Research

Laboratory of Biorecognition Chemistry

Professor Takenori Tomohiro, Ph.D.
Assistant Professor Junya Chiba, Ph.D.

Mission : The major interest of our laboratory at present is the chemical biology of proteins by focusing research activities on the manipulation of protein functions using our unique chemical devices. Our recent results include the development of novel photo-activatable probes for the identification of drug receptor proteins and the solving of their binding-sites. Our technology enabled to convert a variety of ligands, DNAs, peptides and carbohydrates, into useful multi-functional photo-probes in a one-step manner. We also established a high-throughput approach for solving drug binding-sites within proteins.

Projects : (1) Pro-tag installed multifunctional photo-probes for advanced imaging and specific fishing of drug receptor proteins. (2) Tailor-made macromolecular suits for single molecular packaging of proteins. (3) Rational drug discovery by affinity based lead optimization.

Publications

[Chemistry] : Tetrahedron Lett. 57, 1313 (2016); Chem. Commun. 49, 11551 (2013); Chem. Commun. 49, 10242 (2013); J. Am. Chem. Soc. 128, 15092 (2006). [Application] : Bioorg. Med. Chem. Lett. 25, 1675 (2015); Angew. Chem. Int. Ed. 53,13502 (2014); Chem. Commun. 49, 1811 (2013); Bioorg. Med. Chem. Lett. 23, 5605 (2013); Bioconjugate Chem. 22, 315 (2011). [Review] : Heterocycles, 89, 2697 (2014).