Main research projects

• 1. Clarify the roles of novel molecules-related psychiatric diseases and drug addiction
  We found novel molecules using by cDNA subtraction methods from the nucleus accumbens of psychostimulant-treated mice. We investigate the physiological activities and roles of the novel molecules using behavioral pharmacological, electrophysiological, and molecular biological methods.
• 2. Clarify the mechanisms of nicotine, methamphetamine and THC addiction
  Drug addiction is severe problems over the world. We attempt to clarify the mechanism of establishment of nicotine, methamphetamine and THC to find new prevention and treatment methods.
• 3. Development of a neuropsychiatric disorder model animal and a cell model, and development of curative medicine
  To make a new medicine, the animal models of mental diseases are indispensable. However, it is so difficult to create the neuropsychiatric disorder model because we cannot hear the feeling of an animal. Then, we pursued about the genetic factor and environmental factor of neuropsychiatric disorder, and aims at creation of a model animal, and creation of the curative medicine.
• 4. Pharmaceutical studies
  We propose new systems to supply best pharmaceutical services.
  

We behavioral, biochemical and molecular biological methods for the studies for making the diseases' animal models. We have expected to rescue the patient from psychiatric, neurological diseases and

Publications

• 1. Uno K, Kikuchi Y, Iwata M, Uehara T, Matsuoka T, Sumiyoshi T, Okamoto Y, Jinno H, Takada T, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A: Decreased DNA methylation in the Shati/Nat8I promotor in both patients with schizophrenia and a methamphetamine-induced murine model of schizophrenia-like phenotype. PlosOne. 2016, 11: e0157959.
• 2. Fu K, Lin H, Miyamoto Y, Wu C, Yang J, Uno K, Nitta A: Pseudoginsenoside-F11 inhibits methamphetamine-induced behaviors by regulating dopaminergic and GABAergic neurons in the nucleus accumbens. Psychopharmacology (Berl). 2016, 233: 831-840.
• 3. Sumi K, Uno K, Matsumura S, Miyamoto Y, Furukawa-Hibi Y, Muramatsu S, Nabeshima T, Nitta A: Induction of neuronal axon outgrowth by Shati/Nat8I by energy metabolism in mice cultured neurons. Neuroreport. 2015, 26: 740-746.
• 4. Nakayama C, Oshima T, Kato A, Nitta A: Development of a communication learning program for pharmacists. Jap J Pharm Health Care Sci. 2015, 41: 80-92.
• 5. Miyamoto Y, Ishikawa Y, legaki N, Sumi K, Fu K, Sato K, Furukawa-Hibi Y, Muramatsu S, Nabeshima T, Uno K, Nitta A. Overexpression of Shati/Nat81, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group Ⅱ mGluRs in mice. Int J Neuropsychopharmacol. 2014,17:1283-1294.