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Department of Cancer Cell Biology, University of Toyama

研究業績

主要論文リスト
がん、シグナル伝達
Zhou Y. and Sakurai H.:
Emerging and diverse roles of the EphA2 noncanonical pathway in cancer progression. (Review)
Biol. Pharm. Bull., 40: 1616-1624, 2017. [Abstract]
Kawasaki K., Sakimura A., Park C.M., Tomaru R., Ozawa T., Zhou Y., Narita K., Kishi H., Muraguchi A., and Sakurai H.:
Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

Sci. Rep.,
6: 31502, 2016. [Open Access]
Zhou Y., Yamada N., Tanaka T., Hori T., Yano S., Hayakawa Y., Yokoyma S., Fukuoka J., Koizumi K., Saiki I., and Sakurai H.:
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
Nat. Commun., 6: 7679, 2015. [Open Access]
Caballero-Franco C., Choo M.K., Sano Y., Ritprajak P., Shim J.H., Sakurai H., Otsu K., Glimcher L.H., Mizoguchi A., and Park J.M.:
Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.
J. Biol. Chem., 288: 23788-23797, 2013. [Abstract]
周越、田中智大、櫻井宏明:
チロシンキナーゼ型受容体のセリン/トレオニンリン酸化制御.
生化学, 85: 462-468, 2013.
Sakurai H.:
Targeting of TAK1 in inflammatory disorders and cancer.
Trends Pharmacol. Sci., 30: 522-530, 2012. [Abstract]
Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.:
Distinct roles of transforming growth factor-β-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.
J. Biol. Chem., 286: 21092-20199, 2011. [Abstract]
Mizumoto Y., Kyo S., Kiyono T., Takakura M., Nakamura M., Maida Y., Mori N., Bono Y., Sakurai H., and Inoue M.:
Activation of NF-κB is a novel target of KRAS-induced endometrial carcinogenesis.
Clin. Cancer Res., 17: 1341-1350, 2011. [Abstract]
Suzuki S., Zhou Y., Refaat A., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.:
Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways.
J. Biol. Chem., 285: 4441-4446, 2010. [Abstract]
Sayama K., Yamamoto M., Shirakata Y., Hanakawa Y., Hirakawa S., Dai X., Tohyama M., Tokumaru S., Shin M.S., Sakurai H., Akira S., and Hashimoto K.:
E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.
J. Biol. Chem., 285: 30042-30049, 2010. [Abstract]
櫻井宏明、小泉桂一、済木育夫:
「がん転移 臨床と基礎の羅針盤」、基礎医学編: 2. TNF-αは転移になぜ必要か
細胞工学別冊 (丸義朗監修), 学研メディカル秀潤社, pp139-143, 2010.
Nishimura M., Shin M.S., Singhirunnusorn P., Suzuki S., Kawanishi M., Koizumi K., Saiki I., and Sakurai H.:
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-κB-independent survival pathways in tumor necrosis factor alpha signaling.
Mol. Cell. Biol., 29: 5529-5539, 2009. [Abstract]
Yamazaki K., Gohda J., Kanayama A., Miyamoto Y., Sakurai H., Yamamoto M., Akira S., Hayashi H., Su B., and Inoue J.:
Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling.
Sci. Signal., 2: ra66, 2009. [Abstract]
Koizumi K., Saitoh, Y., Minami T., Tsuneyama K., Miyahara T., Nakayama T., Sakurai H., Takano Y., Nishimura M., Imai T., Yoshie O., and Saiki I.:
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.
J. Immunol., 183: 7825-7831, 2009. [Abstract]
Ueno Y., Sakurai H., Tsunoda S., Matsuo M., Choo M.K., Koizumi K., and Saiki I.:
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells.
Int. J. Cancer, 123: 340-347, 2008. [Abstract]
Singhirunnusorn P., Ueno Y., Matsuo M., Suzuki S., Saiki I., and Sakurai H.:
Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-α through the TAK1-p38 pathway.

J. Biol. Chem., 282: 12698.12706, 2007. [Abstract]
Suzuki S., Singhirunnusorn P., Mori A., Yamaoka S., Kitajima I., Saiki I., and Sakurai H.:
Constitutive activation of TAK1 by HTLV-1 Tax-dependent overexpression of TAB2 induces activation of JNK-ATF2, but not IKK-NF-κB.

J. Biol. Chem., 282: 25177-25181, 2007. [Abstract]
Shambharkar P.B., Blonska M., Pappu B.P., You Y., Sakurai H., Darnay B., and Lin X.:
Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways.

EMBO J., 26: 1794-1805, 2007. [Abstract]
Hojo S., Koizumi K., Tsuneyama K., Arita Y., Cui Z., Shinohara K., Minami T., Hashimoto I., Nakayama T., Sakurai H., Takano Y., Yoshie O., Tsukada K., and Saiki I.:
High level expression of chemokine CXCL16 by tumor cells correlated with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.

Cancer Res., 67: 4725-4731, 2007. [Abstract]
Choo M.K., Sakurai H., Koizumi K., and Saiki I.:
TAK1-mediated stress signaling pathways are essential for TNF-α-promoted pulmonary metastasis of murine colon cancer cells.
Int. J. Cancer, 118: 2758-2764, 2006. [Abstract]
Yasumoto K., Koizumi K., Kawashima A., Saitoh Y., Arita Y., Shinohara K. Minami T., Nakayama T., Sakurai H., Takahashi Y., Yoshie O., and Saiki I.:
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.

Cancer Res., 66: 2181-2187, 2006. [Abstract]
Thiefes A., Wolf A., Grassl G.A., Doerrie A., Matsumoto K., Autenrieth I., Bohn E., Sakurai H., Niedenthal R., Resch K., and Kracht M.:
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
EMBO Rep.
, 7: 838-844, 2006. [Abstract]
Yamamoto M., Sato S., Saitoh T., Sakurai H., Uematsu S., Kawai T., Ishii K.J., Takeuchi O., and Akira S.:
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
J. Immunol., 177: 7520-7524, 2006. [Abstract]
Yamamoto M., Okamoto Y., Takeda T., Sato S., Sanjo H., Uematsu S., Saitoh T., Yamamoto N., Sakurai H., Ishii K.J., Yamaoka S., Kawai T., Matsuura Y., Takeuchi O., and Akira S.:
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nat. Immunol., 7: 962-970, 2006. [Abstract]
Choo M.K., Kawasaki N., Singhirunnusorn P., Koizumi K., Sato S., Akira S., Saiki I., and Sakurai H.:
Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Mol. Cancer Ther., 5: 2970-2976, 2006. [Abstract]
Singhirunnusorn P, Suzuki S., Kawasaki N., Saiki I., and Sakurai H.:
Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-β-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.
J. Biol. Chem., 280: 7359-7368, 2005. [Abstract]
Shinohara H., Yasuda T., Aiba Y., Sanjo H., Hamadate M., Watarai H., Sakurai H., and Kurosaki T.:
PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
J. Exp. Med., 202: 1423-1431, 2005. [Abstract]
Blonska M., Shambharkar P.B., Kobayashi M., Zhang D., Sakurai H., Su B., and Lin X.:
TAK1 is recruited to the tumor necrosis factor-α (TNF-α) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-κB activation.
J. Biol. Chem., 280: 43056-43063, 2005. [Abstract]
Matsuo M., Sakurai H. and Saiki I.:
ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model.
Mol. Cancer Ther.,
2: 557-561, 2003. [Abstract]
Sakurai H., Suzuki S., Kawasaki N., Nakano H., Okazaki T., Chino A., Doi T. and Saiki I.:
Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is medeated through the TRAF2, TRAF5 and TAK1 signaling pathway.
J. Biol. Chem.,
278, 36916-36923, 2003. [Abstract]
Fujita F., Delhase M., Taniguchi Y., Kato T., Narita Y., Furuya A., Ogawa T., Sakurai H., Joh T., Itoh M., Karin M. and Nakanishi M.:
Identification of NAP1: a regulatory subunit of IκB kinase-related kinases that potentiates NF-κB signaling.
Mol. Cell. Biol. , 23, 7780-7793, 2003. [Abstract]
Sizemore N., Lerner N., Dombrowski N., Sakurai H. and Stark G.R.:
Distinct Roles of the IκB kinase α and β subunits in liberating nuclear factor kB (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB.

J. Biol. Chem., 277: 3863-3869, 2002. [Abstract]
Mizukami J., Takaesu G., Akatsuka H., Sakurai H. Ninomiya-Tsuji J., Matsumoto K.and Sakurai N.:
Receptor activator of NF-κB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase through a signaling complex containing TAK1, TAB2, and TRAF6.
Mol. Cell. Biol., 22: 992-1000, 2002. [Abstract]
Yang J., Fan G., Wadzinski B.E., Sakurai H., and Richmond A.:
Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
J. Biol. Chem., 276: 1423-1431, 2001. [Abstract]
Sakurai H., Chiba H., Miyoshi H., Sugita T., and Toriumi W.
IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain.
J. Biol. Chem., 274: 30353-30356, 1999. [Abstract]
Sakurai H., Miyoshi H., Toriumi W., and Sugita T.:
Functional interactions of transforming growth factor β-activated kinase 1 with IκB kinases to stimulate NF-κB activation.
J. Biol. Chem., 274: 10641-10648, 1999. [Abstract]