Professor Masahiko Inoue, Ph.D.
Assistant Professor Yuki Ohishi, Ph.D.
Chemical biology is a new area of biosciences, of which basis depends on chemistry. Our research group (Laboratory of Chemical Biology) is aiming at exploitation any common ground between life and molecules and at creation of an artificial life through the investigation of intermolecular interactions.
Creation of artificial DNAs:
We create a new class of DNA-like oligomers made exclusively of nonnatural nucleosides with four types of nonnatural bases attached to a deoxyribose through C-glycoside bond. The artificial DNAs might be applied to a future extracellular genetic system with information storage and amplifiable abilities.
Regulation of protein functions:
A general method was developed for stabilizing α-helices of short peptides with our cross-linking agents. We aim at replacing proteins with the short helical peptides for intracellurar protein-biomolecule interactions in order to resolve unknown biological events at molecular level and to develop next-generation drugs.
Developments of saccharide-recognition molecules:
Various ethynylpyridine-based polymers and oligomers were designed and synthesized as conceptually new host molecules for saccharide recognition. We also apply the host molecules to mediators and catalysts for new reactions of saccharides and to materials of biological and industrial interest.
Faculty of Pharmacy and Pharmaceutical Sciences, University of Toyama
2630 Sugitani, Toyama-shi 930-0194, Phone: 076-434-2281 (main number)
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