• Laboratory of Biopharmaceutics
• Laboratory of Applied Phrmacology
• Laboratory of Biorecognition Chemistry
• Laboratory of Cancer Cell Biology
• Laboratory of Chemical Biology
• Laboratory of Synthetic and
  Medicinal Chemistry
• Laboratory of Molecular Neurobiology
• Laboratory of Gene Regulation
• Laboratory of Molecular Cell Biology
• Laboratory of Medicinal Bioresources
• Laboratory of Synthetic and Biomolecular Organic Chemistry
• Laboratory of Biointerface Chemistry
• Laboratory of Structual Biology
• Laboratory of Phrmaceutical Physiology
• Laboratory of Medical Pharmaceutics
  Laboratory of Community Pharmacy
• Laboratory of Plant Resource Sciences
• Laboratory of Clinical Pharmacology
• Laboratory of Clinical Pharmacokinetics
• Laboratory of Pharmaceutical Therapy
  and Neuropharmacology
• Department of Hospital Pharmacy
• Department of Pharmaceutical Technology
• Division of Pharmacognosy
• Division of Natural Products Chemistry
• Division of Kampo-Pharmaceutics
• Division of Medicinal Pharmacology
• Division of Pathogenic Biochemistry
• Division of Gastrointestinal Pathophysiology
• Division of Neuromedical Science
• Division of Nutritional Biochemistry
• Division of Kampo Diagnostics
• Division of Natural Drug Discovery
• Molecular Genetics Research Laboratory, Life Science Research Center

In order to adapt stressful conditions, cells have developed cellular stress response systems. One of these is endoplasmic reticulum (ER) stress which is defined as accumulation of unfolded proteins. ER stress induces a coordinated cytoprotective program called unfolded protein response (UPR), and is vital to the protein quality control and the proteasome plays a key role in it. If the stress is beyond capacity of the adaptive machinery, cells undergo cell death. We are currently studying the molecular mechanisms underlying cellular responses to ER stress, heat stress, mechanical stress, etc. using recombinant genetic engineering and bioinformatics technologies.

Theme of research :
1. Molecular mechanisms of stress response

Publications

• 1. Tabuchi et al.: Common gene expression patterns responsive to mild temperature hyperthermia in normal human fibroblastic cells. Int J Hyperthermia 29, 38-50 (2013)
• 2. Tabuchi et al.: Genes responsive to low-intensity pulsed ultrasound in MC3T3-E1 preosteoblast cells. Int J Mol Sci 14, 22721-40 (2013)
• 3. Tabuchi et al.: Genes and gene networks involved in sodium fluoride-elicited cell death accompanying endoplasmic reticulum stress in oral epithelial cells. Int J Mol Sci 15,. 8959-78 (2014)