Department of Cancer Cell Biology, University of Toyama
研究業績
主要論文リスト| 原著論文、総説、著書 |
| 2024 |
| Yasuta Y., Kaminaka R., Nagai S., Mouri S., Ishida K., Tanaka A., Zhou Y., Sakurai H., Yokoyama S.: Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia. Sci. Rep.,14: 1525, 2024. [Opne Acess] |
| Zhou Y., Takahashi J., and Sakurai H.: (Review article) New directions for advanced targeting strategies of EGFR signaling in cancer. Biol. Pharm. Bull., in press. [Abstract] |
| 2023 |
| Ohishi Y., Nishioki K., Miyaoka Y., Serizawa K., Sugawara S., Hayashi K.,
Inoue D., Iwamura M., Yokoyama S., Chiba J, and Inouye M.: A versatile synthetic method for photophysically and chemically stable [5]rotaxane-type fluorescence dyes of various colors by using a cooperative capture strategy. Adv. Opt. Mater., in press, 2023. [Abstract] |
| Ucche S., Yokoyama S., Mojic M., Oki K., Ohshima C., Tsuihiji H., Takasaki
I., Tahara H., and Hayakawa Y.: GSTA4 governs melanoma immune resistance and metastasis. Mol Cancer Res., 21: 76-85, 2023. [Abstract] |
| Zhou Y., Oki R., Tanaka A., Takashima A., Hamada N., Yokoyama S., Yano
S., and Sakurai H.: Cellular stress induces non-canonical activation of the receptor tyrosine kinase EphA2 through the p38-MK2-RSK signaling pathway. J. Biol. Chem., 299: 104699, 2023. [Opne Acess] |
| Koyama A., Shiuchi A., Zhou Y., Tanioka M., Sugimoto K., Sakurai H. and
Matsuya Y.: Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity. Org. Biomol. Chem., 21: 4656-4660, 2023. [Abstract] |
| 2022 |
| Yamagishi N., Takahashi J., Zhou Y., Yokoyama S., Makino T., Shimizu T.,
and Sakurai H.: Non-canonical regulation of EGFR by the air pollutant 9,10-phenanthrenequinone. Biol. Pharm. Bull., 45: 1553-1558, 2022. [Abstract] |
| Takahashi J., Nakamura S., Onuma I., Zhou Y., Yokoyama S., and Sakurai
H.: Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis. Sci. Rep., 12: 11561, 2022. [Abstract] |
| Zhou Y. and Sakurai H.: New trend in ligand-induced EGFR trafficking: A dual-mode clathrin-mediated endocytosis model. (Review) J. Proteomics, 255: 104503, 2022. [Abstract] |
| Yonehara K., Zhou Y., Takahashi J., Yokoyama S., Tomihara K., Noguchi M.,
and Sakurai H.: RSK-mediated non-canonical activation of EphA2 by tamoxifen. Biol. Pharm. Bull., 45: 162-168, 2022 [Abstract] |
| 2021 |
| Yokoyama S., Takahashi A., Kikuchi R., Nishibu S., Lo J., Hejna M., Moon
W.M., Kato S., Zhou Y., Hodi F.S., Song J.S., Sakurai H., Fisher D.E.,
and Hayakawa Y.: SOX10 regulates melanoma immunogenicity through an IRF4-IRF1 axis. Cancer Res., 81: 6131-6141, 2021. [Abstract] |
| Verdaguer M.P., Zhang T., Paulo J., Gygi S., Watkins S., Sakurai H., and
Sorkin A.: Mechanism of p38 MAPK-induced EGFR endocytosis and its crosstalks with ligand-induced pathways. J. Cell Biol., 220: e202102005, 2021. [Abstract] |
| Haryuni R.D., Tanaka T., Takahashi J., Onuma I., Zhou Y., Yokoyama S.,
and Sakurai H.: Temozolomide induces endocytosis of EGFRvIII via p38-mediated non-canonical phosphorylation in glioblastoma cells. Biol. Pharm. Bull., 44: 1681-1687, 2021. [Abstract] |
| Cai B.X., Song L.X., Hu H.J., Han Z.Z., Zhou Y., Wang Z.T., and Yang L.: Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia. Nat. Prod. Res., 35: 5120-5124, 2021. [Abstract] |
| Abdellatef A.A., Zhou Y., Yamada A., Kohyama A., Yokoyama S., Meselhy R.M., Matsuya Y., Sakurai H., and Hayakawa Y.: Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses metastatic potential of breast cancer cells. Biomed. Pharmacother., 140: 111737, 2021. [Abstract] |
| Umeyama L., Kasahara S., Sugawara M., Yokoyama S., Saiki I.,and Hayakawa
Y.: Anti-inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae (FBRA) on mice. Trad. Kampo Med., 8: 60-65, 2021. [Abstract] |
| Umeyama L., Hardianti B., Kasahara S., Dibwe D.F., Awale S., Yokoyama S.,
and Hayakawa Y.: Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice. BMC Complement. Med. Ther., 21, 115, 2021. [Abstract] |
| Song L., Yang F., Wang Z., Yang L., and Zhou Y.: Ginsenoside Rg5 inhibits cancer cell migration by inhibiting the nuclear factor-κB and erythropoietin-producing hepatocellular receptor A2 signaling pathways. Oncol. Lett., 21: 452, 2021. [Abstract] |
| Wang Z., Liang X., Xiong A., Ding L., Li W., Yang L., Wu X., Shi H., Zhou Y., and Wang Z.: Helichrysetin and TNF-α synergistically promote apoptosis by inhibiting overactivation of the NF-κB and EGFR signaling pathways in HeLa and T98G cells. Int. J. Mol. Med., 47: 49, 2021. [Abstract] |
| 櫻井宏明： 1. がんの発生と進展機構、3. シグナル伝達系 新臨床腫瘍学（改訂第6版） 日本臨床腫瘍学会編集、南江堂、pp16-22, 2021. [Link] |
| 横山 悟： I. メラノーマ、4. メラノーマの分子病理学およびゲノミクス、6) メラノーマにおける受容体型チロシンキナーゼ：KIT 皮膚悪性腫瘍（第2版）上 日本臨床第79巻増刊号2、日本臨床社、pp107-111, 2021. [Link] |
| 2020 |
| Yokoyama S., Iwakami Y., Hang Z., Kin R., Zhou Y., Yasuta Y., Takahashi
A., Hayakawa Y., and Sakurai H.: Targeting PSMD14 inhibits melanoma growth through SMAD3 stabilization. Sci. Rep., 10:19214, 2020. [Abstract] |
| Haryuni R.D., Tanaka T., Zhou Y., Yokoyama S., and Sakurai H.: ERK-mediated negative feedback regulation of oncogenic EGFRvIII in glioblastoma cells. Oncol. Lett., 20: 2477-2482, 2020. [Abstract] |
| Xu X., Eshima S., Kato S., Fisher D.E., Sakurai H., Hayakawa Y., and Yokoyama
S.: Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death. Mol. Cancer Ther., 19: 627-636, 2020. [Abstract] |
| Hardianti B., Umeyama L., Li F., Yokoyama S., Hayakawa Y.: Anti‑inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol. Med. Rep., 22: 5385-5391, 2020. [Abstract] |
| Susmitha G.D., Miyazato K., Ogura K., Yokoyama S., Hayakawa Y.: Anti-metastatic effects of baicalein by targeting STAT3 activity in breast cancer cells. Biol. Pharm. Bull., 43: 1899-1905, 2020. [Abstract] |
| Ruan D., Liu W., Shi Y., Tan M., Yang L., Wang Z., Zhou Y., and Wang R.: Protective effects of aqueous extract of Radix Isatidis on lipopolysaccharide-induced sepsis in C57BL/6J mice. J. Med. Food, 23:79-89, 2020. [Abstract] |
| 周越、櫻井宏明： 細胞内から受容体型チロシンキナーゼを活性化する仕組み. 生化学, 92: 420-430, 2020. [Link] |
| 田中智大、周越、櫻井宏明： Phos-tag 解析から見えてきた新しい EGFR 活性化機構. 電気泳動, 64: 45-48, 2020. [Link] |
| 櫻井宏明： 放射線と薬（第Ⅰ部 第5章） アクティブラーニングで学ぶ震災・復興学（庄司美樹、新里泰孝、橋本勝 編著）、六花出版、pp56-66, 2020. [Link] |
| 2019 |
| Haryuni R.D., Watabe S., Yamaguchi A., Fukushi Y., Tanaka T., Kawasaki
Y., Zhou Y., Yokoyama S., and Sakurai H.: Negative feedback regulation of ErbB4 tyrosine kinase activity by ERK-mediated non-canonical phosphorylation. Biochem. Biophys. Res. Commun., 514: 456-461, 2019. [Abstract] |
| Kumrungsee T., Kariya T., Hashimoto K., Koyano T., Yazawa N., Hashimoto
T., Sanada Y., Matsuyama M., Sotomaru Y., Sakurai H., van de Loo F.A.,
and Yanaka N.: The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment. Sci. Rep., 9: 14101, 2019. [Abstract] |
| 2018 |
| Tanaka T., Zhou Y. Ozawa T., Okizono R., Banba A., Yamamura T., Oga E.,
Muraguchi A., and Sakurai H.: Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation. J. Biol. Chem., 293: 2288-2301, 2018. [Abstract] |
| Watanabe K., Yokoyama S., Kaneto N., Hori T., Iwakami Y., Kato S., Hayakawa Y., Sakurai H., Fukuoka J., and Saiki I.: COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL. Oncotarget, 9: 20670-20680, 2018. [Abstract] |
| Tanaka T., Ozawa T., Oga E., Muraguchi A., and Sakurai H.: Cisplatin-induced non-canonical endocytosis of EGFR via p38 phosphorylation of the C-terminal region containing Ser-1015 in non-small cell lung cancer cells. Oncol. Lett., 15: 9251-9256, 2018. [Abstract] |
| Refaat A., Owis M., Abdelhamed S., Saiki I., and Sakurai H.: Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model. Oncol. Lett., 15: 4753-4758, 2018. [Abstract] |
| Park C.M., Kawasaki Y., Refaat A., and Sakurai H.: Mechanisms for DNA-damaging agent-induced inactivation of ErbB2 and ErbB3 via the ERK and p38 pathways. Oncol. Lett., 15: 1758-1762, 2018. [Abstract] |
| Iitsuka H., Koizumi K., Inujima A., Suzaki M., Mizuno Y., Takeshita Y.,
Eto T., Otsuka Y., Shimada R., Liu M., Ikeda K., Nakano M., Suzuki R.,
Maruyama K., Zhou Y., Sakurai H., and Shibahara N.: Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect. Biochem. Biophys. Rep., 15: 1758-1762, 2018. [Abstract] |
| 2017 |
| Zhou Y. and Sakurai H.: (Review article) Emerging and diverse roles of the EphA2 noncanonical pathway in cancer progression. Biol. Pharm. Bull., 40: 1616-1624, 2017. [Abstract] |
| Chen S.G., Leu Y.L., Cheng M.L., Ting S.C., Liu C.C., Wang S.D., Yang C.H.,
Hung C.Y, Sakurai H., Chen K.H., Ho H.Y.: Anti-enterovirus 71 activity of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Sci. Rep., 7: 12264, 2017. [Open Access] |
| Chen S.G., Cheng M.L., Chen K.H., Horng J.T., Liu C.C., Wang S.M., Sakurai
H., Leu Y.L., Wang S.D.: Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Sci. Rep., 7: 935, 2017. [Open Access] |
| Managit C., Sakurai H., and Saiki I.: Ethanolic extract of Thevetia Peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways. Oncol. Lett., 13: 2791-2798, 2017. [Abstract] |
| Li P., Zhao Q.L., Jawaid P., Rehman M.U., Sakurai H., and Kondo T. Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells. Int. J. Hyperthermia, 33: 411-418, 2017. [Abstract] |
| Refaat A., Pararasa C., Arif M., Brown J.E.P., Carmichael A., Ali S.S.,
Sakurai H., and Griffiths H.R.: Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells. Free Radic. Res., 51: 211-221, 2017. [Abstract] |
| Noujima-Harada M., Takata K., Miyata-Takata T., Sakurai H., Igarashi K.,
Ito E., Nagakita K., Taniguchi K., Ohnishi N., Omote S., Tabata T., Sato
Y., Maeda Y., Tanimoto M., and Yoshino T. Frequent downregulation of BTB and CNC homology 2 expression in Epstein–Barr virus-positive diffuse large B-cell lymphoma. Cancer Sci., 108: 1071-1079,, 2017. [Abstract] |
| 櫻井宏明： チロシンキナーゼ型受容体の非定型的活性化：がん病態制御の次なる標的.（誌上シンポジウム） 薬学雑誌, 137: 141-144, 2017. [Open Access] |
| 2016 |
| Kawasaki K., Sakimura A., Park C.M., Tomaru R., Ozawa T., Zhou Y., Narita
K., Kishi H., Muraguchi A., and Sakurai H.: Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain. Sci. Rep., 6: 31502, 2016. [Open Access] |
| Kato S., Yokoyama S., Hayakawa Y., Luhui L., Iwakami Y., Sakurai H., and
Saiki I. p38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer. Cancer Sci., 107: 1416–1421, 2016. [Abstract] |
| Li P., Zhao Q.L., Jawaid P., Rehman M.U., Sakurai H., and Kondo T. Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells. Cell Stress Chaperones, 21: 873-881, 2016. [Abstract] |
| Muhammad J.S., Zaidi S.F., Zhou Y., Sakurai H., and Sugiyama T.: Novel epidermal growth factor receptor pathway mediates release of human β-defensin 3 from Helicobacter pylori-infected gastric epithelial cells. Pathog. Dis., 74: ftv128, 2016. [Abstract] |
| 2015 |
| Zhou Y., Yamada N., Tanaka T., Hori T., Yokoyma S., Hayakawa Y., Yano S.,
Fukuoka J., Koizumi K., Saiki I., and Sakurai H.: Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. Nat. Commun., 6: 7679, 2015. [Open Access] |
| Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S.,
Shin M.S., Koizumi K., Yokoyama S., Saiki I., and Sakurai H.: Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells. Biochem. Biophys. Res. Commun., 458: 856-861, 2015. [Abstract] |
| Zaidi S.F., Refaat A., Zhou Y., Muhammad J.S., Shin M.S., Saiki I., Sakurai
H., and Sugiyama T.: Helicobacter pylori induces serine phosphorylation of EGFR via novel TAK1-p38 activation pathway in an HB-EGF-independent manner. Helicobacter, 20: 381-390, 2015. [Abstract] |
| Refaat A., Abdelhamed S., Saiki I., and Sakurai H.: Inhibition of p38 MAPK potentiates the apoptotic effect of berberine/TRAIL combination. Oncol. Lett., 10: 1907-1911, 2015. [Abstract] |
| Toge M., Yokoyama S., Kato S., Sakurai H., Senda K., Doki Y., Hayakawa
Y., Yoshimura N., and Saiki I.: Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer. Int. J. Oncol., 46: 1844-1848, 2015. [Abstract] |
| Wada A., Ito A., Iitsuka H., Tsuneyama K., Miyazono T., Murakami J., Shibahara
N., Sakurai H., Saiki I., Nakayama T., Yoshie O., Koizumi K., and Sugiyama
T.: Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments. Oncol. Rep., 33: 2935-2939, 2015. [Abstract] |
| Inujima A., Yamada M., Takeno N., Hoshina A., Oe M., Shinohara K., Shibahara
N., Sakurai H., Saiki I., and Koizumi K.: A herbal plant derived compound, 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), increases cross-presentation of antigens to MHC class I molecules in dendritic cells. Trad. Kampo Med., 2: 43-49, 2015. [Abstract] |
| Kee J.Y., Inujima A., Andoh T., Tanaka K., Li F., Kuraishi Y., Sakurai
H., Shibahara N., Saiki I., and Koizumi K.: Inhibitory effect of Moutan cortex aqueous fraction on mast cell-mediated allergic inflammation. J. Nat. Med., 69: 209-217, 2015. [Abstract] |
| Takeno N., Inujima A., Shinohara K., Yamada M., Shibahara N., Sakurai H.,
Saiki I., and Koizumi K.: Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in mouse model. Int. J. Oncol., 47: 2115-2122, 2015. [Abstract] |
| Tanaka K., Arita M., Sakurai H., Ono N., Tezuka Y.: Analysis of chemical properties of edible and medicinal ginger by metabolomics approach. BioMed Res. Int., 2015: 671058, 2015. [Abstract] |
| Kimura K., Inoue K., Okubo J., Ueda Y., Kawaguchi K., Sakurai H., Wada
I., Morita M., and Imanaka T.: Endoplasmic reticulum stress response and mutant protein degradation in CHO cells accumulating antithrombin (C95R) in Russell bodies. Biol. Pharm. Bull., 38: 1980-4, 2015. [Abstract] |
| 櫻井宏明、古澤之裕、近藤隆： ストレス応答キナーゼTAK1による細胞応答の制御．（総説） 放射線生物研究, 50: 242-254, 2015. |
| 2014 |
| Zhou Y., Tanaka T., Sugiyama N., Yokoyama S., Kawasaki Y., Sakuma T., Ishihama
Y., Saiki I., and Sakurai H.: p38-Mediated phosphorylation of Eps15 endocytic adaptor protein. FEBS Lett., 588: 131-137, 2014. [Abstract] |
| Kaneto N., Yokoyama S., Hayakawa Y., Kato S., Sakurai H., and Saiki I.: RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer. Cancer Sci., 105: 788-794, 2014. [Abstract] |
| Kato S., Hayakawa Y., Sakurai H., Saiki I., and Yokoyama S.: Mesenchymal-transitioned cancer cells instigate epithelial cancer cells to metastasis through secretion of WNT3 and WNT5B. Cancer Sci., 105: 281-289, 2014. [Abstract] |
| Habibie, Yokoyama S., Abdelhamed S., Awale S., Sakurai H., Hayakawa Y.,
and Saiki I.: Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. Int. J. Oncol., 45: 895-901, 2014. [Abstract] |
| Kee J.Y., Ito A., Hojo S., Hashimoto I., Tsuneyama K., Tsukada K., Irimura
T., Shibahara N., Takasaki I., Inujima A., Nakayama T., Yoshie O., Sakurai
H., Saiki I., and Koizumi K.: CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages. BMC Cancer, 14: 949, 2014. [Abstract] |
| 2013 |
| Caballero-Franco C., Choo M.K., Sano Y., Ritprajak P., Shim J.H., Sakurai H., Otsu K., Glimcher L.H., Mizoguchi A., and Park J.M.: Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis. J. Biol. Chem., 288: 23788-23797, 2013. [Abstract] |
| 櫻井宏明、徳永文稔： 特集「次世代シグナル伝達研究－先駆的基礎解析と臨床・創薬への展開－」. 生化学, 85: 403-404, 2013. [Link] |
| 周越、田中智大、櫻井宏明： チロシンキナーゼ型受容体のセリン／トレオニンリン酸化制御. 生化学, 85: 462-468, 2013. [Link] |
| Sato K., Shin M.S., Sakimura A., Zhou Y., Tanaka T., Kawanishi M., Kawasaki
Y., Yokoyama S., Koizumi K., Saiki I., and Sakurai H.: Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation. Cancer Sci., 104: 1315-1322, 2013. [Abstract] |
| Li P., Furusawa Y., Wei Z.L., Sakurai H., Tabuchi Y., Zhao Q.L., Saiki
I., and Kondo T.: TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress. Int. J. Hyperthermia, 29: 688-695, 2013. [Abstract] |
| Kin R., Kato S., Kaneto N., Sakurai H., Hayakawa Y., Li F., Tanaka K.,
Saiki I., and Yokoyama S.: Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in lung cancer cell lines. Int. J. Oncol., 43: 1901-1906, 2013. [Abstract] |
| Saiki I., Koizumi K., Goto H., Inujima A., Namiki T., Raimura M., Kogure
T., Tatsumi T., Inoue H., Sakai H., Oka H., Fujimoto M., Hikiami H., Sakurai
H., Shibahara N., Shimada Y., and Origasa H.: The long-term effects of a Kampo medicine, Juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination. Evid. Based Complement. Alternat. Med., 568074, 2013.[Abstract] |
| Lirdprapamongkol K., Sakurai H., Abdelhamed S., Yokoyama S., Athikomkulchai
S., Viriyaroj A., Awale S., Ruchirawat S., Svasti J., and Saiki I.: Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 down-regulation by inhibiting STAT3 phosphorylation. Int. J. Oncol., 43: 329-337, 2013. [Abstract] |
| Lirdprapamongkol K., Sakurai H., Abdelhamed S., Yokoyama S., Maruyama T.,
Athikomkulchai S., Viriyaroj A., Awale S., Yagita H., Ruchirawat S., Svasti
J., and Saiki I.: A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep., 30: 2357-2364, 2013. [Abstract] |
| Kee J.Y., Ito A., Hojo S., Hashimoto I., Igarashi Y., Tsukada K., Irimura T., Shibahara N., Nakayama T., Yoshie O., Sakurai H., Saiki I., and Koizumi K.: Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating NKT cells in a murine model. Oncol. Rep., 29, 975-982, 2013. [Abstract] |
| Kee J.Y., Arita Y., Shinohara K., Ohashi Y., Sakurai H., Saiki I., and
Koizumi K.: Anti-tumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo. Mol. Clin. Oncol., 1: 35-40, 2013. [Abstract] |
| Xue R., Han N., Sakurai H., Saiki I., Ye C., Yin J.: Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas. Planta Med., 79, 157-162, 2013. [Abstract] |
| Minato D., Li B., Zhou D., Shigeta Y., Toyooka N., Sakurai H., Sugimoto
K., Nemoto H., and Matsuya Y.: Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1. Tetrahedron, 69: 8019-8024,, 2013. [Abstract] |
| Waiwut P., Inoue H., Saiki I., and Sakurai H.: Gomisin N: a herb-derived compound that enhances death receptor-mediated apoptosis of cancer cells. Traditional Medicine: New Research, (Ed.) Yoshiharu Motoo. Nova Science Publishers, Inc., New York, pp147-157, 2013. |
| 2012 |
| Sakurai H.: Targeting of TAK1 in inflammatory disorders and cancer. (Review) Trends Pharmacol. Sci., 30: 522-530, 2012. [Abstract] |
| Waiwut P., Shin M.S., Yokoyama S., Saiki I., and Sakurai H.: Gomisin A enhances TNF-α-induced G1 cell cycle arrest via STAT1-mediated phosphorylation of Retinoblastoma protein. Biol. Pharm. Bull., 35: 1997-2003, 2012. [Abstract] |
| Furusawa Y., Wei Z.L., Sakurai H., Tabuchi Y., Li P., Zhao Q.L., Nomura
T., Saiki I., and Kondo T.: TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations. Radiat. Res., 177: 766-774, 2012. [Abstract] |
| Koizumi K., Kato S., Sakurai H., Hashimoto I., Yasumoto K., and Saiki I: Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer. (Review) Front. Biosci., 4: 269-276, 2012. [Abstract] |
| Waiwut P, Inujima A, Inoue H, Saiki I,
Sakurai H.: Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways. Int. J. Oncol., 40: 203-208, 2012. [Abstract] |
| Inoue H, Waiwut P, Saiki I, Shimada Y., and Sakurai H.: Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptor 4 and 5. Int. J. Oncol., 40: 1058-1065, 2012. [Abstract] |
| Igarashi Y., Iida T., Fukuda T., Miyanaga S., Sakurai H., Saiki I., and
Miyanouchi K.: Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp. J. Antibiot., 65: 207-209, 2012. [Abstract] |
| Prangsaengtong O., Senda K., Doki Y., Yeon J., Jo M., Sakurai H., Shibahara
N., Saiki I., and Koizumi K.: Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation. Human Cell, 25: 36-44, 2012. [Abstract] |
| Suzuki K., Hayashi R., Ichikawa T., Imanishi S., Yamada T., Inomata M.,
Miwa T., Matsui S., Usui I., Urakaze M., Matsuya U., Ogawa H., Sakurai
H., Saiki I., and Tobe K.: SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncol. Rep., 27: 1726-1732, 2012. [Abstract] |
| Ozawa T., Piao X., Kobayashi E., Zhou Y., Sakurai H., Ando T., Jin A.,
Kishi H., and Muraguchi A.: A novel rabbit immunospot array assay on a ship allows for the rapid generation of rabbit monoclonal antibodies with high affinity. PLoS ONE, 7: e52383, 2012. [Abstract] |
| 2011 |
| Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi
Y., Saiki I., and Sakurai H.: Distinct roles of transforming growth factor-β-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9. J. Biol. Chem., 286: 21092-21099, 2011. [Abstract] |
| Waiwut P., Shin M.S., Inujima A., Zhou Y., Koizumi K., Saiki I., and Sakurai
H.: Gomisin N enhances TNF-α-induced apoptosis via inhibition of NF-κB and EGFR survival pathways. Mol. Cell. Biochem., 350: 169-175, 2011. [Abstract] |
| Prangsaengtong O., Koizumi K., Senda K.,
Sakurai H., and Saiki I.: eNOS and Hsp90 interaction directly correlates with the cord formation in human lymphatic endothelial cells. Lymphat. Res. Biol., 9: 53-59, 2011. [Abstract] |
| Mizumoto Y., Kyo S., Kiyono T., Takakura
M., Nakamura M., Maida Y., Mori N., Bono Y., Sakurai H., and Inoue
M.: Activation of NF-κB is a novel target of KRAS-induced endometrial carcinogenesis. Clin. Cancer Res., 17: 1341-1350, 2011. [Abstract] |
| Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., and Shimada Y.: Cinnamaldehyde and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia.. J. Trad. Med., 28: 149-1517, 2011. |
| Thanaketpaisarn O, Waiwut P, Sakurai H,
Saiki I.: Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways. Int. J. Oncol., 39: 279-285, 2011. [Abstract] |
| Oka H., Goto H., Koizumi K., Nakamura
S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki
I., and Shimada Y.: Effect of hachimijiogan against renal dysfunction and involvement of hypoxia inducible factor-1α in the remnant kidney model. Evid. Based Complement. Alternat. Med., 348686, 2011. [Abstract] |
| Wolf A., Beuerlein K., Eckart C., Weiser H., Dickkopf B., Müller H., Sakurai H., and Kracht M.: Identification and functional characterization of a novel phosphorylation sites in TAK1-binding protein (TAB) 1. PLoS ONE, 6: e29256, 2011. [Abstract] |