Hattori T, Yoshimura M. Differential effects of alpha 1-adrenoceptor antagonists on the postsynaptic sensitivity: Using slice patch-clamp technique for IPSC in substantia gelatinosa neurons from lumbo-sacral spinal cord in rats. Int Neurourol J., 24(2), 127-134 (2020)

    9) Nishino R, Aoyagi S, Suzuki M, Ueda A, Okumura Y, Takahashi T, Hosomi R, Fukunaga K, Uta D, Takazawa T, and Fujii T. Development of Artificial Skin Using Keratin Film for Evaluation of Puncture Performance of Microneedle. Journal of Robotics and Mechatronics., 32(2), 351-361 (2020)

    10) Uta D, Andoh T, Kume T, Yoshimura M, Koga K. Chronic pain rat models enhance spontaneous glutamatergic transmission on spinal dorsal horn. The Journal of Functional Diagnosis of the Spinal Cord., in press (2020)

    11) Delgado-Wicke P, Rodríguez-Luna A, Ikeyama Y, Honma Y, Kume T, Gutierrez M, Lorrio S, Juarranz Á, González S. Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes From PM 2.5-Induced Xenotoxic Stress. Oxid Med Cell Longev., 2020:2908108 (2020)

    12) Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y. Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus. Biol Pharm Bull., 43(7), 1111-1117 (2020)

    13) Inose Y, Izumi Y, Takada-Takatori Y, Akaike A, Koyama Y, Kaneko S, Kume T. Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1. Neurosci Lett., in press (2020)

    14) Murakami K, Yamaguchi T, Izuo N, Kume T, Hara H, Irie K. Synthetic and biophysical studies on the toxic conformer in amyloid β with the E22Δ mutation in Alzheimer pathology. ACS Chem Neurosci., in press (2020)

    15) Yu H, Toume K, Kurokawa Y, Andoh T, Komatsu K. Iridoids isolated from Viticis Fructus inhibit paclitaxel-induced mechanical allodynia in mice. J Nat Med., in press (2020)

    16) Nakata T, Doi A, Uta D, Yoshimura M, Shin MC. Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. PLoS One., 15(9):e0239473 (2020)

    17) Nakata T, Doi A, Uta D, Shin MC, Yoshimura M. Free gait in a shallow pool accelerates recovery after exercise in model mice with fibromyalgia. J Exerc Rehabil., 16(5), 398-409 (2020)

    2019

    1) Li S, Andoh T, Zhang Q, Uta D, Kuraishi Y. β2-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B4 and thromboxane A2) are involved in chronic renal failure-associated itch-associated responses in mice. Eur J Pharmacol., 847, 19-25 (2019)

    2) Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y. Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells. Front Pharmacol., 10:59 (2019)

    3) Uta D, Kato G, Doi A, Andoh T, Kume T, Yoshimura M, Koga K. Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo. Biochem Biophys Res Commun., 512(2), 352-359 (2019)

    4) Uta D, Hattori T, Yoshimura M. Characterization on responsiveness of excitatory synaptic transmissions to α1-adrenoceptor blockers in substantia gelatinosa neurons isolated from lumbo-sacral level in rat spinal cords. Int Neurourol J., 23(1), 13-21 (2019)

    5) Sonohata M, Doi A, Yasaka T, Uta D, Mawatari M, Yoshimura M. Noradrenaline modulates mechanically evoked responses in the rat spinal dorsal horn: an in vivo patch-clamp study. J Pain Res., 12, 1269-1278 (2019)

    6) Andoh T, Fukutomi D, Uta D, Kuraishi Y. Prophylactic repetitive treatment with the herbal medicine Kei-kyoh-zoh-soh-oh-shin-bu-toh attenuates oxaliplatin-induced mechanical allodynia by decreasing spinal astrocytes.  Evid. Based Complement Alternat Med., (2019)

    7) Uta D, Hattori T, Andoh T, Kume T, Yoshimura M. Effects of Naftopidil on primary afferent fiber evoked excitatory postsynaptic transmission in adult rat substantia geratinosa neuron. The Journal of Functional Diagnosis of the Spinal Cord. , in press (2019)

    8) Toume K, Hou Z, Yu H, Kato M, Maesaka M, Bai Y, Hanazawa S, Ge Y, Andoh T, Komatsu K. Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula "Goshajinkigan". J Nat Med., 73(4), 761-768 (2019)

    9) Andoh T, Akasaka C, Shimizu K, Lee JB, Yoshihisa Y, Shimizu T. Involvement of α-Melanocyte-Stimulating Hormone-Thromboxane A2 System on Itching in Atopic Dermatitis. Am J Pathol., 189(9), 1775-1785 (2019)

    10) Shimizu K, Andoh T, Makino T, Yoshihisa Y, Mizawa M, Shimizu T. Mechanisms of itching in mycosis fungoides: grade of itching correlates with eosinophil infiltration and kallikrein 5 expression. Eur J Dermatol., 29(3), 268-273 (2019)

    11) Takada-Takatori Y, Nakagawa S, Kimata R, Nao Y, Mizukawa Y, Urushidani T, Izumi Y, Akaike A, Tsuchida K, Kume T. Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons. Sci Rep., 9(1), 11922 (2019)

    12) Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y, Kunimura K, Kamikaseda Y, Furue M, Fukui Y. Selective role of neurokinin B in IL-31-induced itch response in mice. J Allergy Clin Immunol., 144(4):1130-1133 (2019)

    13) Iwasaki M, Izuo N, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons. Biol Pharm Bull., 42(11):1942-1946 (2019)

    14) Takada-Takatori Y, Tomii Y, Takemasa S, Takeda Y, Izumi Y, Akaike A, Tsuchida K, Kume T. Protective effects of 2'-3'-dihydroxy-4',6'-dimethoxychalcone derived from green perilla leaves against UV radiation-induced cell injury in human cultured keratinocytes. Biol Pharm Bull., 9(1):11922 (2019)

    15) Uta D, Yoshimura M, Koga K. Chronic pain models amplify transient receptor potential vanilloid 1 (TRPV1) receptor responses in adult rat spinal dorsal horn. Neuropharmacology., 160:107753 (2019)

    16) Nakagawa S, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Increased CCL6 expression in astrocytes and neuronal protection from neuron–astrocyte interactions. Biochem Biophys Res Commun., 519(4):777-782 (2019)

    17) Taguchi K, Izumi Y, Takada-Takatori Y, Akaike A, Kume T. Protective effect of 2',3'-dihydroxy-4',6'-dimethoxychalcone on glutamate-induced neurotoxicity in primary cortical cultures. Biol Pharm Bull., in press (2019)

    18) Yamamoto K, Izumi Y, Arifuku M, Kume T, Sawada H. α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP3 receptor. Sci Rep., in press (2019)

    19) Yamamoto S, Aoyagi S, Yamada M, Takahashi T, Suzuki M, Nagashima T, Kunugi A, Chiyonobu M, Kuroiwa T, Hosomi R, Fukunaga K, Uta D, Takazawa T, Hikitsuchi T, Kawajiri Y, Nakayama K. A puncturing device that mimics the mechanism of mosquito's proboscis and labium -Verification of the effect of skin deformation/needle buckling prevention mechanism and puncture experiment on artificial skin and experimental animals-. Int. J. of Automation Technology., in press (2019)

    20) Yoshihisa Y, Andoh T, Rehman MU, Shimizu T. The regulation of protein kinase casein kinase II by apigenin is involved in the inhibition of ultraviolet B-induced macrophage migration inhibitory factor-mediated hyperpigmentation. Phytother Res., in press (2019)

    2018

    1) Izumi Y, Kataoka H, Inose Y, Akaike A, Koyama Y, Kume, T. Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons. Eur J Pharmacol., 818, 470-479 (2018)

    2) Andoh T, Li S, Uta D. Involvement of thromboxane A2 in interleukin-31-induced itch-associated response in mice. Pharmacol Rep., 70(2), 251-257 (2018)

    3) Andoh T, Asakawa Y, Kuraishi Y. Non-myelinated C-fibers, but not myelinated A-fibers, elongate into the epidermis in dry skin with itch. Neurosci Lett., 672, 84-89 (2018)

    4) Yoshino O, Yamada-Nomoto K., Kobayashi M., Andoh T., Hongo M., Ono Y., Hasegawa-Idemitsu A., Sakai A., Osuga Y., Saito S. Bradykinin system is involved in endometriosis-related pain through endothelin-1 production. Eur. J. Pain., 22, 501-510 (2018)

    5) Akiyama T, Andoh T, Ohtsuka E, Nojima H, Ouchi H, Takahata H, Kuraishi Y. Peripheral gabapentin regulates mosquito allergy-induced itch in mice. Eur J Pharmacol., 833, 44-49 (2018)

    6) Shinohara A, Andoh T, Saiki I, Kuraishi Y. Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice. Eur J Pharmacol., 833, 275-278 (2018)

    7) Uta D, Hattori T, Kasahara KI, Yoshimura M. Effects of naftopidil in substantia gelatinosa neurons of the adult rat spinal dorsal horn. The Journal of Functional Diagnosis of the Spinal Cord., 39(1):7-13, 2018

    8) Ikeguchi S, Izumi Y, Kitamura N, Kishino S, Ogawa J, Akaike A, Kume T. Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation. J Pharmacol Sci., 138(1), 9-15 (2018)

    9) Maeda S, Andoh T, Onishi R, Tomoyasu Y, Higuchi H, Miyawaki T. Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis. J Anesth., 32(5), 731-739 (2018)

    10) Kagoyama K, Andoh T, Shimizu T. Enlarging the irradiation spot to include the edge of hyperkeratotic papules using a CO2 surgical laser dramatically improves the treatment of lichen amyloidosus. Eur J Dermatol., 28(6):837-839 (2018)

    11) Shiratori-Hayashi M, Hasegawa A, Toyonaga H, Andoh T, Nakahara T, Kido-Nakahara M, Furue M, Kuraishi Y, Inoue K, Dong X, Tsuda M. Role of P2X3 receptors in scratching behavior in mouse models. J Allergy Clin Immunol., 143(3):1252-1254 (2018)

    12) Uta D, Hattori T, Yoshimura M. Effects of high concentration of naftopidil on dorsal root evoked excitatory synaptic transmission in substantia gelatinosa neurons of the rat spinal dorsal horn in vitro. Int Neurourol J., 22(4):252-259 (2018)

    2017年以前の久米の業績はこちらを参照ください。

    2017

    1) Uta D, Xie DJ, Hattori T, Kasahara KI, Yoshimura M. Effects of naftopidil on inhibitory transmission in substantia gelatinosa neurons of the rat spinal dorsal horn in vitro. J Neurol Sci. 2017 Sep; 380: 205-11.

    2) Andoh T, Maki T, Li S, Uta D. β2-Microglobulin elicits itch-related responses in mice through the direct activation of primary afferent neurons expressing transient receptor potential vanilloid 1. Eur J Pharmacol. 2017 Sep; 810: 134-40.

    3) Andoh T, Harada A, Kuraishi Y. Involvement of leukotriene B4 released from keratinocytes in itch-associated response to intradermal interleukin-31 in mice. Acta Derm Venereol. 2017 Aug; 97(8): 922-7.

    4) Ohashi N, Uta D, Sasaki M, Ohashi M, Kamiya Y, Kohno T. Acetaminophen metabolite N-acylphenolamine induces analgesia via transient receptor potential vanilloid 1 receptors expressed on the primary afferent terminals of C-fibers in the spinal dorsal horn. Anesthesiology 2017 Aug; 127(2): 355-71.

    5) Inami Y, Sato A, Ohtsu H, Mano Y, Sasaki A, Kuraishi Y, Andoh T. Deficiency of histidine decarboxylase attenuates peripheral nerve fibre elongation into the epidermis in surfactant-treated mouse skin. Exp Dermatol. 2017 May; 26(5): 441-3.

    6) Andoh T, Kobayashi N, Uta D, Kuraishi Y. Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A1 receptors. Phytomedicine 2017 Feb: 1-7.

    7) Andoh T, Shinohara A, Kuraishi Y. Inhibitory effect of fentanyl citrate on therelease of endothlin-1 induced by bradykinin in melanoma cells. Pharmacol Rep. 2017 Feb; 69(1): 139-42.

    8) Andoh T, Uta D, Kato M, Toume K, Komatsu K, Kuraishi Y. Prophylactic administration of aucubin Inhibits paclitaxel-induced mechanical allodynia via the inhibition of endoplasmic reticulum stress in peripheral Schwann cells. Biol Pharm Bull. 2017; 40(4): 473-8.

    9) Andoh T, Mizoguchi S, Kuraishi Y. Shakuyakukanzoto attenuates oxaliplatin-induced cold dysesthesia by inhibiting the expression of transient receptor potential melastatin 8 in mice. J Tradit Complement Med. 2016 Feb; 7(1): 30-3.

    10) Andoh T, Shimizu T. Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis. Br J Dermatol. 2017 Oct; 177(4): e143-e144. doi: 10.1111/bjd.15488.

    11) 歌 大介,井本敬二,古江秀昌.ラット脊髄後角膠様質細胞への侵害受容シナプス伝達に対するTRPA1チャネル作動薬の応答解析-In vitro及びin vivoパッチクランプ解析を用いて-.Pain Res. 2017; 32(3): 179-90.

    12) 歌 大介,井本敬二,古江秀昌.Actions of local anesthetics of voltage-gated Na channels in adult rat dorsal root ganglion neurons.The Journal of Functional Diagnosis of the Spinal Cord(脊髄機能診断研究会誌)2017 Jan; 37(1): 4-10.

    13) Uta D, Taguchi T.Peripheral and spinal mechanisms of nociceptive transmission in a rat model of fibromyalgia.Pain Res. 2017; 32(4): 280-287.

    2016

    1) Andoh T, Kato M, Kitamura R, Mizoguchi S, Uta D, Toume K, Komatsu K, Kuraishi Y. Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice. J Tradit Complement Med. 2016 Jan 2; 6(3): 305-8.

    2) Sakamoto A*, Andoh T, Kuraishi Y. Involvement of mast cells and proteinase-activated receptor 2 in oxaliplatin-induced mechanical allodynia in mice. Pharmacol Res. 2016 Mar; 105: 84-92.

    3) Yoshihisa Y, Andoh T, Matsunaga K, Rehman MU, Maoka T, Shimizu T. Efficacy of astaxanthin for the treatment of atopicdermatitis in a murine model. PLoS One. 2016 Mar 29; 11(3): e0152288.

    4) Andoh T, Kobayashi N, Kuraishi Y. Prophylactic repetitive administration of shakuyakukanzoto inhibits paclitaxel-induced mechanical allodynia in mice via peripheral effects. Trad Kamp Med. 2016 Apr; 3(1): 71-4.

    5) Mizoguchi S*, Andoh T, Yakura T, Kuraishi Y. Involvement of c-Myc-mediated transient receptor potential melastatin 8 expression in oxaliplatin-induced cold allodynia in mice. Pharmacol Rep. 2016 Jun; 68(3): 645-8.

    6) Akiguchi S, Ishida H, Takada Y, Teranishi T, Andoh T, Hachiga T. Examining the relationship between blood flow velocity and movement of erythrocytes in a capillary using laser doppler velocimetry. IEEJ Trans. 2016 Jul; 11(4): 451-6.

    7) Andoh T, Sakamoto A, Kuraishi Y. 5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice. J Pharmacol Sci. 2016 Aug; 131(4): 284-7.

    8) Kyoden T, Shoji N, Akiguchi S, Ishida H, Andoh T, Takada Y, Momose N, Homae T, Hachiga T. In vivo visualization method by absolute velocity based on speckle and fringe pattern using two-beam multipoint laser Doppler velocimetry. J Appl Phys. 2016 Aug; 120: 084701(1)-(6).

    9) Kagaya K*, Sasaki A, Kino Y, Taniguchi H, Kuraishi Y, Andoh T. Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion. Neurosci Lett. 2016 Sep 19; 631: 109-14.

    10) Andoh T, Yamamoto A, Haza S, Yuhki K, Ushikubi F, Narumiya S, Kuraishi Y. Thromboxane A2 is involved in itch-associated responses in mice with atopic dermatitis-like skin lesions. Acta Derm Venereol. 2016 Nov 2; 96(7): 899-904.


    2015

    1) Andoh T, Kitamura R, Kuraishi Y. Milnacipran inhibits oxaliplatin-induced mechanical allodynia through spinal action in mice. Biol Pharm Bull. 2015; 38(1): 151-4.

    2) Kyoden T, Yasue Y, Ishida H, Akiguchi S, Andoh T, Takada Y, Teranishi T, Hachiga T. Multi-channel LDV measurement technique using a two-dimensional optical fiber array for obtaining instantaneous velocity distribution characteristics. Jpn J Appl Phys. 2015 Jan; 54(1): 012501.

    3) Kee JY, Inujima A, Andoh T, Tanaka K, Li F, Kuraishi Y, Sakurai H, Shibahara N, Saiki I, Koizumi K. Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation. J Nat Med. 2015 Apr; 69(2): 209-17.

    4) Ebisawa S*, Andoh T, Shimada Y, Kuraishi Y. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evid Based Complement Alternat Med. 2015;2015: 870687.

    5) Ishida H, Andoh T, Akiguchi S, Kyoden T, Hachiga T. Observation of tumor microvessels that are controlled by blood flow in breast cancer. Appl Phys Lett. 2015; 106: 173703.

    6) Kyoden T, Abe S, Ishida H, Akiguchi S, Andoh T, Takada Y, Teranishi T, Hachiga T. High-resolution in-situ LDV monitoring system for measuring velocity distribution in blood vessel. Opt Commun. 2015 Oct 15; 353: 122-32.

    7) Shimizu K, Andoh T, Yoshihisa Y, Shimizu T. Histamine Released from Epidermal Keratinocytes Plays a Role inα-Melanocyte-Stimulating Hormone-Induced Itching in Mice. Am J Pathol. 2015 Nov; 185(11): 3003-10.

    8) Andoh T, Tsujii K, Kuraishi Y. Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis. Exp Dermatol. 2015 Dec; 24(12): 978-80.

    9) Takayama Y, Uta D, Furue H, Tominaga M. Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16): 5213-8.

    10) Kase D, Uta D, Ishihara H, Imoto K. Inhibitory synaptic transmission from the substantia nigra pars reticulata to the ventral medial thalamus in mice. Neurosci Res. 2015 Aug; 97: 26-35.

    11) Tonomura S, Ebara S, Bagdasarian K, Uta D, Ahissar E, Meir I, Lampl I, Kuroda D, Furuta T, Furue H, Kumamoto K. Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like endings, a vibrissal mechanoreceptor. Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(10): 560-76.

    12) Uta D, Yoshimura M, Imoto K, Furue H. Action of TRPA1 agonists on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord. The Journal of Functional Diagnosis of the Spinal Cord. 2015; 36(1): 5-11.

    2014

    1) Kitamura R, Andoh T, Mizoguchi S, Saito Y, Takahata H, Kuraishi Y. Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice. J Pharmacol Sci. 2014 ;124(4): 502-10.

    2) Funai Y, Pickering AE, Uta D, Nishikawa K, Mori T, Asada A, Imoto K, Furue H. Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control:an in vivo patch-clamp analysis of analgesic mechanisms. Pain. 2014 Mar ;155(3): 617-28.

    3) Kawai J, Andoh T, Ouchi K, Inatomi S. Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice. Evid Based Complement Alternat Med. 2014; 2014:532389.

    4) Andoh T, Yoshida T, Kuraishi Y. Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch-related responses in mice with chronic atopy-like dermatitis. Exp Dermatol. 2014 May; 23(5): 359-61.

    5) Ishida H, Yasue Y, Hachiga T, Andoh T, Akiguchi S, Kuraishi Y, Shimizu T. Power spectrum and blood flow velocity images obtained by dual-beam backscatter laser Doppler velocimetry. Opt Rev. 2014 Jul; 21(4): 461-7.

    6) Andoh T, Takayama Y, Kuraishi Y. Involvement of leukotriene B4 in dermatophyte-related itch in mice. Pharmacol Rep. 2014 Aug; 66(4): 699-703.

    7) Nishida K, Matsumura S, Taniguchi W, Uta D, Furue H, Ito S. Three-dimensional distribution of sensory stimulation-evoked neuronal activity of spinal dorsal horn neurons analyzed by in vivo calcium imaging.PLoS One. 2014 Aug 6; 9(8): e103321.

    8) Andoh T, Kitamura R, Fushimi H, Komatsu K, Shibahara N, Kuraishi Y. Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by Paclitaxel in mice. J Tradit Complement Med. 2014 Oct; 4(4): 293-7.

    9) Inami Y, Sasaki A, Andoh T, Kuraishi Y. Surfactant-induced chronic pruritus: Role of L-histidine decarboxylase expression and histamine production in epidermis. Acta Derm Venereol.2014 Nov; 94(6): 645-50.

    10) Sasaki A, Mizoguchi S, Kagaya K, Shiro M, Sakai A, Andoh T, Kino Y, Taniguchi H, Saito Y, Takahata H, Kuraishi Y. A mouse model of peripheral postischemic dysesthesia: involvement of reperfusion-induced oxidative stress and TRPA1 channel. J Pharmacol Exp Ther. 2014 Dec; 351(3): 568-75.

    11) Andoh T, Kuraishi Y. Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: Inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP. J Dermatol Sci. 2014 Dec; 76(3): 206-13.

    2013

    1) Inami Y, Andoh T, Sasaki A, Kuraishi Y. Topical surfactant-induced pruritus: involvement of histamine released from epidermal keratinocytes. J Pharmacol Exp Ther. 2013;344:459-66.

    2) Sasaki A, Inomata Y, Serizawa K, Andoh T, Kuraishi Y. Contribution of sensory C-fiber neuron injury to mechanical dynamic allodynia in a murine model of postherpetic neuralgia. Neuroreport. 2013;24:137-41.

    3) Inomata Y, Gouda M, Kagaya K, Yamagami K, Sasaki A, Andoh T, Kuraishi Y. Association of denervation severity in the dermis with the development of mechanical allodynia and hyperalgesia in a murine model of postherpetic neuralgia. Anesth Analg. 2013;116:722-9.

    4) Inami Y, Andoh T, Kuraishi Y. Prevention of topical surfactant-induced itch-related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis. J Pharmacol Sci. 2013;121:242-5.

    5) Akiguchi S, Ishida H, Andoh T, Shimizu T, Kuraishi T, Yasuda Y, Hachiga T. Application of a Micro Multipoint Laser Doppler Velocimeter for in vivo evaluation of subcutaneous blood flow. IEEJ Trans. 2013;8:652-3.

    6) Sasaki A, Adhikari S, Andoh T, Kuraishi Y. BB2 bombesin receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling. Neuroreport. 2013;24:652-6.

    7) Yamakoshi T, Andoh T, Makino T, Kuraishi Y, Shimizu T. Clinical and histopathological features of itch in patients with alopecia areata. Acta Derm Venereol. 2013;93:575-6.

    8) Bahar MA, Andoh T, Ogura K, Hayakawa Y, Saiki I, Kuraishi Y. Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel. Evid Based Complement Alternat Med. 2013;2013:849754.

    9) Andoh T, Gotoh Y, Kuraishi Y. Milnacipran inhibits itch-related responses in mice through the enhancement of noradrenergic transmission in the spinal cord. J Pharmacol Sci. 2013;123:199-202.

    10) Andoh T, Sakamoto A, Kuraishi Y. Effects of xaliproden, a 5-HT1A agonist, on mechanical allodynia caused by chemotherapeutic agents in mice. Eur J Pharmacol. 2013;721:231-6.

    11) Kitamura R, Andoh T, Fushimi H, Komatsu K, Shibahara N, Kuraishi Y. Involvement of descending monoaminergic systems in antiallodynic effect of goshajinkigan in oxaliplatin-treated mice. J Trad Med. 2013;30:183-9.

    12) 高田洋吾,寺西恒宣,石田弘樹,秋口俊輔,安東嗣修,八賀正司.レーザードップラー流速分布測定装置の生体計測への応用(皮膚癌の早期血流画像診断).日本機械学会論文集(B1 編).2013;79(802):2013-6.

    2012

    1) Takasaki I., Taniguchi K., Komatsu F., Sasaki A., Andoh T., Nojima H., Shiraki K., Hsu D.K., Liu F.-T., Kato I., Hiraga K., and Kuraishi Y. : Contribution of spinal galectin-3 to acute herpetic allodynia in mice. Pain, 153: 585-592, 2012.

    2) Ishida H., Andoh T., Akiguchi S., Hachiga T., Ishizuka M., Shimizu T., Shirakawa H., and Kuraishi Y. : Noninvasive in-vivo measurements of microvessels by reflection-type micro multipoint laser doppler velocimeter. Jpn. J. Appl. Phys. , 51: 032701 (1)-032701 (5), 2012.

    3) Akiguchi S., Ishida H., Andoh T., Hachiga T., Shimizu T., Kuraishi Y., Shirakawa H., and Ueyama K. : Measurement of blood flow velocity in a model of stenosis in vitro and in mesenteric vessels in vivo using non-invasive micro multipoint laser Doppler velocimetry. Meas. Sci. Technol. , 23: 045702 (1)-045702 (8), 2012.

    4) Andoh T., Sakai K., Urashima M., Kitazawa K., Honma A., and Kuraishi Y. : Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp. Eye Res. 98: 97-103, 2012.

    5) Andoh T., Yoshida T., Lee J.B., and Kuraishi Y. : Cathepsin E induces itch-related response through the production of endothelin-1 in mice. Eur. J. Pharmacol. , 686: 16-21, 2012.

    6) Unezaki S., Sasaki A., Mabuchi T., Matsumura S., Katano T., Nishio N., Andoh T., Nakazawa T., Yamamoto T., Nakatska T., Kuraishi Y., and Ito S. : Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice. Mol. Pain , 8: 59, 2012.

    7) Andoh T., Takayama Y., Yamakoshi T., Lee J.B., Sano A., Shimizu T., and Kuraishi Y. : Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J. Pharmacol. Exp. Ther. , 343: 91-96, 2012.

    8) Ishida H., Hachiga T., Andoh T., and Akiguchi S. : In-vivo visualization of melanoma tumor microvessels and blood flow velocity changes accompanying tumor growth. J. Appl. Phys. , 112: 104703(1)-104703(7), 2012.

    9) Ozawa T., Piao X., Kobayashi E., Zhou Y., Sakurai H., Andoh T., Jin A., Kishi H., and Muraguchi A. : A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity. PLoS One , 7: e52383, 2012.

    2011

    1) Gotoh Y., Andoh T., and Kuraishi Y. : Clonidine inhibits itch-related response through stimulation of α2-adrenoceptors in the spinal cord in mice. Eur. J. Pharmacol., 650: 215-219, 2011.

    2) Gotoh Y., Omori Y., Andoh T., and Kuraishi Y. : Tonic inhibition of allergic itch signaling by the descending noradrenergic system in mice. J. Pharmacol. Sci., 115: 417-420, 2011.

    3) 安東嗣修,野口 悦,倉石 泰,竜 瑞之:速乾性液状手指消毒剤「ウィル・ステラ V」の抗菌作用および皮膚への影響に関する検討.医学と薬学,65:403-409,2011.

    4) Gotoh Y., Andoh T., and Kuraishi Y. : Noradrenergic regulation of itch transmission in the spinal cord mediated by α-adrenoceptors.Neuropharmacol., 61: 825-831, 2011.

    5) Ishida H., Kobayashi D., Shirakawa H., Andoh T., Akiguchi S., Wakisaka T., Ishizuka M., and Hachiga T. : Reflection-type micro multipoint laser Doppler velocimeter for measuring velocity distributions in blood vessels. Rev. Sci. Intrum., 87: 076104-1-3, 2011.

    6) Andoh T., Haza S., Saito A., and Kuraishi Y. : Involvement of leukotriene B4 in spontaneous itch-related behavior in NC mice with atopic dermatitis-like skin lesions. Exp. Dermatol., 20: 894-898, 2011.

    7) Andoh T., Kuwazono T., Lee JB, and Kuraishi Y. : Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice.Peptides, 32: 2098-2103, 2011.

    2010

    1) Fujita M., Andoh T., Ohashi K., Akira A., Saiki I., and Kuraishi Y.: Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice. Eur. J. Pain , 14: 588-594, 2010.

    2) Andoh T., Akira A., Saiki I., and Kuraishi Y.: Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells. Peptides , 31: 238-241, 2010.

    3) Nishikawa Y., Sasaki A., and Kuraishi Y.: Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic andstatic mechanical allodynia in mice with herpetic or postherpetic pain. J. Pharmacol. Sci. , 112: 352-360, 2010.

    4) Fujita M., Andoh T., Sasaki A., Saiki I., and Kuraishi Y.: Involvement of peripheral adenosine 5'-triphosphate and P2X purinoceptor in pain-related behavior produced by orthotopic melanoma inoculation in mice. Eur. J. Neurosci. , 31: 1629-1636,2010.

    5) Zhang Q., Andoh T., Konno M., Lee J.B., Hattori M., and Kuraishi Y.: Inhibitory effect of methanol extract of Ganodermalucidum on acute itch-associated responses in mice. Biol. Pharm. Bull. , 33: 909-911, 2010.

    6) Ishida H., Andoh T., Aiguchi S., Shirakawa H., Kobayashi D., Kuraishi Y., and Hachiga T.: Blood flow velocity imaging of malignant melanoma by micro multi-point laser doppler velocimetry. Appl. Phys. Lett. , 97: 103702(1)-103702(3), 2010.

    7) Andoh T., Zhang Q., Yamamoto T., Tayama M., Hattori M., Tanaka K., Kuraishi Y.: Inhibitory effects of methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice. J. Pharmacol. Sci. , 114: 292-297, 2010.

    8) Yoshinaga K., Horii T., Hamano H., Eta R., Ozaki T., Orikawa Y., Yoshii K., Kawabata Y., Hori Y., Seto K., Takei M., and Kuraishi Y.: Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain. Biol. Pharm. Bull. , 33: 244-248, 2010.

    2009

    1) Andoh T., Ishida H., Akiguchi S., Shirakawa H., Kuraishi Y., and Hachiga T.: High resolution in-vivo 3-D mapping of blood flow and blood vessels by using advanced multi-point Laser Doppler Velocimeter. Jpn. J. Appl. Phys., 48: 017002-1-017002-5, 2009.

    2) Omori Y.*, Andoh T., Shirakawa H., Ishida H., Hachiga T., and Kuraishi Y.: Itch-related responses of dorsal horn neurons to cutaneous allergic stimulation in mice. Neuroreport, 20: 478-481, 2009.

    3) Tsujii K.*, Andoh T., Ui H., Lee J.B., and Kuraishi Y.: Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis. J. Pharmacol. Sci., 109: 388-395, 2009.

    4) Gauchan P.*, Andoh T., Kato A., Sasaki A., and Kuraishi Y.: Effects of prostaglandin E1 analog limaprost on mechanical allodynia caused by chemotherapeutic agents in mice. J. Pharmacol. Sci., 109: 469-472, 2009.

    5) Gauchan P.*, Andoh T., Ikeda K., Fujita M., Sasaki A., Kato A., and Kuraishi Y.: Mechanical allodynia induced by paclitaxel, oxaliplatin and vincristine: different effectiveness of gabapentin and different expression of voltage-dependent calcium channel α2δ-1 subunit. Biol. Pharm. Bull., 32: 732-734, 2009.

    6) Omori Y.*, Kagaya K., Enomoto R., Sasaki A., Andoh T., Nojima H., Takahata H., and Kuraishi Y.: A mouse model of sural nerve injury-induced neuropathy: gabapentin inhibits pain-related behaviors and the hyperactivity of wide dynamic range neurons in the dorsal horn. J. Pharmacol. Sci., 109: 532-539, 2009.

    7) Gauchan P.*, Andoh T., Kato A., and Kuraishi Y.: Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice. Neurosci. Lett., 458: 93-95, 2009.

    8) Andoh T., Saito A., and Kuraishi Y.: Leukotriene B4 mediates sphingosylphosphorylcholine-induced itch-associated responses in the mouse skin. J. Invest. Dermatol., 129: 2854-2860, 2009.

    9) Nakatsuka I., Maeda S., Andoh T., Hayashi Y., Mizuno R., Higuchi H., and Miyawaki T.: Oxidative changes in the rat brain by intraperitoneal injection of ferric nitrilotriacetate. Rexdox report, 14: 109-114, 2009.

    10) Nishikawa Y.*, Sasaki A., Andoh T., Nojima H., Shiraki K., and Kuraishi Y.: Modality-specific hyperexcitability of dorsal horn neurons to mechanical stimuli in herpetic mice. Neuroreport, 20: 1077-1080, 2009.

    11) Ishida H., Shirakawa H., Andoh T., Akiguchi S., Kobayashi D., Ueyama K., Kuraishi Y., and Hachiga T.: Three-dimensional imaging techniques for micro-vessels using multipoint laser doppler velocimeter. J. Appl. Phys., 106: 054701-1-054701-6, 2009.

    12) Hidaka T., Shima T., Nagira K., Ieki M., Nakamura T., Aono Y., Kuraishi Y., Arai T. and Saito S.: Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. Eur. J. Pain, 13: 22-27, 2009.

    2008

    1) Andoh T., Kishi H., Motoki K., Nakanishi K., Kuraishi Y., and Muraguchi A.: Protective effect of IL-18 on kainate- and IL-1 beta-induced cerebellar ataxia in mice. J. Immunol., 180: 2322-2328, 2008.

    2) Sasaki A., Takasaki I., Andoh T., Shiraki K., Takeshima H., Takahata H., and Kuraishi K.: Nociceptin receptor-deficiency prevents postherpetic pain without effects on acute herpetic pain in mice. Neuroreport., 19: 83-86, 2008.

    3) Nakano T.*, Andoh T., Lee J-B., and Kuraishi Y.: Different dorsal horn neurons responding to histamine and allergic itch stimuli. Neuroreport., 19: 723-726, 2008.

    4) Andoh T., Yageta Y., Konno M., Yamaguchi-Miyamoto T., Takahata H., Nojima H., Nemoto H., and Kuraishi Y.: Evidence for separate involvement of different mu-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids. J. Pharmacol. Sci., 160: 667-670, 2008.

    5) Andoh T., Sugiyama K., Fujita M., Iida Y., Nojima H., Saiki I., and Kuraishi Y.: Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain. Biol. Pharm. Bull., 31: 520-522, 2008.

    6) Fujita M.*, Andoh T., Saiki I., and Kuraishi Y.: Involvement of endothelin and ETA endothelin receptor in mechanical allodynia in mice given orthotopic melanoma inoculation. J. Pharmacol. Sci., 160: 257-263, 2008.

    7) Nakano T.*, Andoh T., Tayama M., Kosaka M., Lee J-B., and Kuraishi Y.: Effects of topical application of tacrolimus on acute itch-associated responses in mice. Biol. Pharm. Bull., 31: 752-754, 2008.

    8) Sasaki A., Nakashima Y., Takasaki I., Andoh T., Shiraki K., and Kuraishi Y.: Morphine inhibits herpetic allodynia through mu-opioid receptors induced in Abeta-fiber neurons. Neuroreport., 19: 975-979, 2008.

    9) Nakano T.*, Andoh T,. Sasaki A., Nojima H., and Kuraishi Y.: Different roles of capsaicin-sensitive and H1 histamine receptor-expressing sensory neurons in itch of mosquito allergy in mice. Acta Derm. Venereol., 88: 449-454, 2008.

    10) Kuraishi Y., Yageta Y., Konno M., Andoh T., Yamaguchi-Miyamoto T., and Nojima H.: Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice. Biol. Pharm. Bull., 31: 2143-2145, 2008.

    11) Sasaki A., Serizawa K., Andoh T., Shiraki K., Takahata H., and Kuraishi Y.: Pharmacological differences between static and dynamic allodynia in mice with herpetic or postherpetic pain. J. Pharmacol. Sci., 108: 266-273, 2008.

    12) Tsujii K.*, Andoh T., Lee J-B., and Kuraishi Y.: Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice. J. Pharmacol. Sci., 108: 385-388, 2008.

    13) 安東嗣修,宮本幸治,宮崎 剛: リピュジュア含有速乾性液状手指消毒剤の抗菌作用および皮膚への影響に関する検討. 医学と薬学,60: 91-97, 2008.

    2007

    1) Andoh T., Nishikawa Y., Miyamoto-Yamaguchi T., Nojima H., Narumiya S., and Kuraishi Y.: Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice. J. Invest. Dermatol., 127: 2042-2047, 2007.

    2) Sasaki A., Nakashima Y., Takasaki I., Andoh T., Shiraki K., and Kuraishi Y.: Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. J. Pharmacol. Sci., 104: 218-224, 2007.

    3) Kuraishi Y., Ohtsuka E., Nakano T., Kawai S., Andoh T., Nojima N., and Kamimura K.: Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice. J. Pharmacol. Sci., 105: 41-47, 2007.

    4) Sasaki A., Mabuchi T., Serizawa K., Takasaki I., Andoh T., Shiraki K., Itoh S., and Kuraishi Y.: Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodyniain mice. Neuroscience.,150: 459-466, 2007.

    2006

    1) Ui H., Andoh T., Lee J.-B., Nojima H., Kuraishi Y.: Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. Eur. J. Pharmacol, 530: 172-178, 2006.

    2) Sato Y., Akao T., He J-X., Nojima H., Kuraishi Y., Morota T., Asano T., Tani T.: Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3. J. Ethnopharmacol., 105: 409-414, 2006.

    3) Sato-Takeda M., Takasaki I., Takeda K., Sasaki A., Andoh T., Nojima H., Shiraki K., Kuraishi Y., Hanaoka K., Tokunaga K., Yabe T.: Major histocompatibility complex haplotype is associated with postherpetic pain in mice. Anesthesiology, 104: 1063-1069, 2006.

    4) Maekawa T., Nojima H., Kuraishi Y., Aisaka K.: The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur. J. Pharmacol, 542: 179-183, 2006.

    5) Takasaki I., Nojima H., Shiraki K., Kuraishi Y.: Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain. Eur. J. Pharmacol, 550: 62-67, 2006.

    6) Imanishi N., Andoh T., Mantani N., Sakai S., Terasawa K., Shimada Y., Satoh M., Katada Y., Ueda K., Ochiai H.: Macrophage-mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus. Am. J. Chin. Med, 34: 57-69, 2006.

    7) Andoh T., Kuraishi Y.: Suppression by bepotastine besilate of substance P-induced itch-associated responses through the inhibition of the leukotriene B4 action in mice. Eur. J. Pharamcol, 547: 59-64, 2006

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