原著論文

Tomi M, Hosoya K.
Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier.
J Neurochem. 2004 Dec;91(5):1244-8.

Shiiki T, Ohtsuki S, Kurihara A, Naganuma H, Nishimura K, Tachikawa M, Hosoya K, Terasaki T.
Brain insulin impairs amyloid-beta(1-40) clearance from the brain.
J Neurosci. 2004 Oct 27;24(43):9632-7.

Hosoya K, Tomi M, Takayama M, Komokata Y, Nakai D, Tokui T, Nishimura K, Ueda M, Obinata M, Hori S, Ohtsuki S, Amidon GL, Terasaki T.
Transporter mRNA expression in a conditionally immortalized rat small intestine epithelial cell line (TR-SIE).
Drug Metab Pharmacokinet. 2004 Aug;19(4):264-9.

Hosoya K, Hori S, Ohtsuki S, Terasaki T.
A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat.
Adv Drug Deliv Rev. 2004 Oct 14;56(12):1875-85.

Fernandes R, Carvalho AL, Kumagai A, Seica R, Hosoya K, Terasaki T, Murta J, Pereira P, Faro C.
Downregulation of retinal GLUT1 in diabetes by ubiquitinylation.
Mol Vis. 2004 Aug 30;10:618-28.

Tomi M, Abukawa H, Nagai Y, Hata T, Takanaga H, Ohtsuki S, Terasaki T, Hosoya K.
Retinal selectivity of gene expression in rat retinal versus brain capillary endothelial cell lines by differential display analysis.
Mol Vis. 2004 Aug 9;10:537-43.

Ohtsuki S, Takizawa T, Takanaga H, Hori S, Hosoya K, Terasaki T.
Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.
J Neurochem. 2004 Aug;90(3):743-9.

Nakashima T, Tomi M, Katayama K, Tachikawa M, Watanabe M, Terasaki T, Hosoya K.
Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier.
J Neurochem. 2004 Jun;89(6):1454-61.

Hori S, Ohtsuki S, Hosoya K, Nakashima E, Terasaki T.
A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro.
J Neurochem. 2004 Apr;89(2):503-13.

Hosoya K, Minamizono A, Katayama K, Terasaki T, Tomi M.
Vitamin C transport in oxidized form across the rat blood-retinal barrier.
Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1232-9.

Deguchi Y, Naito Y, Ohtsuki S, Miyakawa Y, Morimoto K, Hosoya K, Sakurada S, Terasaki T.
Blood-brain barrier permeability of novel [D-arg2]dermorphin (1-4) analogs: transport property is related to the slow onset of antinociceptive activity in the central nervous system.
J Pharmacol Exp Ther. 2004 Jul;310(1):177-84.

著書・総説

Hosoya K.，Hori S.，Ohtsuki S.，and Terasaki T.: A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat. Adv. Drug Deliv. Rev.，56: 1875-1885，2004.