原著論文

Hosoya K, Tomi M, Tachikawa M.
Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier.
Expert Opin Drug Deliv. 2011 Dec;8(12):1571-87.

Akanuma S, Uchida Y, Ohtsuki S, Tachikawa M, Terasaki T, Hosoya K.
Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.
Fluids Barriers CNS. 2011 Oct 21;8:24.

Akanuma S, Uchida Y, Ohtsuki S, Kamiie J, Tachikawa M, Terasaki T, Hosoya K.
Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.
Drug Metab Pharmacokinet. 2011;26(6):602-11.

Ola MS, Hosoya K, LaNoue KF.
Regulation of glutamate metabolism by hydrocortisone and branched chain keto acids in cultured rat retinal Müller cells (TR-MUL).
Neurochem Int. 2011 Oct;59(5):656-63.

Tachikawa M, Murakami K, Martin PM, Hosoya K, Ganapathy V.
Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier.
Microvasc Res. 2011 Nov;82(3):385-90.

Ola MS, Hosoya K, LaNoue KF.
Influence of insulin on glutamine synthetase in the Müller glial cells of retina.
Metab Brain Dis. 2011 Sep;26(3):195-202.

Hosoya K, Tachikawa M.
Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins.
Clin Exp Nephrol. 2011 Aug;15(4):478-85.

Kasai Y, Tachikawa M, Hirose S, Akanuma S, Hosoya K.
Transport systems of serine at the brain barriers and in brain parenchymal cells.
J Neurochem. 2011 Jul;118(2):304-13.

Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma S, Terasaki T, Hosoya K.
Inner blood-retinal barrier mediates l-isomer-predominant transport of serine.
J Pharm Sci. 2011 Sep;100(9):3892-903.

Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T.
Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier.
J Neurochem. 2011 Aug;118(3):407-15.

Devi TS, Singh LP, Hosoya K, Terasaki T.
GSK-3β/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implications for diabetic retinopathy.
Biochim Biophys Acta. 2011 Sep;1812(9):1080-8.

Tachikawa M, Hosoya K.
Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders.
Fluids Barriers CNS. 2011 Feb 28;8(1):13.

Fernandes R, Hosoya K, Pereira P.
Reactive oxygen species downregulate glucose transport system in retinal endothelial cells.
Am J Physiol Cell Physiol. 2011 Apr;300(4):C927-36.

Makita J, Hosoya K, Zhang P, Kador PF.
Response of rat retinal capillary pericytes and endothelial cells to glucose.
J Ocul Pharmacol Ther. 2011 Feb;27(1):7-15.

著書・総説

Tachikawa M., Ganapathy V., and Hosoya K. : Systemic route for retinal drug　delivery: role of the blood-retinal barrier, In Drug Product Development for the Back of the Eye, by Kompella U.B. and Edelhauser H.F.(Ed.), 85-109, Springer, New York, 2011.

大塚　誠，細谷健一：製剤の種類.「わかりやすい物理薬剤学」第5版，辻　彰，河島　進編, 187-191, 廣川書店, 東京, 2011.

細谷健一，大塚　誠：製剤の種類.「わかりやすい物理薬剤学」第5版，辻　彰，河島　進編, 192-210, 廣川書店, 東京, 2011.

寺崎哲也，大槻純男，久保義行，内田康雄，大峰　健：定量的トランスポーター解析のための質量分析による膜タンパク質絶対定量法.「トランスポートソームの世界」金井好克，竹島　浩，森泰生，久保義弘編, 405-410, 京都廣川書店, 東京, 2011.

Tachikawa M., and Hosoya K. : Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders. Fluids Barriers CNS, 8:13, 2011.

Hosoya K., and Tachikawa M. : Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins. Clin. Exp. Nephrol., 15: 478-485, 2011.

Hosoya K., Tomi M., and Tachikawa M. : Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier. Expert. Opin. Drug Deliv., 8: 1571-1587, 2011.

Ohtsuki S., Uchida Y., Kubo Y., and Terasaki T. : Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. J. Pharm. Sci., 100: 3547-3559, 2011.