Lipopolysaccharide-induced functional alteration of P-glycoprotein in the ex vivo rat inner blood–retinal barrier
Daikohara K, Akanuma S, Kubo Y, Hosoya K.
Int J Mol Sci. 2022; 23:15504

Newly-established in vitro inner BRB spheroids to elucidate retinal Ang2-linked substance transfer
Yamamoto Y, Akanuma S, Kon H, Endo H, Kubo Y, Hosoya K.
J Control Release. 2022; 351:8-21

Functional characteristics of 3'-azido-3'-deoxythymidine transport at the blood-testis barrierr
Ito T, Kubo Y, Akanuma S, Hosoya K.
Int J Pharm. 2022; 625:122044

Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF
Jomura R, Akanuma S, Kubo Y, Tachikawa M, Hosoya K.
Fluids Barriers CNS. 2022; 19(1):42

Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier
Akanuma S, Han M, Murayama Y, Kubo Y, Hosoya K.
Pharm Res. 2022; 39:223-237

Freshly isolated retinal capillaries to determine efflux transporter function at the inner BRB
Tajima K, Akanuma S, Ohishi Y, Yoshida Y, Bauer B, Kubo Y, Inouye M, Hosoya K.
J Control Release. 2022; 343:434-442

Involvement of TauT/SLC6A6 in Taurine Transport at the Blood-Testis Barrier
Kubo Y, Ishizuka S, Ito T, Yoneyama D, Akanuma S, Hosoya K.
Metabolites. 2022; 12(1):66

Divergent synthesis of decahydroquinoline-type poison-frog alkaloids
Takashima K, Okada T, Kato A, Yamasaki Y, Sugouchi T, Akanuma S, Kubo Y, Hosoya K, Morita H, Ito T, Kodama T, Tanabe G, Toyooka N.
ChemistrySelect. 2022; 7(5):e202104533

SLC6A and SLC16A family of transporters: Contribution to transport of creatine and creatine precursors in creatine biosynthesis and distribution
Jomura R, Akanuma S, Tachikawa M, Hosoya K.
Biochim Biophys Acta Biomembr. 2022; 1864: 183840

Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent- cis-195A and cis-211A
Okada T, Wu N, Takashima K, Ishimura J, Morita H, Ito T, Kodama T, Yamazaki Y, Akanuma S, Kubo Y, Hosoya K, Tsuneki H, Wada T, Sasaoka T, Shimizu T, Sakai H, Dwoskin LP, Hussaini SR, Saporito RA, Toyooka N.
Molecules. 2021; 26(24):7529

Comprehensive Evidence of Carrier-Mediated Distribution of Amantadine to the Retina across the Blood-Retinal Barrier in Rats
Shinozaki Y, Akanuma S, Mori Y, Kubo Y, Hosoya K.
Pharmaceutics. 2021; 13:1339

Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes
Jomura R, Tanno Y, Akanuma S, Tachikawa M, Kubo Y, Hosoya K.
Am J Physiol Gastrointest Livder Physiol. 2021; 321:G113-G122

Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model
Nakamura G, Ozeki K, Takesue H, Tabo M, Hosoya K.
Biol Pharm Bull. 2021; 44:389-395

Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier
Jomura R, Akanuma S, Bauer B, Yoshida Y, Kubo Y, Hosoya K.
Pharm Res. 2021; 38:113-125

Role of the Blood-Retinal Barrier Transporters: Antiaging in Retina
Hosoya K, Akanuma S, Kubo Y.
Yakugaku Zasshi. 2021; 141(12): 1319-1325

Inflammation-induced attenuation of prostaglandin D2 elimination across rat blood-brain barrier: involvement of the downregulation of organic anion transporter 3 and multidrug resistance-associated protein 4.
Akanuma S, Hashimoto K, Yoshida Y, Kubo Y, Hosoya K.
Biol Pharm Bull. 2020; 43:1669-1677

Involvement of sodium-coupled neutral amino acid transporters (system A) in L-proline transport in the rat retinal pericytes.
Zakoji N, Tajima K, Yoneyama D, Akanuma S, Kubo Y, Hosoya K.
Drug Metab Pharmacokinet. 2020; 35:410-416

Uptake study in lysosome-enriched fraction: Critical involvement of lysosomal trapping in quinacrine uptake but not fluorescence-labeled verapamil transport at blood-retinal barrier.
Kubo Y, Yamada M, Konakawa S, Akanuma S, Hosoya K.
Pharmaceutics. 2020; 12:E747

Monocarboxylate Transporter 12 as a Guanidinoacetate Efflux Transporter in Renal Proximal Tubular Epithelial Cells.
Jomura R, Tanno Y, Akanuma S, Kubo Y, Tachikawa M, Hosoya K.
Biochim Biophys Acta Biomembr. 2020; 8:183434

Characteristics of Hemichannel-Mediated Substrate Transport in Human Retinal Pigment Epithelial Cells under Deprivation of Extracellular Ca2+.
Maruyama S, Akanuma S, Kubo Y, Hosoya K.
Biol Pharm Bull. 2020; 43(8):1241-1247.

Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets.
Yokoyama R, Kimura G, Huwyler J, Hosoya K, Puchkov M.
Pharmaceutics. 2020; 12(6):495.

Predicting Method for the Human Plasma Concentration-Time Profile of a Monoclonal Antibody from the Half-life of Non-human Primates.
Nakamura G, Ozeki K, Nagayasu M, Nambu T, Nemoto T, Hosoya K.
Biol Pharm Bull. 2020; 43(3):823-830.

Determination of Intrinsic Creatine Transporter (Slc6a8) Activity and Creatine Transport Function of Leukocytes in Rats.
Taii A, Tachikawa M, Ohta Y, Hosoya K, Terasaki T.
Biol Pharm Bull. 2020; 43(3):474-479.

Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction.
Inagaki M, Nishimura T, Nakanishi T, Shimada H, Noguchi S, Akanuma S, Tachikawa M, Hosoya K, Tamai I, Nakashima E, Tomi M.
iScience. 2020; 23(5):101098.

Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells.
Tachikawa M, Murakami K, Akaogi R, Akanuma SI, Terasaki T, Hosoya KI.
Neurochem Int. 2020; 132:104600.

Developmental changes in transporter and receptor protein expression levels at the rat blood-brain barrier based on quantitative targeted absolute proteomics.
Omori K, Tachikawa M, Hirose S, Taii A, Akanuma SI, Hosoya KI, Terasaki T.
Drug Metab Pharmacokinet. 2020; 35(1):117-123.

Membrane transporters and their regulatory mechanisms at the brain and retinal barriers to establish therapies for refractory central nervous system diseases.
Akanuma S.
YAKUGAKU ZASSHI. accepted for publication

Foreword.
Ishida T, Kawakami S, Hosoya K.
Biol Pharm Bull. 2020; 43(4):575.

Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier.
Soldner ELB, Hartz AMS, Akanuma SI, Pekcec A, Doods H, Kryscio RJ, Hosoya KI, Bauer B.
FASEB J. 2019 Dec;33(12):13966-13981

Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier.
Kubo Y, Miki S, Akanuma SI, Hosoya KI.
Drug Metab Pharmacokinet. 2019 Dec;34(6):380-386.

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro.
Salomon JJ, Gausterer JC, Selo MA, Hosoya KI, Huwer H, Schneider-Daum N, Lehr CM, Ehrhardt C.
Pharmaceutics. 2019 Aug 7;11(8). pii: E396.

Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules.
Akanuma SI, Kida R, Tsuchiyama A, Tachikawa M, Kubo Y, Hosoya KI.
Drug Metab Pharmacokinet. 2019 Aug;34(4):239-246.

蛍光標識体を用いた血液網膜関門輸送機能の解明.
久保　義行.
ファルマシア．2019; 55(12): 1145-1149

In vivo analysis to study transport across the blood-retinal barrier.
Kubo Y, Akanuma S, Hosoya K.
In Blood-brain barrier (Barichello T Editor; Springer Protocols, Humana Press). 2019; p. 249-265

Techniques for evaluating efflux transport of radiolabeled drugs and compounds from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier.
Akanuma S, Kubo Y, Hosoya K.
In Blood-brain barrier (Barichello T Editor; Springer Protocols, Humana Press). 2019; p. 231-248

Multiple Cellular Transport and Binding Processes of Unesterified Docosahexaenoic Acid in Outer Blood-Retinal Barrier Retinal Pigment Epithelial Cells.
Tachikawa M, Akanuma SI, Imai T, Okayasu S, Tomohiro T, Hatanaka Y, Hosoya KI.
BBiol Pharm Bull. 2018;41(9):1384-1392.

Impact of Nicotine Transport across the Blood-Brain Barrier: Carrier-Mediated Transport of Nicotine and Interaction with Central Nervous System Drugs.
Tega Y, Yamazaki Y, Akanuma SI, Kubo Y, Hosoya KI.
Biol Pharm Bull. 2018;41(9):1330-1336.

Investigation of receptor-mediated cyanocobalamin (vitamin B12) transport across the inner blood-retinal barrier using fluorescence-labeled cyanocobalamin.
Kinoshita Y, Nogami K, Jomura R, Akanuma SI, Abe H, Inouye M, Kubo Y, Hosoya KI.
Mol Pharm. 2018 Aug 6;15(8):3583-3594.

Recent advances in drug and nutrient transport across the blood-retinal barrier.
Kubo Y, Akanuma SI, Hosoya KI.
Expert Opin Drug Metab Toxicol. 2018 May;14(5):513-531.

Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin.
Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI.
Mol Pharm. 2018 Jun 4;15(6):2327-2337.

Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier.
Kubo Y, Nakazawa A, Akanuma SI, Hosoya KI.
Pharm Res. 2018 Mar 12;35(5):93.

Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels.
Tachikawa M, Toki H, Watanabe M, Tomi M, Hosoya KI, Terasaki T.
Anat Sci Int. 2018 Mar 8.

Assembly of Taurine Transporter (Slc6a6) with Na+-H+ Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity.
Tachikawa M, Yokoyama R, Akanuma SI, Hosoya KI.
Biol Pharm Bull. 2018;41(3):338-341.

Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins.
Akanuma SI, Higashi H, Maruyama S, Murakami K, Tachikawa M, Kubo Y, Hosoya KI.
Exp Eye Res. 2018 Mar;168:128-137.

Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain.
Akanuma SI, Yamazaki Y, Kubo Y, Hosoya KI.
Fluids Barriers CNS. 2018 Jan 8;15(1):1.

Developmental changes of l-arginine transport at the blood-brain barrier in rats.
Tachikawa M, Hirose S, Akanuma SI, Matsuyama R, Hosoya KI.
Microvasc Res. 2018 May;117:16-21.

Cell-Type-Specific Spatiotemporal Expression of Creatine Biosynthetic Enzyme S-adenosylmethionine:guanidinoacetate N-methyltransferase in Developing Mouse Brain.
Tachikawa M, Watanabe M, Fukaya M, Sakai K, Terasaki T, Hosoya KI.
Neurochem Res. 2018 Feb;43(2):500-510.

Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.
Tachikawa M, Yashiki A, Akanuma SI, Matsukawa H, Ide S, Minami M, Hosoya KI.
Neurochem Int. 2018 Feb;113:1-7.

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.
Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma SI, Hosoya KI, Urtti A, Terasaki T, Tachikawa M.
Mol Pharm. 2017 Nov 6;14(11):3729-3738.

Involvement of Carrier-Mediated Transport at the Blood-Cerebrospinal Fluid Barrier in Spermine Clearance from Rat Brain.
Akanuma SI, Shimada H, Kubo Y, Hosoya KI.
Biol Pharm Bull. 2017;40(9):1599-1603.

Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants.
Kubo Y, Akanuma SI, Hosoya KI.
Biol Pharm Bull. 2017;40(8):1139-1145.

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts.
Inagaki M, Nishimura T, Akanuma SI, Nakanishi T, Tachikawa M, Tamai I, Hosoya KI, Nakashima E, Tomi M.
Placenta. 2017 May;53:76-82.

Retina-to-Blood Transport of 1-Methyl-4-Phenylpyridinium Involves Carrier-Mediated Process at the Blood-Retinal Barrier.
Kubo Y, Yamamoto M, Matsunaga K, Usui T, Akanuma SI, Hosoya KI.
J Pharm Sci. 2017 Sep;106(9):2583-2591.

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.
Ehrhardt C, Bäckman P, Couet W, Edwards C, Forbes B, Fridén M, Gumbleton M, Hosoya KI, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R.
J Pharm Sci. 2017 Sep;106(9):2234-2244.

Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.
Kubo Y, Yahata S, Miki S, Akanuma SI, Hosoya KI.
Drug Metab Pharmacokinet. 2017 Feb;32(1):92-99.

Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).
Usui T, Nakazawa A, Okura T, Deguchi Y, Akanuma SI, Kubo Y, Hosoya KI.
J Neurochem. 2016 Aug 8.

Lysosomal Trapping Is Present in Retinal Capillary Endothelial Cells: Insight into Its Influence on Cationic Drug Transport at the Inner Blood-Retinal Barrier.
Kubo Y, Seko N, Usui T, Akanuma S, Hosoya K.
Biol Pharm Bull. 2016;39(8):1319-24.

Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells.
Tega Y, Yuzurihara C, Kubo Y, Akanuma S, Ehrhardt C, Hosoya K.
Drug Metab Pharmacokinet. 2016 Feb;31(1):99-101.

Functional Characterization of Carrier-Mediated Transport of Pravastatin across the Blood-Retinal Barrier in Rats.
Fujii S, Setoguchi C, Kawazu K, Hosoya K.
Drug Metab Dispos. 2015 Dec;43(12):1956-9.

Impact of Cationic Amino Acid Transporter 1 on Blood-Retinal Barrier Transport of L-Ornithine.
Kubo Y, Obata A, Akanuma S, Hosoya K.
Invest Ophthalmol Vis Sci. 2015 Sep 1;56(10):5925-32.

Organic cation transporter function in different in vitro models of human lung epithelium.
Salomon JJ, Gausterer JC, Yahara T, Hosoya K, Huwer H, Hittinger M, Schneider-Daum N, Lehr CM, Ehrhardt C.
Eur J Pharm Sci. 2015 Dec 1;80:82-8.

Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H(+) Gradient.
Tega Y, Kubo Y, Yuzurihara C, Akanuma S, Hosoya K.
J Pharm Sci. 2015 Sep;104(9):3069-75.

Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1.
Salomon JJ, Hagos Y, Petzke S, Kühne A, Gausterer JC, Hosoya K, Ehrhardt C.
Mol Pharm. 2015 Aug 3;12(8):2633-41.

Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood-Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina.
Sakurai T, Akanuma S, Usui T, Kubo Y, Tachikawa M, Hosoya K.
Biol Pharm Bull. 2015;38(7):1087-91.

In vitro study of L-glutamate and L-glutamine transport in retinal pericytes: involvement of excitatory amino Acid transporter 1 and alanine-serine-cysteine transporter 2.
Akanuma S, Zakoji N, Kubo Y, Hosoya K.
Biol Pharm Bull. 2015;38(6):901-8.

Transporter-mediated L-glutamate elimination from cerebrospinal fluid: possible involvement of excitatory amino acid transporters expressed in ependymal cells and choroid plexus epithelial cells.
Akanuma SI, Sakurai T, Tachikawa M, Kubo Y, Hosoya KI.
Fluids Barriers CNS. 2015 Apr 29;12(1):11.

Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.
Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma SI, Hosoya KI, Tamai I.
PLoS One. 2015 Apr 29;10(4):e0123895.

Involvement of cationic amino Acid transporter 1 in L-arginine transport in rat retinal pericytes.
Zakoji N, Akanuma S, Tachikawa M, Hosoya K.
Biol Pharm Bull. 2015;38(2):257-62.

Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood-brain barrier endothelial cells.
Kaneko Y, Tachikawa M, Akaogi R, Fujimoto K, Ishibashi M, Uchida Y, Couraud PO, Ohtsuki S, Hosoya K, Terasaki T.
J Pharmacol Exp Ther. 2015 Apr;353(1):192-200.

Involvement of the h+/organic cation antiporter in nicotine transport in rat liver.
Tega Y, Akanuma S, Kubo Y, Hosoya K.
Drug Metab Dispos. 2015 Jan;43(1):89-92.

Pharmacological significance of prostaglandin e₂ and d₂ transport at the brain barriers.
Tachikawa M, Hosoya K, Terasaki T.
Adv Pharmacol. 2014;71:337-60.

Involvement of carrier-mediated transport in the retinal uptake of clonidine at the inner blood-retinal barrier.
Kubo Y, Tsuchiyama A, Shimizu Y, Akanuma S, Hosoya K.
Mol Pharm. 2014 Oct 6;11(10):3747-53.

Transporter-mediated Prostaglandin E₂ Elimination across the Rat Blood-brain Barrier and Its Attenuation by the Activation of N-methyl-D-aspartate Receptors.
Akanuma S, Higuchi T, Higashi H, Ozeki G, Tachikawa M, Kubo Y, Hosoya K.
Drug Metab Pharmacokinet. 2014 Oct 25;29(5):387-93.

Impact of P-glycoprotein on blood-retinal barrier permeability: comparison of blood-aqueous humor and blood-brain barrier using mdr1a knockout rats.
Fujii S, Setoguchi C, Kawazu K, Hosoya K.
Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8.

Distribution of microsomal prostaglandin E synthase-1 in the mouse brain.
Eskilsson A, Tachikawa M, Hosoya K, Blomqvist A.
J Comp Neurol. 2014 Dec 1;522(14):3229-44.

Involvement of the carrier-mediated process in the retina-to-blood transport of spermine at the inner blood-retinal barrier.
Kubo Y, Tomise A, Tsuchiyama A, Akanuma SI, Hosoya KI.
Exp Eye Res. 2014 May 14;124:17-23.

Amino Acid Residues Involved in the Substrate Specificity of TauT/SLC6A6 for Taurine and γ-Aminobutyric Acid.
Yahara T, Tachikawa M, Akanuma S, Kubo Y, Hosoya K.
Biol Pharm Bull. 2014;37(5):817-25.

The cutting-edge of clinical therapeutics based on pharmacokinetic/pharmacodynamic theory. Preface.
Hosoya K, Inoue K.
Drug Metab Pharmacokinet. 2014;29(1):3.

Pharmacokinetics of guanidinosuccinic acid in rat blood and cerebrospinal fluid.
Kasai Y, Akanuma S, Kubo Y, Tachikawa M, Hosoya K.
Drug Metab Pharmacokinet. 2014;29(1):97-100.

The verapamil transporter expressed in human alveolar epithelial cells (A549) does not interact with β2-receptor agonists.
Salomon JJ, Ehrhardt C, Hosoya K.
Drug Metab Pharmacokinet. 2014;29(1):101-4.

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.
Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T.
Mol Pharm. 2013;10:289-96.

Localization of organic anion transporting polypeptide (Oatp) 1a4 and Oatp1c1 at the rat blood-retinal barrier.
Akanuma S, Hirose S, Tachikawa M, Hosoya K.
Fluids Barriers CNS. 2013 Oct 2;10(1):29.

β-alanine and l-histidine transport across the inner blood-retinal barrier: potential involvement in L-carnosine supply.
Usui T, Kubo Y, Akanuma S, Hosoya K.
Exp Eye Res. 2013 Aug;113:135-42.

Propranolol transport across the inner blood-retinal barrier: potential involvement of a novel organic cation transporter.
Kubo Y, Shimizu Y, Kusagawa Y, Akanuma S, Hosoya K.
J Pharm Sci. 2013 Sep;102(9):3332-42.

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy.
Devi TS, Hosoya K, Terasaki T, Singh LP.
Exp Cell Res. 2013 Apr 15;319(7):1001-12.

Na⁺-independent nucleoside transporters regulate adenosine and hypoxanthine levels in Müller cells and the inner blood-retinal barrier.
Akanuma S, Soutome T, Hisada E, Tachikawa M, Kubo Y, Hosoya K.
Invest Ophthalmol Vis Sci. 2013 Feb 27;54(2):1469-77.

Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process.
Tega Y, Akanuma S, Kubo Y, Terasaki T, Hosoya K.
Neurochem Int. 2013 Jan;62(2):173-81.

Involvement of a novel organic cation transporter in verapamil transport across the inner blood-retinal barrier.
Kubo Y, Kusagawa Y, Tachikawa M, Akanuma S, Hosoya K.
Pharm Res. 2013 Mar;30(3):847-56.

久保義行，赤沼伸乙，細谷健一: カチオン性薬物輸送に見る血液網膜関門と血液脳関門の類似と相違．細胞工学．2013；32：950-4.

立川正憲，赤沼伸乙，寺崎哲也: 脳関門プロスタグランジン輸送の分子病態生理．細胞工学．2013；32：946-9.

The inner blood-retinal barrier: molecular structure and transport biology.
Hosoya K, Tachikawa M.
Adv Exp Med Biol. 2012;763:85-104.

Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E₂ produced in the brain.
Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K.
J Neurochem. 2012 Dec;123(5):750-60.

Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data.
Nakamori F, Naritomi Y, Hosoya K, Moriguchi H, Tetsuka K, Furukawa T, Kadono K, Yamano K, Terashita S, Teramura T.
Drug Metab Dispos. 2012 Sep;40(9):1771-7.

Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats.
Ikeda S, Tachikawa M, Akanuma S, Fujinawa J, Hosoya K.
Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G291-7.

Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes.
Chen Y, Wang JJ, Li J, Hosoya KI, Ratan R, Townes T, Zhang SX.
Diabetologia. 2012 Sep;55(9):2533-45.

Application of membrane permeability evaluated in in vitro analyses to estimate blood-retinal barrier permeability.
Kubo Y, Fukui E, Akanuma S, Tachikawa M, Hosoya K.
J Pharm Sci. 2012 Jul;101(7):2596-605.

Function and regulation of taurine transport in Müller cells under osmotic stress.
Ando D, Kubo Y, Akanuma S, Yoneyama D, Tachikawa M, Hosoya K.
Neurochem Int. 2012 May;60(6):597-604.

γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.
Tachikawa M, Ikeda S, Fujinawa J, Hirose S, Akanuma S, Hosoya K.
PLoS One. 2012;7(2):e32557.

Up-regulation of L-type amino acid transporter 1 (LAT1) in cultured rat retinal capillary endothelial cells in response to glucose deprivation.
Matsuyama R, Tomi M, Akanuma S, Tabuchi A, Kubo Y, Tachikawa M, Hosoya K.
Drug Metab Pharmacokinet. 2012;27(3):317-24.

Kubo Y., and Hosoya K. : Inner blood-retinal barrier transporters: relevance to diabetic retinopathy, In Diabetic Retinopathy, by Ola M.S.(Ed), 91-108, InTech, Croatia, 2012.

Tachikawa M., Hosoya K., Smith S.B., Martin P.M., and Ganapathy V. : Transport of drugs across the inner and outer blood-retinal barriers: relevance of transporters in the retinal blood vessel endothelium and the retinal pigment epithelium, In Advances in Ocular Drug Delivery, by Mitra A.K.(Ed), 1-31, Research Signpost Publication, Kerala, 2012.

Hosoya K., and Tachikawa M. : The inner blood-retinal barrier: molecular structure and transport biology, In Biology and Regulation of Blood-Tissue Barriers, by Cheng C.Y.(Ed), 85-104, Springer, New York, 2012.

細谷健一 : 薬物の分布. 「パートナー薬剤学 改訂第2版」寺田勝英, 伊藤智夫編, 162-177, 南江堂, 東京, 2012.

細谷健一 : 血液網膜関門輸送系の分子機構と薬物輸送. 眼薬理, 26: 50-53, 2012.

久保義行, 赤沼伸乙, 細谷健一 : 血液網膜関門の機能特性を利用したドラッグデリバリー. Drug Delivery Syst., 27: 361-369, 2012.

Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier.
Hosoya K, Tomi M, Tachikawa M.
Expert Opin Drug Deliv. 2011 Dec;8(12):1571-87.

Attenuation of prostaglandin E₂ elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.
Akanuma S, Uchida Y, Ohtsuki S, Tachikawa M, Terasaki T, Hosoya K.
Fluids Barriers CNS. 2011 Oct 21;8:24.

Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.
Akanuma S, Uchida Y, Ohtsuki S, Kamiie J, Tachikawa M, Terasaki T, Hosoya K.
Drug Metab Pharmacokinet. 2011;26(6):602-11.

Regulation of glutamate metabolism by hydrocortisone and branched chain keto acids in cultured rat retinal Müller cells (TR-MUL).
Ola MS, Hosoya K, LaNoue KF.
Neurochem Int. 2011 Oct;59(5):656-63.

Retinal transfer of nicotinate by H⁺ -monocarboxylate transporter at the inner blood-retinal barrier.
Tachikawa M, Murakami K, Martin PM, Hosoya K, Ganapathy V.
Microvasc Res. 2011 Nov;82(3):385-90.

Influence of insulin on glutamine synthetase in the Müller glial cells of retina.
Ola MS, Hosoya K, LaNoue KF.
Metab Brain Dis. 2011 Sep;26(3):195-202.

Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins.
Hosoya K, Tachikawa M.
Clin Exp Nephrol. 2011 Aug;15(4):478-85.

Transport systems of serine at the brain barriers and in brain parenchymal cells.
Kasai Y, Tachikawa M, Hirose S, Akanuma S, Hosoya K.
J Neurochem. 2011 Jul;118(2):304-13.

Inner blood-retinal barrier mediates l-isomer-predominant transport of serine.
Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma S, Terasaki T, Hosoya K.
J Pharm Sci. 2011 Sep;100(9):3892-903.

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier.
Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T.
J Neurochem. 2011 Aug;118(3):407-15.

GSK-3β/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implications for diabetic retinopathy.
Devi TS, Singh LP, Hosoya K, Terasaki T.
Biochim Biophys Acta. 2011 Sep;1812(9):1080-8.

Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders.
Tachikawa M, Hosoya K.
Fluids Barriers CNS. 2011 Feb 28;8(1):13.

Reactive oxygen species downregulate glucose transport system in retinal endothelial cells.
Fernandes R, Hosoya K, Pereira P.
Am J Physiol Cell Physiol. 2011 Apr;300(4):C927-36.

Response of rat retinal capillary pericytes and endothelial cells to glucose.
Makita J, Hosoya K, Zhang P, Kador PF.
J Ocul Pharmacol Ther. 2011 Feb;27(1):7-15.

Tachikawa M., Ganapathy V., and Hosoya K. : Systemic route for retinal drug　delivery: role of the blood-retinal barrier, In Drug Product Development for the Back of the Eye, by Kompella U.B. and Edelhauser H.F.(Ed.), 85-109, Springer, New York, 2011.

大塚　誠，細谷健一：製剤の種類.「わかりやすい物理薬剤学」第5版，辻　彰，河島　進編, 187-191, 廣川書店, 東京, 2011.

細谷健一，大塚　誠：製剤の種類.「わかりやすい物理薬剤学」第5版，辻　彰，河島　進編, 192-210, 廣川書店, 東京, 2011.

寺崎哲也，大槻純男，久保義行，内田康雄，大峰　健：定量的トランスポーター解析のための質量分析による膜タンパク質絶対定量法.「トランスポートソームの世界」金井好克，竹島　浩，森泰生，久保義弘編, 405-410, 京都廣川書店, 東京, 2011.

Tachikawa M., and Hosoya K. : Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders. Fluids Barriers CNS, 8:13, 2011.

Hosoya K., and Tachikawa M. : Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins. Clin. Exp. Nephrol., 15: 478-485, 2011.

Hosoya K., Tomi M., and Tachikawa M. : Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier. Expert. Opin. Drug Deliv., 8: 1571-1587, 2011.

Ohtsuki S., Uchida Y., Kubo Y., and Terasaki T. : Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. J. Pharm. Sci., 100: 3547-3559, 2011.