Research

Laboratory of Synthetic and Medical Chemistry

Professor Yuji Matsuya, Ph.D.
Associate Professor Kenji Sugimoto, Ph.D.
Assistant Professor Aki Kohyama, Ph.D.

Technological innovations represented by Combinatorial Chemistry, High Throughput Screening (HTS), and Computer Aided Design for Drugs (CADD), have enabled the recent medicines production field to reform in various ways. In particular, Combinatorial Chemistry and HTS have sped up the medicines production research dramatically by increasing the number of compounds which one synthetic organic chemist can synthesize at a time. At the same time, it has enabled the researchers to evaluate the effectiveness of the compounds rapidly. Combinatorial Chemistry has been contributing to the compound library's synthesis with diverse ranges of substituents. However, if there is a case having a certain basic skeleton forms of pharmacophore, which is indispensable to exhibit biological activity, and you need to get diversity from the basic skeletons, it is difficult to get it through Combinatorial Chemistry. Also, to be able to obtain the unknown lead compound, there is no choice but to depend on the precedent synthetic method. Furthermore, even if CADD presumes the presence of a lead compound, if there is no actual compound, CADD is a pie in the sky. Thus, it is still necessary to have orthodox synthetic chemistry to be able to apply the new innovations to the production of medicine. As you can see, the significance of synthetic chemistry is increasing everyday in the drug production field. The problem we are facing today involving synthetic chemistry is not only the synthesis of natural resources with complicated structure as it was done in earlier times, but also basing the synthesis on synthetic technology to create compounds with better functions. That is the goal all prominent synthetic organic chemists are heading towards. Due to this current situation involving the production of medicines and synthetic chemistry, our laboratory sets our goals as developing new reactions to bring a form of innovation to synthetic chemistry, and production of medicines that are effective and safe.

Main Research Projects

  • 1. Development of novel reactions utilizing organo- or metal-catalysts
  • 2. Development of new reactions based on intramolecular silyl migration
  • 3. Design and synthesis of new compounds effecting a central nervous system
  • 4. Synthesis and SAR studies of small organic molecules for development of novel medicines for treatment of lifestyle related diseases
  • 5. Synthesis of macrolide natural compounds having anti-tumor activities