富山大学薬学部/大学院医学薬学研究部
薬品製造学研究室
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Laboratory of Synthetic and Medicinal Chemistry

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List of staff articles » Matsuya Sugimoto Tanioka

2024

  1. Coerulein B: a water-soluble and water-compatible near-infrared photoredox catalyst
    Tanioka, M.; Oyama, M.; Nakajima, K.; Mori, M.; Harada, M.; Matsuya, Y.; Kamino, S.
    Phys. Chem. Chem. Phys. 2024, accepted (doi: 10.1039/D3CP05585J).

2023

  1. Nucleophile-Triggered π-Topological Transformation: a New Synthetic Approach to Near-Infrared-Emissive Rhodamines.
    Harada, M.; Kutsuna, M.; Kitamura, T.; Usui, Y.; Ujiki, M; Nakamura, Y.; Obata, T.; Tanioka, M.; Uchiyama, M.; Sawada, D.; Kamino, S.
    Chem. Eur. J. 2023, e202301969 (doi: 10.1002/chem.202301969).
  2. Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity
    Kohyama, A.; Shiuchi, A.; Zhou, Y.; Tanioka, M.; Sugimoto, K.: Sakurai, H.; Matsuya, Y.
    Org. Biomol. Chem. 2023, 21, 4656-4660 (doi: 10.1039/D3OB00357D).
  3. One-Pot Synthesis of Pentasubstituted Pyridines following the Gold(I)-Catalyzed Aza–Enyne Metathesis/6π-Electrocyclization–Aromatization Sequence
    Kosuge, S.; Araki, Y.; Tsuge, K.; Sugimoto, K.; Matsuya, Y.
    J. Org. Chem. 2023, 88, 6973–6986 (doi: 10.1021/acs.joc.3c00270).
  4. DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies
    Kikuchi, S.; Wada, A.; Kamihara, Y.; Okazaki, K.; Jawaid, P.; Rehman, M. U.; Kobayashi, E.; Susukida, T; Minemura, T.; Nabe, Y.; Iwao, N.; Ozawa, T.; Hatano, Y.; Yamada, M.; Kishi, H.; Matsuya, Y.; Mizuguchi, M.; Hayakawa, Y.; Dang, N. H.; Sakamoto, Y.; Morimoto, C.; Sato, T.
    Cells 2023, 12, 1100 (doi: 10.3390/cells12071100).

2022

  1. Acceleration effect of mild organocatalytic system 2,2´-Biphenol/B(OH)3 for 2-aza-Cope rearrangement
    Sugimoto, K.; Yoshida, R.; Matsuya, Y.
    Tetrahedron Lett. 2022, 102, 153922 (doi:10.1016/j.tetlet.2022.153922).
  2. Structure-Activity Relationship and Mechanistic Study on Gugglesterone derivatives; Discovery of New Anti-pancreatic Cancer Candidate
    Kohyama, A.; Kim, M. J.; Yokoyama, R.; Sun, S.; Omar, A. M.; Phan, N. D.; Meselhy, M. R.; Tsuge, K.; Awale, S.; Matsuya, Y.
    Bioorg. Med. Chem. 2022, 54, 116563 (doi: 10.1016/j.bmc.2021.116563).
  3. Visualization of the photodegradation of a therapeutic drug by chemometric-assisted fluorescence spectroscopy
    Tanioka, M.; Ebihana, T.; Uraguchi, M.; Shoji, H.; Nakamura, Y.; Ueda, R.; Ogura, S.; Wakiya, Y.; Obata, T.; Ida, T.; Horigome, J.; Kamino, S.
    RSC Adv. 2022, 12, 20714-20720 (DOI:10.1039/d2ra03534k)
  4. Bridged eosin Y: a visible and near-infrared photoredox catalyst
    Tanioka, M.; Kuromiya, A.; Ueda, R.; Obata, T.; Muranaka, A.; Uchiyama, M.; Kamino, S.
    Chem. Commun. 2022, 58, 7825-7828 (DOI:10.1039/d2cc02907c)

2021

  1. Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008
    Fujii, T.; Sugimoto, K.; Noda, T.; Shimizu, T.; Matsuya, Y.; Sakai, H.
    Biochem. Biophys. Res. Commun. 2021, 567, 177-182 (doi: org/10.1016/j.bbrc.2021.06.056)
  2. Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells
    Abdellatef, A. A.; Zhou, Y.; Yamada, A.; Elmekkawy, S. A.; Kohyama, A.; Yokoyama, S.; Meselhy, M. R.; Matsuya, Y.; Sakurai, H.; Hayakawa, Y.
    Biomed. Pharmacother. 2021, 140, 111737 (doi: 10.1016/j.biopha.2021.111737)
  3. Au(I) Catalyzed Synthesis of Densely Substituted Pyrazolines and Dihydropyridines via Sequential Aza-Enyne Metathesis/6π-Electrocyclization
    Sugimoto, K.; Kosuge, S.; Sugita, T.; Miura, Y.; Tsuge, K.; Matsuya, Y.
    Org. Lett. 2021, 23, 3981-3985 (doi: 10.1021/acs.orglett.1c01171)
  4. Divinylcarbinol Desymmetrization Strategy: A Concise and Reliable Approach to Chiral Hydroxylated Fatty Acid Derivatives.
    Sugimoto, K.; Kobayashi, A.; Kohyama, A.; Sakai, H.; Matsuya, Y.
    J. Org. Chem. 2021, 86, 3970-3980 (doi: org/10.1021/acs.joc.0c02821)
  5. Morpholine‐Substituted Rhodamine Analogue with Multi‐Configurational Switches for Optical Sensing of pH Gradient under Extreme Acidic Environments
    Koga, N.; Tanioka, M.; Kamino, S.; Sawada, D.
    Chem. Eur. J. 2021, 27, 3761-3765 (DOI:10.1002/chem.202004254)
  6. cis-3-Azido-2-methoxyindolines as safe and stable precursors to overcome the instability of fleeting 3-azidoindoles
    Yamashiro, T.; Abe, T.; Tanioka, M.; Kamino, S.; Sawada D.
    Chem. Commun. 2021, 57, 13381-13384 (DOI:10.1039/d1cc06033c)

2020

  1. De Novo Approach to Izidines via a Gold-Catalyzed Hydroamination–N-acyliminium Ion Cyclization of Acyclic Ynamides.
    Sugimoto, K.; Mizuno, S.; Shirato, M.; Tanabe, K.; Matsuya, Y.
    Heterocycles 2020, 103, 526-543. doi: 10.3987/COM-20-S(K)38
  2. Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells.
    Kohyama, A.; Yokoyama, R.; Dibwe, D. F.; El-Mekkawy, S.; Meselhy, M. R.; Awale, S.; Matsuya, Y.
    Bioorg. Med. Chem. Lett. 2020, 30, 126964. doi: 10.1016/j.bmcl.2020.126964.
  3. A remarkably air-stable quinodimethane radical cation
    Harada, M.; Tanioka, M.; Muranaka, A.; Aoyama, T.; Kamino, S.; Uchiyama M.
    Chem. Comm. 2020, 56, 9565-9568 (DOI:10.1039/d0cc04025h)
  4. Stepwise structural and fluorescent colour conversion in rhodamine analogues based on light and acid stimulations
    Tanioka, M.; Kamino, S.; Koga, N.; Sawada D.
    J. Mat. Chem. C 2020, 8, 543-549 (DOI:10.1039/d0cc04025h)

2019

  1. 2,2 -Biphenol/B(OH)3 Catalyst System for Nazarov Cyclization.
    Sugimoto, K.; Oshiro, M.; Hada, R.; Matsuya, Y.
    Chem. Pharm. Bull. 2019, 67, 1019-1022. doi:org/10.1248/cpb.c19-00399.
  2. An Improved Synthesis of a Salicylated Divinylcarbinol Derivative as a Part of Salicylic Macrolides.
    Kohyama, A.; Oguma, Y.; Yamagishi, T.; Sugimoto, K.; Matsuya, Y.
    Heterocycles, 2020, 100, 137-140, doi:10.3987/COM-19-14120.
  3. Facile o-Quinodimethane Formation from Benzocyclobutenes Triggered by Staudinger Reaction at Ambient Temperature.
    Kohyama, A.; Koresawa, E.; Tsuge, K.; Matsuya, Y.
    Chem. Comm. 2019, 55, 6205-6208. doi:org/10.1039/C9CC01679A
  4. Recent Application of ortho-Quinodimethane Chemistry for Synthesis of Heterocyclic Compounds.
    Matsuya, Y.
    Heterocycles, 2019, 98, 621-635. doi:10.3987/REV-19-908.
  5. Synthetic Studies on Pyrroloindolizidine Skeleton Based on Gold—Catalyzed Hydroamination—Enamine Cyclization—Ring—Closing Metathesis Strategy.
    Sugimoto, K.; Matsuo, N.; Tominaga, D.; Matsuya, Y.
    Heterocycles 2019, 99, 875-890. (DOI:10.3987/COM-18-S(F)56).
  6. Alkynylboration Reaction Leading to Boron-containing π-Extended cis-Stilbenes as a Highly Tunable Fluorophore
    Nogami, M.; Hirano, K.; Morimoto, K.; Tanioka, M.; Miyamoto, K.; Muranaka, A.; Uchiyama, M.
    Org. Lett. 2019, 21, 3392-3395 (DOI:10.1021/acs.orglett.9b01132)

2018

  1. Synthetic Studies Toward Isoschizogamine: Construction of Pentacyclic Core Structure.
    Sugimoto, K.; Fujiwara, H.; Takada, A.; Kim, D.-G.; Ueda, H.; Tokuyama, H.
    Heterocycles, 2018, 97, 1028-1049. doi:10.3987/COM-18-S(T)18.
  2. Acetic Acid, 2-[(1,1-Dimethylethyl)dimethylsilyl]-2-oxo-, Phenylmethyl ester.
    Sugimoto, K.; Matsuya, Y.
    eEROS, 2018. doi.org/10.1002/047084289X.rn02232.
  3. Free Radical Generation by Non-equilibrium Atmospheric Pressure Plasma in Alcohol-water Mixtures: An EPR-spin Trapping Study.
    Uchiyama, H.; Ishikawa, K.; Zhao, Q.-L.; Andocs, G.; Nojima, N.; Takeda, K.; Krishna, M. ; Ishijima, T.; Matsuya, Y.; Hori, M.; Noguchi, K.; Kondo, T.
    J. Phys. D: Appl. Phys., 2018, 51, 9, 095202.
  4. Stereoselective Synthesis of a Pivotal Chiral Intermediate for Natural Salicylic Macrolides.
    Oguma, Y.; Yamamoto, N.; Sugimoto, K.; Matsuya, Y.
    Heterocycles, 2018, 97, 283-291. doi:10.3987/COM-18-S(T)18.
  5. Stable Thiele’s Hydrocarbon Derivatives Exhibiting Near-Infrared Absorption/Emission and Two-Step Electrochromism
    Okamoto, Y.; Tanioka, M.; Muranaka, A.; Miyamoto, K.; Aoyama, T.; Ouyang, X.; Kamino, S.; Sawada D.; Uchiyama, M.
    J. Am. Chem. Soc. 2018, 140, 17857-17861 (DOI:10.1021/jacs.8b11092)

2017

  1. Recent Applications of Gold-catalyzed Cascade Reactions in Total Synthesis of Natural Product.
    Sugimoto, K.; Matsuya, Y.
    Tetrahedron Lett. 2017, 58, 4420-4426.
    (Most Downloaded Tetrahedron Letters Articles. 2018. 01)
  2. Synthetic Study towards Construction of Potential Scaffold of Antitumor Agents Andrastins.
    Yin, S.; Sugimoto, K.; Nemoto, H.; Matsuya, Y.
    Heterocycles, 2017, 95, 187-199.
  3. Syntheses and Photophysical Properties of Aminobenzopyranoxanthene Dyes Containing Various Alkyl Chains at Amine Moieties
    Kamino, S.; Tanioka, M.; Sawada D.; Enomoto, S.
    HETEROCYCLES, 2017, 95, 1167-1176 (DOI:10.3987/com-16-s(s)65)
  4. Water-tunable solvatochromic and nanoaggregate fluorescence: dual colour visualisation and quantification of trace water in tetrahydrofuran
    Tanioka, M.; Kamino, S.; Muranaka, A.; Shirasaki, Y.; Ooyama, Y.; Ueda, M.; Uchiyama, M.; Enomoto, S.; Sawada D.
    Phys. Chem. Chem. Phys. 2017, 19, 1209-1216 (DOI:10.1039/c6cp06808a)

2016

  1. Construction of cis-Fused Hydrindane Skeleton with a Lactone Tether Utilizing Intramolecular Diels-Alder Reaction.
    Yin, S.; Takai, K.; Minato, D.; Sugimoto, K.; Ohtsu, H.; Tsuge, K.; Matsuya, Y.
    Heterocycles, 2016, 93, 783-791.
  2. A Macrosphelide as the Unexpected Product of a Pleurotus Ostreatus Strain-mediated Biotransformation of Halolactones containing the gem-dimethylcyclohexane Ring. Part 1
    Wińska, K.; Mączka, W.; Grabarczyk, M.; Sugimoto, K.; Matsuya, Y.; Szumny, A.; Aniol, M.
    Molecules, 2016, 21, 859.
  3. A Novel Method for Determining Peroxisomal Fatty Acid β-Oxidation.
    Morita, M.; Matsumoto, S.; Okazaki, A.; Tomita, K.; Watanabe, S.; Kawaguchi, K.; Minato, D.; Matsuya, Y.; Shimozawa, N.; Imanaka, T.
    J. Inherit. Metab. Dis., 2016, 39, 725-731.
  4. Highly Efficient Access to Both Geometric Isomers of Silyl Enol Ethers: Sequential 1,2-Brook/Wittig Reactions.
    Matsuya, Y.; Wada, K.; Minato, D.; Sugimoto, K.
    Angew. Chem. Int. Ed. 2016, 55, 10079-10082.
  5. Synthesis of Substituted Pyrrolo[2,1-a]isoquinolines by Gold-catalyzed Domino Cyclization of Alkynyl Iminoesters.
    Sugimoto, K.; Hoshiba, Y.; Tsuge, K.; Matsuya, Y.
    Synthesis, 2016, 48, 1855-1864.
  6. Synthesis of Substituted Quinolizidines via Gold-Catalyzed Double Cyclization Cascade.
    Nonaka, S.; Sugimoto, K.; Ueda, H.; Tokuyama, H.
    Adv. Synth. Catal. 2016, 358, 380-385 (VIP article), Selected as Inside Cover
  7. In vitro and in vivo Antiherpetic Effects of (1R,2R)-1-(5'-methylful-3'-yl)propane-1,2,3-triol.
    Sasaki, K.; Hayashi, K.; Matsuya, Y.; Sugimoto, K.; Lee, J.-B.; Kurosaki, F.; Hayashi, T.
    J. Nat. Med. 2016, 70, 217-224.

2015

  1. Total Synthesis of (—)-Isoschizogamine.
    Takada, A.; Fujiwara, H.; Sugimoto, K.; Ueda, H.; Tokuyama, H.
    Chem. Eur. J. 2015, 21, 16400-16403.
  2. Synthesis of Denosomin&mdashVitamin D3 Hybrids and Evaluation of their Anti-Alzheimer's Disease Activities.
    Sugimoto, K.; Yajima, H.; Hayashi, Y.; Minato, D.; Terasaki, S.; Tohda, C.; Matsuya, Y.
    Org. Lett. 2015, 17, 5910-5913.
  3. Three-Component Domino Process for Pyrrolizine Skeleton via [3+2]-Cycloaddition—Enamine Cyclization Triggered by Gold Catalyst.
    Sugimoto, K.; Yamamoto, N.; Tominaga, D.; Matsuya, Y.
    Org. Lett. 2015, 17, 1320-1323.
  4. Total Synthesis of (—)-Rhazinilam using 1,3-Dipolar Cycloaddition of Optically Active Munchnone Intermediate.
    Sugimoto, K.; Miyakawa, Y.; Tokuyama, H.
    Tetrahedron 2015, 71, 3619-3624.
  5. Preparation of (2R,4S)/(2S,4S)-4-Hydroxypipecolinic Acid Derivatives from L-(—)-Malic Acid.
    Yin, S.; Taneda, H.; Li, B.; Zhou, D.; Minato, D.; Sugimoto, K.; Matsuya, Y.
    Heterocycles 2015, 90, 928-938.
  6. Synthesis and Evaluations of GLP-1 Secretion and Anti-Diabetic Effect in KKAy Mice of New Tricyclic Compounds.
    Minehira, D.; Takeda, D.; Miyawaki, S.; Kato, A.; Adachi, I.; Miyazaki, A.; Miyatake, R.; Umezaki, M.; Miura, K.; Kitahara, Y.; Sugimoto, K.; Matsuya, Y.; Toyooka N.
    Heterocycles 2015, 90, 372-404.
  7. Reversible Near-Infrared/Blue Mechanofluorochromism of Aminobenzopyranoxanthene
    Tanioka, M.; Kamino, S.; Muranaka, A.; Ooyama, Y.; Ota, H.; Shirasaki, Y.; Horigome, J.; Ueda, M.; Uchiyama, M.; Sawada, D.; Enomoto. S.
    J. Am. Chem. Soc. 2015, 137, 6436-6439 (DOI:10.1021/jacs.5b00877)

2014

  1. Auto Tandem Catalysis: Synthesis of Pyrroles by Gold-Catalyzed Reaction.
    Ueda, H.; Yamaguchi, M.; Kameya, H.; Sugimoto, K.; Tokuyama, H.
    Org. Lett. 2014, 16, 4948-4951.
  2. Total Synthesis (—)-Haouamine B pentaacetate and Structural Revision of Haouamine B.
    Momoi, Y.; Okuyama, K.; Toya, H.; Sugimoto, K.; Okano, K.; Tokuyama, H.
    Angew. Chem. Int. Ed. 2014, 53, 13215-13219.
  3. Stereoselective Approach to Potential Scaffold of A-nor B-aromatic OSW-1 analogues via [4+2] Cycloaddition of o-Quinodimethane
    Li, B.; Masuda, S.; Minato, D.; Zhou, D.; Sugimoto, K.; Nemoto, H.; Matsuya, Y.
    Tetrahedron 2014, 70, 3981-3987.
  4. Synthesis of 8-Amino-(dihydrofuran-fused perhydrophenanthrene) via Copper-Mediated Amination Reaction.
    Sugimoto, K.; Tamura, K.; Toyooka, N.; Matsuya, Y.
    Heterocycles 2014, 88, 755-763 (Victor Snieckus's Special Issue).
  5. Synthesis of Long-chain Fatty Acid Derivatives as a Novel Anti-Alzheimer's Agent
    Zhang, H-Y.; Yamakawa, Y.; Matsuya, Y.; Toyooka, N.; Tohda, C.; Awale, S.; Li, F.; Kadota, S.; Tezuka, Y.
    Bioorg. Med. Chem. Lett. 2014, 24, 604-608.
  6. Design and Syntheses of Highly Emissive Aminobenzopyrano-xanthene Dyes in the Visible and Far-Red Regions
    Kamino, S.; Murakami, M.; Tanioka, M.; Shirasaki, Y,; Watanabe, K.; Horigome, J.; Ooyama, Y.; Enomoto S.
    Org. Lett. 2014, 16, 258-261 (DOI:10.1021/ol403262x)

2013

  1. Synthesis of Phenylalkyl-substituted Polyhydroxypiperidines as Potent Inhibitors for α-L-fucosidase.
    Saka, T.; Okaki, T.; Ifuku, S.; Yamashita, Y.; Sato, K.; Miyawaki, S.; Kamori, A.; Kato, A.; Adachi, I.; Tezuka, Y.; Kiria, P. G.; Onomura, O.; Minato, D.; Sugimoto, K.; Matsuya, Y.; Toyooka N.
    Tetrahedron 2013, 69, 10653-10661.
  2. Synthesis and Structure-activity Relationship of 2-Phenyliminochromene Derivatives as Inhibitors for Aldo-keto Reductase (AKR) 1B10.
    Endo, S.; Hu, D.; Suyama, M.; Matsunaga, T.; Sugimoto, K.; Matsuya, Y.; El-Kabbani, O.; Kuwata, K.; Hara, A.; Kitade, Y.; Toyooka, N.
    Bioorg. Med. Chem., 2013, 21, 6378-6384.
  3. Synthesis and Biological Evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-L-fucosidases.
    Kato, A.; Okaki, T.; Ifuku, S.; Sato, K.; Hirokami, Y.; Iwaki, R.; Kamori, A.; Nakazawa, S.; Adachi, I.; Kirira, P.G.; Onomura, O.; Minato, D.; Sugimoto, K.; Matsuya, Y.; Toyaoka, N.
    Bioorg. Med. Chem., 2013, 21, 6565-6573.
  4. Synthesis and Antitumor Activity of des-AB Analogue of Steroidal Saponin OSW-1.
    Minato, D.; Li, B.; Zhou, D.; Shigeta, Y.; Toyooka, N.; Sakurai, H.; Sugimoto, K.; Matsuya, Y.
    Tetrahedron 2013, 69, 8019-8024.
  5. Search for a Novel SIRT1 Activator: Structural Modification of SRT1720 and Biological Evaluation.
    Matsuya, Y.; Kobayashi, Y.; Uchida, S.; Itoh, Y.; Sawada, H.; Suzuki, T.; Miyata, N.; Sugimoto, K.; Toyooka, N.
    Bioorg. Med. Chem. Lett. 2013, 23, 4907-4901.
  6. Structure-activity-relationship Studies on Dihydrofuran-fused Perhydrophenanthrenes as an Anti-Alzheimer's Disease Agent.
    Sugimoto, K.; Tamura, K.; Tohda, C.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Bioorg. Med. Chem., 2013, 21, 4459-4471.
  7. Protecting-Group-Free Total Synthesis of (—)-Rhazinilam and (—)-Rhazinicine using a Gold-Catalyzed Cascade Cyclization.
    Sugimoto, K.; Toyoshima, K.; Nonaka, S.; Kotaki, K.; Ueda, H.; Tokuyama, H.
    Angew. Chem. Int. Ed. 2013, 52, 7168-7171. (Highlighted in Synfacts 2013)
  8. Enantiocontrolled Total Synthesis of (—)-Mersicarpine.
    Iwama, Y.; Okano, K.; Sugimoto, K.; Tokuyama, H.
    Chem. Eur. J. 2013, 19, 9325-9334.
  9. Synthesis of 6-Trimethylsilyl-α-pyrone from 2,6-Bis(trimethylsilyl)pyran via Mild Aerobic Oxidation.
    Zhou, D.; Matsuya, Y.
    Chin. J. Org. Chem. 2013, 33, 375-377.
  10. Stereoselective Total Synthesis of (—)-Batzellasides A, B, and C.
    Okaki, T.; Fujimura, R.; Sekiguchi, M.; Zhou, D.; Sugimoto, K.; Minato, D.; Matsuya, Y.; Kato, A.; Adachi, I.; Tezuka, Y.; Saporito, R. A.; Toyooka, N.
    Eur. J. Org. Chem. 2013, 2841-2848.
  11. Synthesis and Antitumor Evaluation of Arctigenin Derivatives Based on Antiausterity Strategy.
    Kudou, N.; Taniguchi, A.; Sugimoto, K.; Matsuya, Y.; Kawasaki, M.; Toyooka, N.; Miyoshi, C.; Suresh, A.; Dya, F. D.; Esumi, H.; Kadota, S.; Tezuka, Y.
    Eur. J. Med. Chem. 2013, 60, 76-88.
  12. The Sirt1 Activator SRT1720 Suppresses Inflammation in an OVA-induced Mouse Model of Asthma.
    Ichikawa, T.; Hayashi, R.; Suzuki, K.; Imanishi, S.; Kambara, K.; Okazawa, S.; Inomata, M.; Yamada, T.; Yamazaki, Y.; Kanatani, Y.; Miwa, T.; Matsui, S.; Usui, I.; Urakaze, M.; Matsuya, Y.; Sasahara, M.; Tobe, K.
    Respirology 2013, 18, 332-339.
  13. Rational Design and Synthesis of 4-Substituted 2-Pyridin-2-ylamides with Inhibitory Effects on SH2 Domain-containing Inositol 5'-Phosphatase 2 (SHIP2).
    Ichihara, Y.; Fujimura, R.; Tsuneki, H.; Wada, T.; Okamoto, K.; Gouda, H.; Hirono, S.; Sugimoto, K.; Matsuya, Y.; Sasaoka, T.; Toyooka, N.
    Eur. J. Med. Chem. 2013, 62, 649-668.
  14. A Novel Compound, Denosomin Ameliorates Spinal Cord Injury via Axonal Growth Associated with Astrocyte-secreted Vimentin.
    Teshigawara, K.; Kuboyama, T.; Shigyo, M.; Nagata, A.; Sugimoto, K.; Matsuya, Y.; Tohda, C.
    Br. J. Pharmacol. 2013, 168, 903-919.
  15. New Aminobenzopyranoxanthene‐Based Colorimetric Sensor for Copper(II) Ions with Dual‐Color Signal Detection System
    Shirasaki, Y.; Kamino, S.; Tanioka, M.; Watanabe, K.; Takeuchi, Y.; Komeda, S,; Enomoto S.
    Chem. Asian J. 2013, 8, 2609-2613 (DOI:10.1002/asia.201300515)

2012

  1. Novel Sequential 1,4-Brook Rearrangement—Wittig Reaction: New One-pot Approach for Silyl Dienol Ethers.
    Matsuya, Y.; Koiwai, A.; Minato, D.; Sugimoto, K.; Toyooka, N.
    Tetrahedron Lett. 2012, 53, 5955-5957.
  2. Efficient Approach to 1,2-Diazepines via Formal Diazomethylene Insertion into the C—C Bond of Cyclobutenones.
    Sugimoto, K.; Hayashi, R.; Nemoto, H.; Toyooka, N.; Matsuya, Y.
    Org. Lett. 2012, 14, 3510-3513.
  3. Ring-Expansion Reaction of Oximes with Aluminum Reductants.
    Cho, H.; Iwama, Y.; Mitsuhashi, N.; Sugimoto, K.; Okano, K.; Tokuyama, H.
    Molecules, 2012, 17, 7348-7355.
  4. Synthesis and biological evaluation of optically active Ki16425.
    Sato, T.; Sugimoto, K.; Inoue, A.; Okudaira, S.; Aoki, J.; Tokuyama, H.
    Bioorg. Med. Chem. Lett. 2012, 22, 4323-4326.
  5. SRT1720, a SIRT1 Activator, Promotes Tumor Cell Migration, and Lung Metastasis of Breast Cancer in Mice.
    Suzuki, K.; Hayashi, R.; Ichikawa, T.; Imanishi, S.; Yamada, T.; Inomata, M.; Miwa, T.; Matsui, S.; Usui, I.; Urakaze, M.; Matsuya, Y.; Ogawa, H.; Sakurai, H.; Saiki, I.; Tobe, K.
    Oncol. Rep. 2012, 27, 1726-1732.
  6. Synthesis and Biological Evaluation of Pyrethroid Insecticide-derivatives as a Chemical Inducer for Bdnf mRNA Expression in Neurons.
    Matsuya, Y. ; Ihara, D. Fukuchi, M.; Honma, D.; Itoh, K.; Tabuchi, A.; Nemoto, H.; Tsuda, M.
    Bioorg. Med. Chem. 2012, 20, 2564-2571.
  7. Concise Total Synthesis of (—)-Mersicarpine
    Iwama, Y.; Okano, K.; Sugimoto, K.; Tokuyama, H.
    Org. Lett. 2012, 14, 2320-2322. (Highlighted in Synfacts 2012)ジ
  8. Synthesis of Dihydrofuran-fused Perhydrophenanthrenes Having a Phenolic Hydroxyl Group as a Novel Anti-Alzheimer's Disease Agent.
    Sugimoto, K.; Tamura, K.; Ohta, N.; Tohda, C.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Bioorg. Med. Chem. Lett. 2012, 22, 449-452.
  9. Design, Synthesis, and Biological Evaluation of Novel (1-Thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic Acids as Selective Inhibitors for AKR1B1.
    Minehira, D.; Takeda, D.; Urata, H.; Kato, A.; Adachi, I.; Wang, X.; Matsuya, Y.; Sugimoto, K.; Takemura, M.; Endo, S.; Matsunaga, T.; Hara, A.; Koseki, J.; Narukawa, K.; Hirono, S.; Toyooka, N.
    Bioorg. Med. Chem. 2012, 20, 356-367.
  10. Induction of Prolonged, Continuous Slow-wave Sleep by Blocking Cerebral H1 Histamine Receptors in Rats.
    Ikeda-Sagara, M.; Ozaki, T.; Shahid, M.; Morioka, E.; Wada, K.; Honda, K.; Hori, A.; Matsuya, Y.; Toyooka, N.; Ikeda, M.
    Br. J. Pharmacol. 2012, 165, 167-182.

2011

  1. Dihydroazamacrosphelides: Syntheses and Apoptosis Inducing Activities.
    Sugimoto, K.; Kobayashi, Y.; Kondo, T.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Heterocycles 2011, 83, 2823-2835.
  2. Synthesis of Aza-analogues of Macrosphelides via RCM Strategy and Their Biological Evaluation.
    Sugimoto, K.; Kobayashi, Y.; Hori, A.; Kondo, T.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Tetrahedron 2011, 67, 7681-7685.
  3. Sominone Improves Memory Impairments and Increases Axonal Density in Alzheimer's Disease Model Mice, 5XFAD.
    Joyashiki, E.; Matsuya, Y.; Tohda, C.
    Int. J. Neurosci. 2011, 121, 181-190.
  4. Synthetic Studies toward Haouamine B: Construction of Indenotetrahydropyridone Skeleton.
    Okuyama, K.; Momoi, Y.; Sugimoto, K.; Okano, K.; Tokuyama, H.
    Synlett 2011, 73-76.
  5. Regiospecific Rearrangement of Hydroxylamines to Secondary Amines using Diisobutylaluminum Hydride.
    Cho, H.; Sugimoto, K.; Iwama, Y.; Mitsuhashi, N.; Okano, K.; Tokuyama, H.
    Heterocycles 2011, 82, 1633-1644.

2010

  1. Lipase-mediated Preparation of Optically Active Isomers of Rosaphen.
    Kawasaki, M.; Toyooka, N.; Saka, T.; Goto, M.; Matsuya, Y.; Kometani, T.
    J. Mol. Catal. B: Enzym. 2010, 67, 135-142.
  2. Synthesis and Anti-Influenza Virus Activity of Dihydrofuran-Fused Perhydrophenanthrenes with a Benzyloxy-Type Side-Chain.
    Matsuya, Y.; Suzuki, N.; Kobayashi, S.; Miyahara, T.; Ochiai, H.; Nemoto, H.
    Bioorg. Med. Chem. 2010, 18, 1477-1481.
  3. Synthesis of Macrosphelides Containing a Heterocyclic Side Chain as a Novel Apoptosis Inducer.
    Matsuya, Y.; Hori, A.; Kawamura, T.; Emam, H. F.; Ahmed, K.; Yu, D.-Y.; Kondo, T.; Toyooka, N.; Nemoto, H.
    Heterocycles 2010, 80, 579-591.
  4. Regioselective Synthesis of Heterocycles containing Nitrogen Neighboring an Aromatic Ring by the Reductive Ring Expansion using Diisobutylaluminum Hydride (DIBALH) and Studies on the Reaction Mechanism.
    Cho, H.; Iwama, Y.; Sugimoto, K.; Mori, S.; Tokuyama, H.
    J. Org. Chem. 2010, 75, 627-636.

2009

  1. Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
    Yamazaki, Y.; Usui, I.; Kanatani, Y.; Matsuya, Y.; Tsuneyama, K.; Fujisaka, S.; Bukhari, A.; Suzuki, H.; Senda, S.; Imanishi, S.; Hirata, K.; Ishiki, M.; Hayashi, R.; Urakaze, M.; Nemoto, H.; Kobayashi, M.; Tobe, K.
    Am. J. Physiol. Endocrinol. Metab. 2009, 297, E1179-E1186.
  2. Synthesis of Sominone and Its Derivatives Based on an RCM Strategy: Discovery of A Novel Anti-Alzheimer's Disease Medicine Candidate "Denosomin".
    Matsuya, Y.; Yamakawa, Y.; Tohda, C.; Teshigawara, K.; Yamada, M.; Nemoto, H.
    Org. Lett. 2009, 11, 3970-3973.
  3. Design, Synthesis, and Biological Evaluation of Artificial Macrosphelides in Search for New Apoptosis-inducing Agents.
    Matsuya, Y.; Kobayashi, Y.; Kawaguchi, T.; Hori, A.; Watanabe, Y.; Ishihara, K.; Ahmed, K.; Wei, Z.-L.; Yu, D.-Y.; Zhao, Q.-L.; Kondo, T.; Nemoto, H.
    Chem. Eur. J. 2009, 15, 5799-5813.
  4. Novel 3,4-Diazabenzotropone Compounds (2,3-Benzodiazepin-5-ones): Synthesis, Unique Reactivity, and Biological Evaluation.
    Matsuya, Y.; Katayanagi, H.; Ohdaira, T.; Wei, Z.-L.; Kondo, T.; Nemoto, H.
    Org. Lett. 2009, 11, 1361-1364.
  5. Mechanism of Apoptosis Induced by a Newly Synthesized Derivative of Macrosphelides with a Thiazole Side Chain.
    Ahmed, K.; Matsuya, Y.; Nemoto, H.; Zaidi, S. F. H.; Sugiyama, T.; Yoshihisa, Y.; Shimizu, T.; Kondo, T.
    Chem. Biol. Interact. 2009, 177, 218-226.
  6. Studies toward Intramolecular Cycloaddition of o-Quinodimethane with an Oxazole Moiety.
    Matsuya, Y.; Qin, H.; Nemoto, H.
    Heterocycles 2009, 79, 773-779.
  7. Total Synthesis of 2-Nor-macrosphelide A and B.
    Matsuya, Y.; Matsushita, T.; Sakamoto, K.; Nemoto, H.
    Heterocycles 2009, 77, 483-492.
  8. Total Synthesis of (+)-Haplophytine.
    Ueda, H.; Satoh, H.; Matsumoto, K.; Sugimoto, K.; Fukuyama, T.; Tokuyama, H.
    Angew. Chem. Int. Ed. 2009, 48, 7600-7603. (Highlighted in Synfacts 2010)
  9. Regiospecific Synthesis of Unsubsituted Basic Skeletons of Heterocycles Containing Nitrogen Neighboring an Aromatic Ring by the Reductive Ring Expansion Reaction using Diisobutylaluminum Hydride.
    Cho, H.; Iwama, Y.; Sugimoto, K.; Kwon, E.; Tokuyama, H.
    Heterocycles 2009, 78, 1183-1190.

2008

  1. Kinetically-controlled Ring-closing Metathesis: Synthesis of a Potential Scaffold for 12-Membered Salicylic Macrolides.
    Matsuya, Y.; Takayanagi, S.; Nemoto, H.
    Chem. Eur. J. 2008, 14, 5275-5281.
  2. Enhancement of Hyperthermia-induced Apoptosis by a New Synthesized Class of Benzocycloalkene Compounds.
    Yu, D.-Y.; Matsuya, Y.; Zhao, Q.-L.; Ahmed, K.; Wei, Z.-L.; Hori, T.; Nemoto, H.; Kondo, T.
    Apoptosis 2008, 13, 448-461.
  3. Three Component Coupling Reaction and Cyclization of N-Tosylimines and TMS-substituted Propiolate Mediated by DABCO.
    Matsuya, Y.; Hayashi, K.; Wada, A.; Nemoto, H.
    J. Org. Chem. 2008, 73, 1987-1990.
  4. Approach to a New Dihydrofuran-Fused Cyclic System by a Remarkable Switching of endo/exo Selectivity of a [4+2] Cycloaddition Reaction.
    Matsuya, Y.; Imamura, Y.; Miyahara, T.; Ochiai, H.; Nemoto, H.
    Eur. J. Org. Chem. 2008, 1426-1430.

2007

  1. OSW-1 Analogues: Modification of the Carbohydrate Moiety.
    Tschamber, T.; Adam, S.; Matsuya, Y.; Masuda, S.; Ohsawa, N.; Maruyama, S.; Kamoshita, K.; Nemoto, H.; Eustache, J.
    Bioorg. Med. Chem. Lett. 2007, 17, 5101-5106.
  2. Rapid and Transient Intracellular Oxidative Stress Due to Novel Macrosphelides Trigger Apoptosis via Fas/caspase-8-dependent Pathway in Human Lymphoma U937 Cells.
    Ahmed, K.; Zhao, Q.-L.; Matsuya, Y.; Yu, D.-Y.; Feril, L. B., Jr.; Nemoto, H.; Kondo, T.
    Chem. Biol. Interact. 2007, 170, 86-99.
  3. Enhancement of Macrosphelide-induced Apoptosis by Mild Hyperthermia.
    Ahmed, K.; Zhao, Q.-L.; Matsuya, Y.; Yu, D.-Y.; Salunga, T. L.; Nemoto, H.; Kondo, T.
    Int. J. Hyperthermia 2007, 23, 353-361.
  4. Enhancement of Hyperthermia-induced Apoptosis by a New Synthesized Class of Furan-fused Tetracyclic Compounds.
    Yu, D.-Y.; Matsuya, Y.; Zhao, Q.-L.; Ahmed, K.; Wei, Z.-L.; Nemoto, H.; Kondo, T.
    Apoptosis 2007, 12, 1523-1532.
  5. Synthesis and Biological Evaluation of Dihydrofuran-Fused Perhydrophenanthrenes as a New Anti-Influenza Agent Having Novel Structural Characteristic.
    Matsuya, Y.; Sasaki, K.; Ochiai, H.; Nemoto, H.
    Bioorg. Med. Chem. 2007, 15, 424-432.
  6. Synthesis of Vinyloxazolidinones by Palladium-catalyzed CO2-recycling Reaction of 4-(Benzylamino)-2-butenyl Carbonates.
    Yoshida, M.; Ohsawa, Y.; Sugimoto, K.; Tokuyama, H.; Ihara, M.
    Tetrahedron Lett. 2007, 48, 8678-8682.
  7. Palladium-catalyzed Three-component Coupling of Propargylic Oxiranes, Phenols and Carbon Dioxide.
    Yoshida, M.; Murao, T.; Sugimoto, K.; Ihara, M.
    Synlett 2007, 575-578.

2006

  1. Facile Transformation of Benzocyclobutenones into 2,3-Benzodiazepines via 4π-8π Tandem Electrocyclic Reactions Involving Net Insertion of Diazomethylene Compounds.
    Matsuya, Y.; Ohsawa, N.; Nemoto, H.
    J. Am. Chem. Soc. 2006, 128, 13072-13073.
  2. Synthesis of Macrosphelides with a Thiazole Side Chain: New Antitumor Candidates Having Apoptosis-Inducing Property.
    Matsuya, Y.; Kawaguchi, T.; Ishihara, K.; Ahmed, K.; Zhao, Q.-L.; Kondo, T.; Nemoto, H.
    Org. Lett. 2006, 8, 4609-4612.
  3. Accelerated Electrocyclic Ring-opening of Benzocyclobutenes under the Influence of a β-Silicon Atom.
    Matsuya, Y.; Ohsawa, N.; Nemoto, H.
    J. Am. Chem. Soc. 2006, 128, 412-413.
  4. Ruthenium-catalyzed Ring Expansion Reaction of 1-Acetylenylcyclobutanols with Methyl Vinyl Ketone.
    Sugimoto, K.; Yoshida, M.; Ihara, M.
    Synlett 2006, 1923-1927.

2005

  1. Novel Phorbol Esters Exert Dichotomous Effects on Inhibition of HIV-1 Infection and Activation of Latent HIV-1 Expression.
    Yu, Z.; Matsuya, Y.; Nemoto, H.; Mori, M.; Saito, H.; Yamamoto, N.
    Antiviral Chem. Chemother. 2005, 16, 303-313.
  2. A Practical Asymmetric Synthesis of trans-4,5-Benzhydrindan-1-ones as a Precursor of A-Nor B-Aromatic Steroidal Compounds.
    Matsuya, Y.; Masuda, S.; Itoh, T.; Murai, T.; Nemoto, H.
    J. Org. Chem. 2005, 70, 6898-6903.
  3. Synthesis of New Phorbol Derivatives Having Ethereal Side-chain and Evaluation of Their Anti-HIV Activity.
    Matsuya, Y.; Yu, Z.; Yamamoto, N.; Mori, M.; Saito, H.; Takeuchi, M.; Ito, M.; Nemoto, H.
    Bioorg. Med. Chem. 2005, 13, 4383-4388.
  4. A New Protocol for Consecutive α- and β-Activation of Propiolates toward Electrophiles Involving Conjugate Addition of Tertiary Amines and Intramolecular Silyl Migration.
    Matsuya, Y.; Hayashi, K.; Nemoto, H.
    Chem. Eur. J. 2005, 11, 5408-5418.
  5. Synthesis and Antitumor Activity of the Estrane Analogue of OSW-1.
    Matsuya, Y.; Masuda, S.; Ohsawa, N.; Adam, S.; Tschamber, T.; Eustache, J.; Kamoshita, K.; Sukenaga, Y.; Nemoto, H.
    Eur. J. Org. Chem. 2005, 803-808.

2004

  1. Synthesis of a New Class of Furan-fused Tetracyclic Compounds Using o-Quinodimethane Chemistry and Investigation of Their Anti-viral Activity.
    Matsuya, Y.; Sasaki, K.; Nagaoka, M.; Kakuda, H.; Toyooka, N.; Imanishi, N.; Ochiai, H.; Nemoto, H.
    J. Org. Chem. 2004, 69, 7989-7993.
  2. Synthesis and Biological Evaluation of Macrosphelide Cores.
    Ishihara, K.; Kawaguchi, T.; Matsuya, Y.; Sakurai, H.; Saiki, I.; Nemoto, H.
    Eur. J. Org. Chem. 2004, 3973-3978.
  3. Total Synthesis of Macrosphelides A, B, and E: First Application of Ring-Closing Metathesis for Macrosphelide Synthesis.
    Kawaguchi, T.; Funamori, N.; Matsuya, Y.; Nemoto, H.
    J. Org. Chem. 2004, 69, 505-509.
  4. Synthesis of New Potentially Antiviral Furan-fused Compounds by Thermolysis of Benzocyclobutene Derivatives.
    Matsuya, Y.; Qin, H.; Nagaoka, M.; Nemoto, H.
    Heterocycles 2004, 62, 207-211.
  5. Palladium-catalyzed Ring Expansion Reaction of (Z)-1-(1,3-butadienyl)cyclobutanols with Aryl Iodides. Stereospecific Synthesis of (Z)-2-(3-Aryl-1-propenyl)cyclopentanones.
    Yoshida, M.; Sugimoto, K.; Ihara, M.
    Org. Lett. 2004, 6, 1979-1982.

2003

  1. Preparation and Derivatization of the Core Compound of Macrosphelide E-G Series.
    Matsuya, Y.; Ishihara, K.; Funamori, N.; Kawaguchi, T.; Nemoto, H.
    Heterocycles 2003, 61, 59-63.
  2. New Strategy for the Total Synthesis of Macrosphelides A and B Based on Ring-Closing Metathesis.
    Matsuya, Y.; Kawaguchi, T.; Nemoto, H.
    Org. Lett. 2003, 5, 2939-2941.
  3. Synthesis of Various Macrosphelides by Oxidative Derivatization of the Macrosphelide Core.
    Matsuya, Y.; Kawaguchi, T.; Nemoto, H.
    Heterocycles 2003, 61, 39-43.
  4. Synthesis of Transient Functionalized Dienes by Electrocyclic Ring-Opening of Cyclobutene Derivatives.
    Matsuya, Y.; Sasaki, K.; Nemoto, H.
    Arkivoc 2003 (Part 8), 79-92.
  5. Total Synthesis of A-Nor B-Aromatic OSW-1 Aglycon: A Highly Effective Approach to Optically Active trans-4,5-Benzhydrindane.
    Matsuya, Y.; Itoh, T.; Nemoto, H.
    Eur. J. Org. Chem. 2003, 2221-2224.
  6. A New Efficient Synthesis of Both Enantiomers of Macrosphelide Core: A Potential Precursor for Functionalized Macrosphelides.
    Matsuya, Y.; Kawaguchi, T.; Nemoto, H.; Nozaki, H.; Hamada, H.
    Heterocycles 2003, 59, 481-484.
  7. A Novel Modified Baylis-Hillman Reaction of Propiolate.
    Matsuya, Y.; Hayashi, K.; Nemoto, H.
    J. Am. Chem. Soc. 2003, 125, 646-647.
  8. Ruthenium Catalyzed Dimerization-Ring Expansion Reaction of Acetylenylcyclobutanols.
    Yoshida, M.; Sugimoto, K.; Ihara, M
    ARKIVOC 2003, xiii, 35-44.
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