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Department of Cancer Cell Biology, University of Toyama

研究業績  

主要論文リスト
 がん、シグナル伝達薬物代謝酵素


最近の研究業績
原著論文、総説、著書
2017 
Zhou Y. and Sakurai H.:
Emerging and diverse roles of the EphA2 noncanonical pathway in cancer progression. (Review)
Biol. Pharm. Bull., 40: 1616-1624, 2017. [Abstract]
Park C.M., Kawasaki Y., Refaat A., and Sakurai H.:
Two different mechanisms for chemotherapeutic agent-induced inactivation of ErbB2 and ErbB3 via ERK and p38 pathways in breast cancer cells.

Oncol. Lett.,
in press, 2017. [Abstract]
Chen S.G., Leu Y.L., Cheng M.L., Ting S.C., Liu C.C., Wang S.D., Yang C.H., Hung C.Y, Sakurai H., Chen K.H., Ho H.Y.:
Anti-enterovirus 71 activity of Melissa officinalis extract and its biologically active constituent rosmarinic acid.

Sci. Rep.,
7: 12264, 2017. [Open Access]
Chen S.G., Cheng M.L., Chen K.H., Horng J.T., Liu C.C., Wang S.M., Sakurai H., Leu Y.L., Wang S.D.:
Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo.

Sci. Rep.,
7: 935, 2017. [Open Access]
Managit C., Sakurai H., and Saiki I.:
Ethanolic extract of Thevetia Peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways.

Oncol. Lett.,
13: 2791-2798, 2017. [Abstract]
Li P., Zhao Q.L., Jawaid P., Rehman M.U., Sakurai H., and Kondo T.
Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells.

Int. J. Hyperthermia,
177: 766-774, 2017. [Abstract]
Refaat A., Pararasa C., Arif M., Brown J.E.P., Carmichael A., Ali S.S., Sakurai H., and Griffiths H.R.:
Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells.

Free Radic. Res.,
51: 211-221, 2017. [Abstract]
Noujima-Harada M., Takata K., Miyata-Takata T., Sakurai H., Igarashi K., Ito E., Nagakita K., Taniguchi K., Ohnishi N., Omote S., Tabata T., Sato Y., Maeda Y., Tanimoto M., and Yoshino T.
Frequent downregulation of BTB and CNC homology 2 expression in Epstein–Barr virus-positive diffuse large B-cell lymphoma.

Cancer Sci.,
108: 1071-1079,, 2017. [Abstract]
櫻井宏明:
チロシンキナーゼ型受容体の非定型的活性化:がん病態制御の次なる標的.(誌上シンポジウム)
薬学雑誌, 137: 141-144, 2017.
[Open Access]
2016 
Kawasaki K., Sakimura A., Park C.M., Tomaru R., Ozawa T., Zhou Y., Narita K., Kishi H., Muraguchi A., and Sakurai H.:
Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

Sci. Rep.,
6: 31502, 2016. [Open Access]
Kato S., Yokoyama S., Hayakawa Y., Luhui L., Iwakami Y., Sakurai H., and Saiki I.
p38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer.

Cancer Sci.,
107: 1416–1421, 2016. [Abstract]
Li P., Zhao Q.L., Jawaid P., Rehman M.U., Sakurai H., and Kondo T.
Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells.

Cell Stress Chaperones,
21: 873-881, 2016. [Abstract]
Muhammad J.S., Zaidi S.F., Zhou Y., Sakurai H., and Sugiyama T.:
Novel epidermal growth factor receptor pathway mediates release of human β-defensin 3 from Helicobacter pylori-infected gastric epithelial cells.
Pathog. Dis., 74: ftv128, 2016. [Abstract]
2015 
Zhou Y., Yamada N., Tanaka T., Hori T., Yokoyma S., Hayakawa Y., Yano S., Fukuoka J., Koizumi K., Saiki I., and Sakurai H.:
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
Nat. Commun., 6: 7679, 2015. [Open Access]
Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S., Shin M.S., Koizumi K., Yokoyama S., Saiki I., and Sakurai H.:
Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.

Biochem. Biophys. Res. Commun.,
458: 856-861, 2015. [Abstract]
Zaidi S.F., Refaat A., Zhou Y., Muhammad J.S., Shin M.S., Saiki I., Sakurai H., and Sugiyama T.:
Helicobacter pylori induces serine phosphorylation of EGFR via novel TAK1-p38 activation pathway in an HB-EGF-independent manner.

Helicobacter,
20: 381-390, 2015. [Abstract]
Refaat A., Abdelhamed S., Saiki I., and Sakurai H.:
Inhibition of p38 MAPK potentiates the apoptotic effect of berberine/TRAIL combination.
Oncol. Lett.,
10: 1907-1911, 2015. [Abstract]
Toge M., Yokoyama S., Kato S., Sakurai H., Senda K., Doki Y., Hayakawa Y., Yoshimura N., and Saiki I.:
Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.
Int. J. Oncol., 46: 1844-1848, 2015. [Abstract]
Wada A., Ito A., Iitsuka H., Tsuneyama K., Miyazono T., Murakami J., Shibahara N., Sakurai H., Saiki I., Nakayama T., Yoshie O., Koizumi K., and Sugiyama T.:
Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

Oncol. Rep.,
33: 2935-2939, 2015. [Abstract]
Inujima A., Yamada M., Takeno N., Hoshina A., Oe M., Shinohara K., Shibahara N., Sakurai H., Saiki I., and Koizumi K.:
A herbal plant derived compound, 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), increases cross-presentation of antigens to MHC class I molecules in dendritic cells.

Trad. Kampo Med.,
2: 43-49, 2015. [Abstract]
Kee J.Y., Inujima A., Andoh T., Tanaka K., Li F., Kuraishi Y., Sakurai H., Shibahara N., Saiki I., and Koizumi K.:
Inhibitory effect of Moutan cortex aqueous fraction on mast cell-mediated allergic inflammation.
J. Nat. Med.,
69: 209-217, 2015. [Abstract]
Takeno N., Inujima A., Shinohara K., Yamada M., Shibahara N., Sakurai H., Saiki I., and Koizumi K.:
Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in mouse model.
Int. J. Oncol., 47: 2115-2122, 2015. [Abstract]
Tanaka K., Arita M., Sakurai H., Ono N., Tezuka Y.:
Analysis of chemical properties of edible and medicinal ginger by metabolomics approach.

BioMed Res. Int.,
2015: 671058, 2015. [Abstract]
Kimura K., Inoue K., Okubo J., Ueda Y., Kawaguchi K., Sakurai H., Wada I., Morita M., and Imanaka T.:
Endoplasmic reticulum stress response and mutant protein degradation in CHO cells accumulating antithrombin (C95R) in Russell bodies.

Biol. Pharm. Bull.,
38: 1980-4, 2015. [Abstract]
櫻井宏明、古澤之裕、近藤隆:
ストレス応答キナーゼTAK1による細胞応答の制御.(総説)
放射線生物研究, 50: 242-254, 2015.
2014 
Zhou Y., Tanaka T., Sugiyama N., Yokoyama S., Kawasaki Y., Sakuma T., Ishihama Y., Saiki I., and Sakurai H.:
p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
FEBS Lett., 588: 131-137, 2014. [Abstract]
Kaneto N., Yokoyama S., Hayakawa Y., Kato S., Sakurai H., and Saiki I.:
RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer.
Cancer Sci., 105: 788-794, 2014. [Abstract]
Kato S., Hayakawa Y., Sakurai H., Saiki I., and Yokoyama S.:
Mesenchymal-transitioned cancer cells instigate epithelial cancer cells to metastasis through secretion of WNT3 and WNT5B.
Cancer Sci., 105: 281-289, 2014. [Abstract]
Habibie, Yokoyama S., Abdelhamed S., Awale S., Sakurai H., Hayakawa Y., and Saiki I.:
Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis.
Int. J. Oncol., 45: 895-901, 2014. [Abstract]
Kee J.Y., Ito A., Hojo S., Hashimoto I., Tsuneyama K., Tsukada K., Irimura T., Shibahara N., Takasaki I., Inujima A., Nakayama T., Yoshie O., Sakurai H., Saiki I., and Koizumi K.:
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

BMC Cancer,
14: 949, 2014. [Abstract]
2013 
Caballero-Franco C., Choo M.K., Sano Y., Ritprajak P., Shim J.H., Sakurai H., Otsu K., Glimcher L.H., Mizoguchi A., and Park J.M.:
Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.
J. Biol. Chem., 288: 23788-23797, 2013. [Abstract]
櫻井宏明、徳永文稔:
特集「次世代シグナル伝達研究-先駆的基礎解析と臨床・創薬への展開-」.
生化学, 85: 403-404, 2013. [Link]
周越、田中智大、櫻井宏明:
チロシンキナーゼ型受容体のセリン/トレオニンリン酸化制御.
生化学, 85: 462-468, 2013. [Link]
Sato K., Shin M.S., Sakimura A., Zhou Y., Tanaka T., Kawanishi M., Kawasaki Y., Yokoyama S., Koizumi K., Saiki I., and Sakurai H.:
Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation.
Cancer Sci., 104: 1315-1322, 2013. [Abstract]
Li P., Furusawa Y., Wei Z.L., Sakurai H., Tabuchi Y., Zhao Q.L., Saiki I., and Kondo T.:
TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress.
Int. J. Hyperthermia, 29: 688-695, 2013. [Abstract]
Kin R., Kato S., Kaneto N., Sakurai H., Hayakawa Y., Li F., Tanaka K., Saiki I., and Yokoyama S.:
Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in lung cancer cell lines.
Int. J. Oncol., 43: 1901-1906, 2013. [Abstract]
Saiki I., Koizumi K., Goto H., Inujima A., Namiki T., Raimura M., Kogure T., Tatsumi T., Inoue H., Sakai H., Oka H., Fujimoto M., Hikiami H., Sakurai H., Shibahara N., Shimada Y., and Origasa H.:
The long-term effects of a Kampo medicine, Juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination.
Evid. Based Complement. Alternat. Med., 568074, 2013.[Abstract]
Lirdprapamongkol K., Sakurai H., Abdelhamed S., Yokoyama S., Athikomkulchai S., Viriyaroj A., Awale S., Ruchirawat S., Svasti J., and Saiki I.:
Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 down-regulation by inhibiting STAT3 phosphorylation.
Int. J. Oncol., 43: 329-337, 2013. [Abstract]
Lirdprapamongkol K., Sakurai H., Abdelhamed S., Yokoyama S., Maruyama T., Athikomkulchai S., Viriyaroj A., Awale S., Yagita H., Ruchirawat S., Svasti J., and Saiki I.:
A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.
Oncol Rep., 30: 2357-2364, 2013. [Abstract]
Kee J.Y., Ito A., Hojo S., Hashimoto I., Igarashi Y., Tsukada K., Irimura T., Shibahara N., Nakayama T., Yoshie O., Sakurai H., Saiki I., and Koizumi K.:
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating NKT cells in a murine model.
Oncol. Rep., 29, 975-982, 2013. [Abstract]
Kee J.Y., Arita Y., Shinohara K., Ohashi Y., Sakurai H., Saiki I., and Koizumi K.:
Anti-tumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo.
Mol. Clin. Oncol., 1: 35-40, 2013. [Abstract]
Xue R., Han N., Sakurai H., Saiki I., Ye C., Yin J.:
Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas.
Planta Med., 79, 157-162, 2013. [Abstract]
Minato D., Li B., Zhou D., Shigeta Y., Toyooka N., Sakurai H., Sugimoto K., Nemoto H., and Matsuya Y.:
Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1.
Tetrahedron, 69: 8019-8024,, 2013. [Abstract]
Waiwut P., Inoue H., Saiki I., and Sakurai H.:
Gomisin N: a herb-derived compound that enhances death receptor-mediated apoptosis of cancer cells.
Traditional Medicine: New Research, (Ed.) Yoshiharu Motoo. Nova Science Publishers, Inc., New York, pp147-157, 2013.
2012 
Sakurai H.:
Targeting of TAK1 in inflammatory disorders and cancer. (Review)
Trends Pharmacol. Sci., 30: 522-530, 2012. [Abstract]
Shindo S., Sakuma T., Negishi M., Squires J.:
Phosphorylation of serine 212 confers novel activity to human estrogen receptor α.
Steroids, 77: 448-453, 2012. [Abstract]
Chatuphonprasert W., Nemoto N., Sakuma T., and Jarukamjorn K.:
Modulations of cytochrome P450 expression in diabetic mice by berberine.
Chem. Biol. Interact., 196: 23-29, 2012. [Abstract]
Waiwut P., Shin M.S., Yokoyama S., Saiki I., and Sakurai H.:
Gomisin A enhances TNF-α-induced G1 cell cycle arrest via STAT1-mediated phosphorylation of Retinoblastoma protein.
Biol. Pharm. Bull., 35: 1997-2003, 2012. [Abstract]
Furusawa Y., Wei Z.L., Sakurai H., Tabuchi Y., Li P., Zhao Q.L., Nomura T., Saiki I., and Kondo T.:
TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.
Radiat. Res., 177: 766-774, 2012. [Abstract]
Koizumi K., Kato S., Sakurai H., Hashimoto I., Yasumoto K., and Saiki I:
Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer. (Review)
Front. Biosci., 4: 269-276, 2012. [Abstract]
Waiwut P, Inujima A, Inoue H, Saiki I, Sakurai H.:
Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways.
Int. J. Oncol., 40: 203-208, 2012. [Abstract]
Inoue H, Waiwut P, Saiki I, Shimada Y., and Sakurai H.:
Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptor 4 and 5.
Int. J. Oncol., 40: 1058-1065, 2012. [Abstract]
Igarashi Y., Iida T., Fukuda T., Miyanaga S., Sakurai H., Saiki I., and Miyanouchi K.:
Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.
J. Antibiot., 65: 207-209, 2012. [Abstract]
Prangsaengtong O., Senda K., Doki Y., Yeon J., Jo M., Sakurai H., Shibahara N., Saiki I., and Koizumi K.:
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation.
Human Cell, 25: 36-44, 2012. [Abstract]
Suzuki K., Hayashi R., Ichikawa T., Imanishi S., Yamada T., Inomata M., Miwa T., Matsui S., Usui I., Urakaze M., Matsuya U., Ogawa H., Sakurai H., Saiki I., and Tobe K.:
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Oncol. Rep., 27: 1726-1732, 2012. [Abstract]
Ozawa T., Piao X., Kobayashi E., Zhou Y., Sakurai H., Ando T., Jin A., Kishi H., and Muraguchi A.:
A novel rabbit immunospot array assay on a ship allows for the rapid generation of rabbit monoclonal antibodies with high affinity.
PLoS ONE, 7: e52383, 2012. [Abstract]
2011 
Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.:
Distinct roles of transforming growth factor-β-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.
J. Biol. Chem., 286: 21092-21099, 2011. [Abstract]
Waiwut P., Shin M.S., Inujima A., Zhou Y., Koizumi K., Saiki I., and Sakurai H.:
Gomisin N enhances TNF-α-induced apoptosis via inhibition of NF-κB and EGFR survival pathways.
Mol. Cell. Biochem., 350: 169-175, 2011. [Abstract]
Udomsuk L, Jarukamjorn K, Putalun W, Sakuma T, Kawasaki Y, Nemoto N.:
Modified expression of aryl hydrocarbon receptor-related genes by deoxymiroestrol, a phytoestrogen, in mouse hepatocytes in primary culture.
J. Ethnopharmacol., 137: 902-908, 2011. [Abstract]
Prangsaengtong O., Koizumi K., Senda K., Sakurai H., and Saiki I.:
eNOS and Hsp90 interaction directly correlates with the cord formation in human lymphatic endothelial cells.
Lymphat. Res. Biol., 9: 53-59, 2011. [Abstract]
Mizumoto Y., Kyo S., Kiyono T., Takakura M., Nakamura M., Maida Y., Mori N., Bono Y., Sakurai H., and Inoue M.:
Activation of NF-κB is a novel target of KRAS-induced endometrial carcinogenesis.
Clin. Cancer Res., 17: 1341-1350, 2011. [Abstract]
Kondo S, Chatuphonprasert W, Jaruchotikamol A, Sakuma T, Nemoto N.:
Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes.
Toxicology, 280: 18-23, 2011. [Abstract]
Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., and Shimada Y.:
Cinnamaldehyde and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia..
J. Trad. Med., 28: 149-1517, 2011.
Thanaketpaisarn O, Waiwut P, Sakurai H, Saiki I.:
Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.
Int. J. Oncol., 39: 279-285, 2011. [Abstract]
Bhadhprasit W, Sakuma T, Kawasaki Y, Nemoto N.:
Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver.
Drug Metab. Dispos., 39: 490-497, 2011. [Abstract]
Oka H., Goto H., Koizumi K., Nakamura S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki I., and Shimada Y.:
Effect of hachimijiogan against renal dysfunction and involvement of hypoxia inducible factor-1α in the remnant kidney model.
Evid. Based Complement. Alternat. Med., 348686, 2011. [Abstract]
Wolf A., Beuerlein K., Eckart C., Weiser H., Dickkopf B., Müller H., Sakurai H., and Kracht M.:
Identification and functional characterization of a novel phosphorylation sites in TAK1-binding protein (TAB) 1.
PLoS ONE, 6: e29256, 2011. [Abstract]