原著論文

Hosoya K, Tachikawa M.
The inner blood-retinal barrier: molecular structure and transport biology.
Adv Exp Med Biol. 2012;763:85-104.

Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K.
Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E₂ produced in the brain.
J Neurochem. 2012 Dec;123(5):750-60.

Nakamori F, Naritomi Y, Hosoya K, Moriguchi H, Tetsuka K, Furukawa T, Kadono K, Yamano K, Terashita S, Teramura T.
Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data.
Drug Metab Dispos. 2012 Sep;40(9):1771-7.

Ikeda S, Tachikawa M, Akanuma S, Fujinawa J, Hosoya K.
Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats.
Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G291-7.

Chen Y, Wang JJ, Li J, Hosoya KI, Ratan R, Townes T, Zhang SX.
Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes.
Diabetologia. 2012 Sep;55(9):2533-45.

Kubo Y, Fukui E, Akanuma S, Tachikawa M, Hosoya K.
Application of membrane permeability evaluated in in vitro analyses to estimate blood-retinal barrier permeability.
J Pharm Sci. 2012 Jul;101(7):2596-605.

Ando D, Kubo Y, Akanuma S, Yoneyama D, Tachikawa M, Hosoya K.
Function and regulation of taurine transport in Müller cells under osmotic stress.
Neurochem Int. 2012 May;60(6):597-604.

Tachikawa M, Ikeda S, Fujinawa J, Hirose S, Akanuma S, Hosoya K.
γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.
PLoS One. 2012;7(2):e32557.

Matsuyama R, Tomi M, Akanuma S, Tabuchi A, Kubo Y, Tachikawa M, Hosoya K.
Up-regulation of L-type amino acid transporter 1 (LAT1) in cultured rat retinal capillary endothelial cells in response to glucose deprivation.
Drug Metab Pharmacokinet. 2012;27(3):317-24.

著書・総説

Kubo Y., and Hosoya K. : Inner blood-retinal barrier transporters: relevance to diabetic retinopathy, In Diabetic Retinopathy, by Ola M.S.(Ed), 91-108, InTech, Croatia, 2012.

Tachikawa M., Hosoya K., Smith S.B., Martin P.M., and Ganapathy V. : Transport of drugs across the inner and outer blood-retinal barriers: relevance of transporters in the retinal blood vessel endothelium and the retinal pigment epithelium, In Advances in Ocular Drug Delivery, by Mitra A.K.(Ed), 1-31, Research Signpost Publication, Kerala, 2012.

Hosoya K., and Tachikawa M. : The inner blood-retinal barrier: molecular structure and transport biology, In Biology and Regulation of Blood-Tissue Barriers, by Cheng C.Y.(Ed), 85-104, Springer, New York, 2012.

細谷健一 : 薬物の分布. 「パートナー薬剤学 改訂第2版」寺田勝英, 伊藤智夫編, 162-177, 南江堂, 東京, 2012.

細谷健一 : 血液網膜関門輸送系の分子機構と薬物輸送. 眼薬理, 26: 50-53, 2012.

久保義行, 赤沼伸乙, 細谷健一 : 血液網膜関門の機能特性を利用したドラッグデリバリー. Drug Delivery Syst., 27: 361-369, 2012.