富山大学薬学部／大学院医学薬学研究部
薬品製造学研究室
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Laboratory of Synthetic and Medicinal Chemistry

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Publication List (Matsuya)

  1. Coerulein B: a water-soluble and water-compatible near-infrared photoredox catalyst
    Tanioka, M.; Oyama, M.; Nakajima, K.; Mori, M.; Harada, M.; Matsuya, Y.; Kamino, S.
    Phys. Chem. Chem. Phys. 2024, 26, 4474-4479 (doi: 10.1039/D3CP05585J).
  2. Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity
    Kohyama, A.; Shiuchi, A.; Zhou, Y.; Tanioka, M.; Sugimoto, K.: Sakurai, H.; Matsuya, Y.
    Org. Biomol. Chem. 2023, 21, 4656-4660 (doi: 10.1039/D3OB00357D).
  3. One-Pot Synthesis of Pentasubstituted Pyridines following the Gold(I)-Catalyzed Aza–Enyne Metathesis/6π-Electrocyclization–Aromatization Sequence
    Kosuge, S.; Araki, Y.; Tsuge, K.; Sugimoto, K.; Matsuya, Y.
    J. Org. Chem. 2023, 88, 6973–6986 (doi: 10.1021/acs.joc.3c00270).
  4. DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies
    Kikuchi, S.; Wada, A.; Kamihara, Y.; Okazaki, K.; Jawaid, P.; Rehman, M. U.; Kobayashi, E.; Susukida, T; Minemura, T.; Nabe, Y.; Iwao, N.; Ozawa, T.; Hatano, Y.; Yamada, M.; Kishi, H.; Matsuya, Y.; Mizuguchi, M.; Hayakawa, Y.; Dang, N. H.; Sakamoto, Y.; Morimoto, C.; Sato, T.
    Cells 2023, 12, 1100 (doi: 10.3390/cells12071100).
  5. Acceleration effect of mild organocatalytic system 2,2´-Biphenol/B(OH)3 for 2-aza-Cope rearrangement
    Sugimoto, K.; Yoshida, M.; Matsuya, Y.
    Tetrahedron Lett. 2022, 102, 153922 (doi:10.1016/j.tetlet.2022.153922).
  6. Structure-Activity Relationship and Mechanistic Study on Gugglesterone derivatives; Discovery of New Anti-pancreatic Cancer Candidate
    Kohyama, A.; Kim, M. J.; Yokoyama, R.; Sun, S.; Omar, A. M.; Phan, N. D.; Meselhy, M. R.; Tsuge, K.; Awale, S.; Matsuya, Y.
    Bioorg. Med. Chem. 2022, 54, 116563 (doi: 10.1016/j.bmc.2021.116563).
  7. Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008
    Fujii, T.; Sugimoto, K.; Noda, T.; Shimizu, T.; Matsuya, Y.; Sakai, H.
    Biochem. Biophys. Res. Commun. 2021, 567, 177-182 (doi: org/10.1016/j.bbrc.2021.06.056)
  8. Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells
    Abdellatef, A. A.; Zhou, Y.; Yamada, A.; Elmekkawy, S. A.; Kohyama, A.; Yokoyama, S.; Meselhy, M. R.; Matsuya, Y.; Sakurai, H.; Hayakawa, Y.
    Biomed. Pharmacother. 2021, 140, 111737 (doi: 10.1016/j.biopha.2021.111737)
  9. Au(I) Catalyzed Synthesis of Densely Substituted Pyrazolines and Dihydropyridines via Sequential Aza-Enyne Metathesis/6π-Electrocyclization
    Sugimoto, K.; Kosuge, S.; Sugita, T.; Miura, Y.; Tsuge, K.; Matsuya, Y.
    Org. Lett. 2021, 23, 3981-3985 (doi: 10.1021/acs.orglett.1c01171)
  10. Divinylcarbinol Desymmetrization Strategy: A Concise and Reliable Approach to Chiral Hydroxylated Fatty Acid Derivatives.
    Sugimoto, K.; Kobayashi, A.; Kohyama, A.; Sakai, H.; Matsuya, Y.
    J. Org. Chem. 2021, 86, 3970-3980 (doi: org/10.1021/acs.joc.0c02821)
  11. De Novo Approach to Izidines via a Gold-Catalyzed Hydroamination–N-acyliminium Ion Cyclization of Acyclic Ynamides.
    Sugimoto, K.; Mizuno, S.; Shirato, M.; Tanabe, K.; Matsuya, Y.
    Heterocycles 2020, 103, 526-543. doi: 10.3987/COM-20-S(K)38
  12. Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells.
    Kohyama, A.; Yokoyama, R.; Dibwe, D. F.; El-Mekkawy, S.; Meselhy, M. R.; Awale, S.; Matsuya, Y.
    Bioorg. Med. Chem. Lett. 2020, 30, 126964 (doi: 10.1016/j.bmcl.2020.126964)
  13. 2,2 -Biphenol/B(OH)3 Catalyst System for Nazarov Cyclization.
    Sugimoto, K.; Oshiro, M.; Hada, R.; Matsuya, Y.
    Chem. Pharm. Bull. 2019, 67, 1019-1022.
  14. An Improved Synthesis of a Salicylated Divinylcarbinol Derivative as a Part of Salicylic Macrolides.
    Kohyama, A.; Oguma, Y.; Yamagishi, T.; Sugimoto, K.; Matsuya, Y.
    Heterocycles, 2020, 100, 137-140, doi:10.3987/COM-19-14120.
  15. Facile o-Quinodimethane Formation from Benzocyclobutenes Triggered by Staudinger Reaction at Ambient Temperature.
    Kohyama, A.; Koresawa, E.; Tsuge, K.; Matsuya, Y.
    Chem. Comm. 2019, 55, 6205-6208.
  16. Recent Application of ortho-Quinodimethane Chemistry for Synthesis of Heterocyclic Compounds.
    Matsuya, Y.
    Heterocycles, 2019, 98, 621-635. doi:10.3987/REV-19-908.
  17. Synthetic Studies on Pyrroloindolizidine Skeleton Based on Gold—Catalyzed Hydroamination—Enamine Cyclization—Ring—Closing Metathesis Strategy.
    Sugimoto, K.; Matsuo, N.; Tominaga, D.; Matsuya, Y.
    Heterocycles 2019, 99, 875-890. (DOI:10.3987/COM-18-S(F)56).
  18. Acetic Acid, 2-[(1,1-Dimethylethyl)dimethylsilyl]-2-oxo-, Phenylmethyl ester.
    Sugimoto, K.; Matsuya, Y.
    eEROS, 2018. doi.org/10.1002/047084289X.rn02232.
  19. Free Radical Generation by Non-equilibrium Atmospheric Pressure Plasma in Alcohol-water Mixtures: An EPR-spin Trapping Study.
    Uchiyama, H.; Ishikawa, K.; Zhao, Q.-L.; Andocs, G.; Nojima, N.; Takeda, K.; Krishna, M. ; Ishijima, T.; Matsuya, Y.; Hori, M.; Noguchi, K.; Kondo, T.
    J. Phys. D: Appl. Phys., 2018, 51, 9, 095202.
  20. Stereoselective Synthesis of a Pivotal Chiral Intermediate for Natural Salicylic Macrolides.
    Oguma, Y.; Yamamoto, N.; Sugimoto, K.; Matsuya, Y.
    Heterocycles, 2018, 97, 283-291.
  21. Recent Applications of Gold-catalyzed Cascade Reactions in Total Synthesis of Natural Product.
    Sugimoto, K.; Matsuya, Y.
    Tetrahedron Lett. 2017, 58, 4420-4426.
    (Most Downloaded Tetrahedron Letters Articles. 2018. 01)
  22. Synthetic Study towards Construction of Potential Scaffold of Antitumor Agents Andrastins.
    Yin, S.; Sugimoto, K.; Nemoto, H.; Matsuya, Y.
    Heterocycles, 2017, 95, 187-199.
  23. Construction of cis-Fused Hydrindane Skeleton with a Lactone Tether Utilizing Intramolecular Diels-Alder Reaction.
    Yin, S.; Takai, K.; Minato, D.; Sugimoto, K.; Ohtsu, H.; Tsuge, K.; Matsuya, Y.
    Heterocycles, 2016, 93, 783-791.
  24. A Macrosphelide as the Unexpected Product of a Pleurotus Ostreatus Strain-mediated Biotransformation of Halolactones containing the gem-dimethylcyclohexane Ring. Part 1
    Wińska, K.; Mączka, W.; Grabarczyk, M.; Sugimoto, K.; Matsuya, Y.; Szumny, A.; Aniol, M.
    Molecules, 2016, 21, 859.
  25. A Novel Method for Determining Peroxisomal Fatty Acid β-Oxidation.
    Morita, M.; Matsumoto, S.; Okazaki, A.; Tomita, K.; Watanabe, S.; Kawaguchi, K.; Minato, D.; Matsuya, Y.; Shimozawa, N.; Imanaka, T.
    J. Inherit. Metab. Dis., 2016, 39, 725-731.
  26. Highly Efficient Access to Both Geometric Isomers of Silyl Enol Ethers: Sequential 1,2-Brook/Wittig Reactions.
    Matsuya, Y.; Wada, K.; Minato, D.; Sugimoto, K.
    Angew. Chem. Int. Ed. 2016, 55, 10079-10082.
  27. Synthesis of Substituted Pyrrolo[2,1-a]isoquinolines by Gold-catalyzed Domino Cyclization of Alkynyl Iminoesters.
    Sugimoto, K.; Hoshiba, Y.; Tsuge, K.; Matsuya, Y.
    Synthesis, 2016, 48, 1855-1864.
  28. In vitro and in vivo Antiherpetic Effects of (1R,2R)-1-(5'-methylful-3'-yl)propane-1,2,3-triol.
    Sasaki, K.; Hayashi, K.; Matsuya, Y.; Sugimoto, K.; Lee, J.-B.; Kurosaki, F.; Hayashi, T.
    J. Nat. Med. 2016, 70, 217-224.
  29. Synthesis of Denosomin&mdashVitamin D3 Hybrids and Evaluation of their Anti-Alzheimer's Disease Activities.
    Sugimoto, K.; Yajima, H.; Hayashi, Y.; Minato, D.; Terasaki, S.; Tohda, C.; Matsuya, Y.
    Org. Lett. 2015, 17, 5910-5913.
  30. Three-Component Domino Process for Pyrrolizine Skeleton via [3+2]-Cycloaddition—Enamine Cyclization Triggered by Gold Catalyst.
    Sugimoto, K.; Yamamoto, N.; Tominaga, D.; Matsuya, Y.
    Org. Lett. 2015, 17, 1320-1323.
  31. Preparation of (2R,4S)/(2S,4S)-4-Hydroxypipecolinic Acid Derivatives from L-(—)-Malic Acid.
    Yin, S.; Taneda, H.; Li, B.; Zhou, D.; Minato, D.; Sugimoto, K.; Matsuya, Y.
    Heterocycles 2015, 90, 928-938.
  32. Synthesis and Evaluations of GLP-1 Secretion and Anti-Diabetic Effect in KKAy Mice of New Tricyclic Compounds.
    Minehira, D.; Takeda, D.; Miyawaki, S.; Kato, A.; Adachi, I.; Miyazaki, A.; Miyatake, R.; Umezaki, M.; Miura, K.; Kitahara, Y.; Sugimoto, K.; Matsuya, Y.; Toyooka N.
    Heterocycles 2015, 90, 372-404.
  33. Stereoselective Approach to Potential Scaffold of A-nor B-aromatic OSW-1 analogues via [4+2] Cycloaddition of o-Quinodimethane
    Li, B.; Masuda, S.; Minato, D.; Zhou, D.; Sugimoto, K.; Nemoto, H.; Matsuya, Y.
    Tetrahedron 2014, 70, 3981-3987.
  34. Synthesis of 8-Amino-(dihydrofuran-fused perhydrophenanthrene) via Copper-Mediated Amination Reaction.
    Sugimoto, K.; Tamura, K.; Toyooka, N.; Matsuya, Y.
    Heterocycles 2014, 88, 755-763 (Victor Snieckus's Special Issue).
  35. Synthesis of Long-chain Fatty Acid Derivatives as a Novel Anti-Alzheimer's Agent
    Zhang, H-Y.; Yamakawa, Y.; Matsuya, Y.; Toyooka, N.; Tohda, C.; Awale, S.; Li, F.; Kadota, S.; Tezuka, Y.
    Bioorg. Med. Chem. Lett. 2014, 24, 604-608.
  36. Synthesis of Phenylalkyl-substituted Polyhydroxypiperidines as Potent Inhibitors for α-L-fucosidase.
    Saka, T.; Okaki, T.; Ifuku, S.; Yamashita, Y.; Sato, K.; Miyawaki, S.; Kamori, A.; Kato, A.; Adachi, I.; Tezuka, Y.; Kiria, P. G.; Onomura, O.; Minato, D.; Sugimoto, K.; Matsuya, Y.; Toyooka N.
    Tetrahedron 2013, 69, 10653-10661.
  37. Synthesis and Structure-activity Relationship of 2-Phenyliminochromene Derivatives as Inhibitors for Aldo-keto Reductase (AKR) 1B10.
    Endo, S.; Hu, D.; Suyama, M.; Matsunaga, T.; Sugimoto, K.; Matsuya, Y.; El-Kabbani, O.; Kuwata, K.; Hara, A.; Kitade, Y.; Toyooka, N.
    Bioorg. Med. Chem., 2013, 21, 6378-6384.
  38. Synthesis and Biological Evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-L-fucosidases.
    Kato, A.; Okaki, T.; Ifuku, S.; Sato, K.; Hirokami, Y.; Iwaki, R.; Kamori, A.; Nakazawa, S.; Adachi, I.; Kirira, P.G.; Onomura, O.; Minato, D.; Sugimoto, K.; Matsuya, Y.; Toyaoka, N.
    Bioorg. Med. Chem., 2013, 21, 6565-6573.
  39. Synthesis and Antitumor Activity of des-AB Analogue of Steroidal Saponin OSW-1.
    Minato, D.; Li, B.; Zhou, D.; Shigeta, Y.; Toyooka, N.; Sakurai, H.; Sugimoto, K.; Matsuya, Y.
    Tetrahedron 2013, 69, 8019-8024.
  40. Search for a Novel SIRT1 Activator: Structural Modification of SRT1720 and Biological Evaluation.
    Matsuya, Y.; Kobayashi, Y.; Uchida, S.; Itoh, Y.; Sawada, H.; Suzuki, T.; Miyata, N.; Sugimoto, K.; Toyooka, N.
    Bioorg. Med. Chem. Lett. 2013, 23, 4907-4901.
  41. Structure-activity-relationship Studies on Dihydrofuran-fused Perhydrophenanthrenes as an Anti-Alzheimer's Disease Agent.
    Sugimoto, K.; Tamura, K.; Tohda, C.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Bioorg. Med. Chem., 2013, 21, 4459-4471.
  42. Synthesis of 6-Trimethylsilyl-α-pyrone from 2,6-Bis(trimethylsilyl)pyran via Mild Aerobic Oxidation.
    Zhou, D.; Matsuya, Y.
    Chin. J. Org. Chem. 2013, 33, 375-377.
  43. Stereoselective Total Synthesis of (—)-Batzellasides A, B, and C.
    Okaki, T.; Fujimura, R.; Sekiguchi, M.; Zhou, D.; Sugimoto, K.; Minato, D.; Matsuya, Y.; Kato, A.; Adachi, I.; Tezuka, Y.; Saporito, R. A.; Toyooka, N.
    Eur. J. Org. Chem. 2013, 2841-2848.
  44. Synthesis and Antitumor Evaluation of Arctigenin Derivatives Based on Antiausterity Strategy.
    Kudou, N.; Taniguchi, A.; Sugimoto, K.; Matsuya, Y.; Kawasaki, M.; Toyooka, N.; Miyoshi, C.; Suresh, A.; Dya, F. D.; Esumi, H.; Kadota, S.; Tezuka, Y.
    Eur. J. Med. Chem. 2013, 60, 76-88.
  45. The Sirt1 Activator SRT1720 Suppresses Inflammation in an OVA-induced Mouse Model of Asthma.
    Ichikawa, T.; Hayashi, R.; Suzuki, K.; Imanishi, S.; Kambara, K.; Okazawa, S.; Inomata, M.; Yamada, T.; Yamazaki, Y.; Kanatani, Y.; Miwa, T.; Matsui, S.; Usui, I.; Urakaze, M.; Matsuya, Y.; Sasahara, M.; Tobe, K.
    Respirology 2013, 18, 332-339.
  46. Rational Design and Synthesis of 4-Substituted 2-Pyridin-2-ylamides with Inhibitory Effects on SH2 Domain-containing Inositol 5'-Phosphatase 2 (SHIP2).
    Ichihara, Y.; Fujimura, R.; Tsuneki, H.; Wada, T.; Okamoto, K.; Gouda, H.; Hirono, S.; Sugimoto, K.; Matsuya, Y.; Sasaoka, T.; Toyooka, N.
    Eur. J. Med. Chem. 2013, 62, 649-668.
  47. A Novel Compound, Denosomin Ameliorates Spinal Cord Injury via Axonal Growth Associated with Astrocyte-secreted Vimentin.
    Teshigawara, K.; Kuboyama, T.; Shigyo, M.; Nagata, A.; Sugimoto, K.; Matsuya, Y.; Tohda, C.
    Br. J. Pharmacol. 2013, 168, 903-919.
  48. Novel Sequential 1,4-Brook Rearrangement—Wittig Reaction: New One-pot Approach for Silyl Dienol Ethers.
    Matsuya, Y.; Koiwai, A.; Minato, D.; Sugimoto, K.; Toyooka, N.
    Tetrahedron Lett. 2012, 53, 5955-5957.
  49. Efficient Approach to 1,2-Diazepines via Formal Diazomethylene Insertion into the C—C Bond of Cyclobutenones.
    Sugimoto, K.; Hayashi, R.; Nemoto, H.; Toyooka, N.; Matsuya, Y.
    Org. Lett. 2012, 14, 3510-3513.
  50. SRT1720, a SIRT1 Activator, Promotes Tumor Cell Migration, and Lung Metastasis of Breast Cancer in Mice.
    Suzuki, K.; Hayashi, R.; Ichikawa, T.; Imanishi, S.; Yamada, T.; Inomata, M.; Miwa, T.; Matsui, S.; Usui, I.; Urakaze, M.; Matsuya, Y.; Ogawa, H.; Sakurai, H.; Saiki, I.; Tobe, K.
    Oncol. Rep. 2012, 27, 1726-1732.
  51. Synthesis and Biological Evaluation of Pyrethroid Insecticide-derivatives as a Chemical Inducer for Bdnf mRNA Expression in Neurons.
    Matsuya, Y. ; Ihara, D. Fukuchi, M.; Honma, D.; Itoh, K.; Tabuchi, A.; Nemoto, H.; Tsuda, M.
    Bioorg. Med. Chem. 2012, 20, 2564-2571.
  52. Synthesis of Dihydrofuran-fused Perhydrophenanthrenes Having a Phenolic Hydroxyl Group as a Novel Anti-Alzheimer's Disease Agent.
    Sugimoto, K.; Tamura, K.; Ohta, N.; Tohda, C.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Bioorg. Med. Chem. Lett. 2012, 22, 449-452.
  53. Design, Synthesis, and Biological Evaluation of Novel (1-Thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic Acids as Selective Inhibitors for AKR1B1.
    Minehira, D.; Takeda, D.; Urata, H.; Kato, A.; Adachi, I.; Wang, X.; Matsuya, Y.; Sugimoto, K.; Takemura, M.; Endo, S.; Matsunaga, T.; Hara, A.; Koseki, J.; Narukawa, K.; Hirono, S.; Toyooka, N.
    Bioorg. Med. Chem. 2012, 20, 356-367.
  54. Induction of Prolonged, Continuous Slow-wave Sleep by Blocking Cerebral H1 Histamine Receptors in Rats.
    Ikeda-Sagara, M.; Ozaki, T.; Shahid, M.; Morioka, E.; Wada, K.; Honda, K.; Hori, A.; Matsuya, Y.; Toyooka, N.; Ikeda, M.
    Br. J. Pharmacol. 2012, 165, 167-182.
  55. Dihydroazamacrosphelides: Syntheses and Apoptosis Inducing Activities.
    Sugimoto, K.; Kobayashi, Y.; Kondo, T.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Heterocycles 2011, 83, 2823-2835.
  56. Synthesis of Aza-analogues of Macrosphelides via RCM Strategy and Their Biological Evaluation.
    Sugimoto, K.; Kobayashi, Y.; Hori, A.; Kondo, T.; Toyooka, N.; Nemoto, H.; Matsuya, Y.
    Tetrahedron 2011, 67, 7681-7685.
  57. Sominone Improves Memory Impairments and Increases Axonal Density in Alzheimer's Disease Model Mice, 5XFAD.
    Joyashiki, E.; Matsuya, Y.; Tohda, C.
    Int. J. Neurosci. 2011, 121, 181-190.
  58. Lipase-mediated Preparation of Optically Active Isomers of Rosaphen.
    Kawasaki, M.; Toyooka, N.; Saka, T.; Goto, M.; Matsuya, Y.; Kometani, T.
    J. Mol. Catal. B: Enzym. 2010, 67, 135-142.
  59. Synthesis and Anti-Influenza Virus Activity of Dihydrofuran-Fused Perhydrophenanthrenes with a Benzyloxy-Type Side-Chain.
    Matsuya, Y.; Suzuki, N.; Kobayashi, S.; Miyahara, T.; Ochiai, H.; Nemoto, H.
    Bioorg. Med. Chem. 2010, 18, 1477-1481.
  60. Synthesis of Macrosphelides Containing a Heterocyclic Side Chain as a Novel Apoptosis Inducer.
    Matsuya, Y.; Hori, A.; Kawamura, T.; Emam, H. F.; Ahmed, K.; Yu, D.-Y.; Kondo, T.; Toyooka, N.; Nemoto, H.
    Heterocycles 2010, 80, 579-591.
  61. Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
    Yamazaki, Y.; Usui, I.; Kanatani, Y.; Matsuya, Y.; Tsuneyama, K.; Fujisaka, S.; Bukhari, A.; Suzuki, H.; Senda, S.; Imanishi, S.; Hirata, K.; Ishiki, M.; Hayashi, R.; Urakaze, M.; Nemoto, H.; Kobayashi, M.; Tobe, K.
    Am. J. Physiol. Endocrinol. Metab. 2009, 297, E1179-E1186.
  62. Synthesis of Sominone and Its Derivatives Based on an RCM Strategy: Discovery of A Novel Anti-Alzheimer's Disease Medicine Candidate "Denosomin".
    Matsuya, Y.; Yamakawa, Y.; Tohda, C.; Teshigawara, K.; Yamada, M.; Nemoto, H.
    Org. Lett. 2009, 11, 3970-3973.
  63. Design, Synthesis, and Biological Evaluation of Artificial Macrosphelides in Search for New Apoptosis-inducing Agents.
    Matsuya, Y.; Kobayashi, Y.; Kawaguchi, T.; Hori, A.; Watanabe, Y.; Ishihara, K.; Ahmed, K.; Wei, Z.-L.; Yu, D.-Y.; Zhao, Q.-L.; Kondo, T.; Nemoto, H.
    Chem. Eur. J. 2009, 15, 5799-5813.
  64. Novel 3,4-Diazabenzotropone Compounds (2,3-Benzodiazepin-5-ones): Synthesis, Unique Reactivity, and Biological Evaluation.
    Matsuya, Y.; Katayanagi, H.; Ohdaira, T.; Wei, Z.-L.; Kondo, T.; Nemoto, H.
    Org. Lett. 2009, 11, 1361-1364.
  65. Mechanism of Apoptosis Induced by a Newly Synthesized Derivative of Macrosphelides with a Thiazole Side Chain.
    Ahmed, K.; Matsuya, Y.; Nemoto, H.; Zaidi, S. F. H.; Sugiyama, T.; Yoshihisa, Y.; Shimizu, T.; Kondo, T.
    Chem. Biol. Interact. 2009, 177, 218-226.
  66. Studies toward Intramolecular Cycloaddition of o-Quinodimethane with an Oxazole Moiety.
    Matsuya, Y.; Qin, H.; Nemoto, H.
    Heterocycles 2009, 79, 773-779.
  67. Total Synthesis of 2-Nor-macrosphelide A and B.
    Matsuya, Y.; Matsushita, T.; Sakamoto, K.; Nemoto, H.
    Heterocycles 2009, 77, 483-492.
  68. Kinetically-controlled Ring-closing Metathesis: Synthesis of a Potential Scaffold for 12-Membered Salicylic Macrolides.
    Matsuya, Y.; Takayanagi, S.; Nemoto, H.
    Chem. Eur. J. 2008, 14, 5275-5281.
  69. Enhancement of Hyperthermia-induced Apoptosis by a New Synthesized Class of Benzocycloalkene Compounds.
    Yu, D.-Y.; Matsuya, Y.; Zhao, Q.-L.; Ahmed, K.; Wei, Z.-L.; Hori, T.; Nemoto, H.; Kondo, T.
    Apoptosis 2008, 13, 448-461.
  70. Three Component Coupling Reaction and Cyclization of N-Tosylimines and TMS-substituted Propiolate Mediated by DABCO.
    Matsuya, Y.; Hayashi, K.; Wada, A.; Nemoto, H.
    J. Org. Chem. 2008, 73, 1987-1990.
  71. Approach to a New Dihydrofuran-Fused Cyclic System by a Remarkable Switching of endo/exo Selectivity of a [4+2] Cycloaddition Reaction.
    Matsuya, Y.; Imamura, Y.; Miyahara, T.; Ochiai, H.; Nemoto, H.
    Eur. J. Org. Chem. 2008, 1426-1430.
  72. OSW-1 Analogues: Modification of the Carbohydrate Moiety.
    Tschamber, T.; Adam, S.; Matsuya, Y.; Masuda, S.; Ohsawa, N.; Maruyama, S.; Kamoshita, K.; Nemoto, H.; Eustache, J.
    Bioorg. Med. Chem. Lett. 2007, 17, 5101-5106.
  73. Rapid and Transient Intracellular Oxidative Stress Due to Novel Macrosphelides Trigger Apoptosis via Fas/caspase-8-dependent Pathway in Human Lymphoma U937 Cells.
    Ahmed, K.; Zhao, Q.-L.; Matsuya, Y.; Yu, D.-Y.; Feril, L. B., Jr.; Nemoto, H.; Kondo, T.
    Chem. Biol. Interact. 2007, 170, 86-99.
  74. Enhancement of Macrosphelide-induced Apoptosis by Mild Hyperthermia.
    Ahmed, K.; Zhao, Q.-L.; Matsuya, Y.; Yu, D.-Y.; Salunga, T. L.; Nemoto, H.; Kondo, T.
    Int. J. Hyperthermia 2007, 23, 353-361.
  75. Enhancement of Hyperthermia-induced Apoptosis by a New Synthesized Class of Furan-fused Tetracyclic Compounds.
    Yu, D.-Y.; Matsuya, Y.; Zhao, Q.-L.; Ahmed, K.; Wei, Z.-L.; Nemoto, H.; Kondo, T.
    Apoptosis 2007, 12, 1523-1532.
  76. Synthesis and Biological Evaluation of Dihydrofuran-Fused Perhydrophenanthrenes as a New Anti-Influenza Agent Having Novel Structural Characteristic.
    Matsuya, Y.; Sasaki, K.; Ochiai, H.; Nemoto, H.
    Bioorg. Med. Chem. 2007, 15, 424-432.
  77. Facile Transformation of Benzocyclobutenones into 2,3-Benzodiazepines via 4π-8π Tandem Electrocyclic Reactions Involving Net Insertion of Diazomethylene Compounds.
    Matsuya, Y.; Ohsawa, N.; Nemoto, H.
    J. Am. Chem. Soc. 2006, 128, 13072-13073.
  78. Synthesis of Macrosphelides with a Thiazole Side Chain: New Antitumor Candidates Having Apoptosis-Inducing Property.
    Matsuya, Y.; Kawaguchi, T.; Ishihara, K.; Ahmed, K.; Zhao, Q.-L.; Kondo, T.; Nemoto, H.
    Org. Lett. 2006, 8, 4609-4612.
  79. Accelerated Electrocyclic Ring-opening of Benzocyclobutenes under the Influence of a β-Silicon Atom.
    Matsuya, Y.; Ohsawa, N.; Nemoto, H.
    J. Am. Chem. Soc. 2006, 128, 412-413.
  80. Novel Phorbol Esters Exert Dichotomous Effects on Inhibition of HIV-1 Infection and Activation of Latent HIV-1 Expression.
    Yu, Z.; Matsuya, Y.; Nemoto, H.; Mori, M.; Saito, H.; Yamamoto, N.
    Antiviral Chem. Chemother. 2005, 16, 303-313.
  81. A Practical Asymmetric Synthesis of trans-4,5-Benzhydrindan-1-ones as a Precursor of A-Nor B-Aromatic Steroidal Compounds.
    Matsuya, Y.; Masuda, S.; Itoh, T.; Murai, T.; Nemoto, H.
    J. Org. Chem. 2005, 70, 6898-6903.
  82. Synthesis of New Phorbol Derivatives Having Ethereal Side-chain and Evaluation of Their Anti-HIV Activity.
    Matsuya, Y.; Yu, Z.; Yamamoto, N.; Mori, M.; Saito, H.; Takeuchi, M.; Ito, M.; Nemoto, H.
    Bioorg. Med. Chem. 2005, 13, 4383-4388.
  83. A New Protocol for Consecutive α- and β-Activation of Propiolates toward Electrophiles Involving Conjugate Addition of Tertiary Amines and Intramolecular Silyl Migration.
    Matsuya, Y.; Hayashi, K.; Nemoto, H.
    Chem. Eur. J. 2005, 11, 5408-5418.
  84. Synthesis and Antitumor Activity of the Estrane Analogue of OSW-1.
    Matsuya, Y.; Masuda, S.; Ohsawa, N.; Adam, S.; Tschamber, T.; Eustache, J.; Kamoshita, K.; Sukenaga, Y.; Nemoto, H.
    Eur. J. Org. Chem. 2005, 803-808.
  85. Synthesis of a New Class of Furan-fused Tetracyclic Compounds Using o-Quinodimethane Chemistry and Investigation of Their Anti-viral Activity.
    Matsuya, Y.; Sasaki, K.; Nagaoka, M.; Kakuda, H.; Toyooka, N.; Imanishi, N.; Ochiai, H.; Nemoto, H.
    J. Org. Chem. 2004, 69, 7989-7993.
  86. Synthesis and Biological Evaluation of Macrosphelide Cores.
    Ishihara, K.; Kawaguchi, T.; Matsuya, Y.; Sakurai, H.; Saiki, I.; Nemoto, H.
    Eur. J. Org. Chem. 2004, 3973-3978.
  87. Total Synthesis of Macrosphelides A, B, and E: First Application of Ring-Closing Metathesis for Macrosphelide Synthesis.
    Kawaguchi, T.; Funamori, N.; Matsuya, Y.; Nemoto, H.
    J. Org. Chem. 2004, 69, 505-509.
  88. Synthesis of New Potentially Antiviral Furan-fused Compounds by Thermolysis of Benzocyclobutene Derivatives.
    Matsuya, Y.; Qin, H.; Nagaoka, M.; Nemoto, H.
    Heterocycles 2004, 62, 207-211.
  89. Preparation and Derivatization of the Core Compound of Macrosphelide E-G Series.
    Matsuya, Y.; Ishihara, K.; Funamori, N.; Kawaguchi, T.; Nemoto, H.
    Heterocycles 2003, 61, 59-63.
  90. New Strategy for the Total Synthesis of Macrosphelides A and B Based on Ring-Closing Metathesis.
    Matsuya, Y.; Kawaguchi, T.; Nemoto, H.
    Org. Lett. 2003, 5, 2939-2941.
  91. Synthesis of Various Macrosphelides by Oxidative Derivatization of the Macrosphelide Core.
    Matsuya, Y.; Kawaguchi, T.; Nemoto, H.
    Heterocycles 2003, 61, 39-43.
  92. Synthesis of Transient Functionalized Dienes by Electrocyclic Ring-Opening of Cyclobutene Derivatives.
    Matsuya, Y.; Sasaki, K.; Nemoto, H.
    Arkivoc 2003 (Part 8), 79-92.
  93. Total Synthesis of A-Nor B-Aromatic OSW-1 Aglycon: A Highly Effective Approach to Optically Active trans-4,5-Benzhydrindane.
    Matsuya, Y.; Itoh, T.; Nemoto, H.
    Eur. J. Org. Chem. 2003, 2221-2224.
  94. A New Efficient Synthesis of Both Enantiomers of Macrosphelide Core: A Potential Precursor for Functionalized Macrosphelides.
    Matsuya, Y.; Kawaguchi, T.; Nemoto, H.; Nozaki, H.; Hamada, H.
    Heterocycles 2003, 59, 481-484.
  95. A Novel Modified Baylis-Hillman Reaction of Propiolate.
    Matsuya, Y.; Hayashi, K.; Nemoto, H.
    J. Am. Chem. Soc. 2003, 125, 646-647.
  96. A General Method for the Asymmetric Synthesis of Both Enantiomers of 1-Substituted 1,2,3,4-Tetrahydro-β-carbolines Employing Pyroglutamic Acid Derivatives as Chiral Auxiliaries.
    Itoh, T.; Miyazaki, M.; Ikeda, S.; Nagata, K.; Yokoya, M.; Matsuya, Y.; Enomoto, Y.; Ohsawa, A.
    Tetrahedron 2003, 59, 3527-3536.
  97. A New Entry to Asymmetric Synthesis of 1-Substituted 1,2,3,4-Tetrahydro-β-carbolines Employing a Pyroglutamic Acid Derivative as a Chiral Auxiliary.
    Itoh, T.; Nagata, K.; Yokoya, M.; Miyazaki, M.; Ikeda, S.; Matsuya, Y.; Enomoto, Y.; Ohsawa, A.
    Synlett 2002, 1005-1007.
  98. Preparation of Both Enantiomers of 1-Allyl-1,2,3,4-tetrahydro-β-carboline Using Allyltin Reagents and a Chiral Auxiliary Derived from L-Proline.
    Itoh, T.; Matsuya, Y.; Enomoto, Y.; Ohsawa, A.
    Tetrahedron 2001, 57, 7277-7289.
  99. A Concise Formal Total Synthesis of Deplancheine.
    Itoh, T.; Matsuya, Y.; Enomoto, Y.; Ohsawa, A.
    Heterocycles 2001, 55, 1165-1171.
  100. A Selective Synthesis of Both Enantiomers of a 1-Allyl-β-carboline Using the Same Chiral Auxiliary Derived from L-Proline.
    Matsuya, Y.; Itoh, T.; Enomoto, Y.; Ohsawa, A.
    Heterocycles 2000, 53, 2357-2361.
  101. ARadical Scavenging by N-Aminoazaaromatics.
    Itoh, T.; Miyazaki, M.; Maeta, H.; Matsuya, Y.; Nagata, K.; Ohsawa, A.
    Bioorg. Med. Chem. 2000, 8, 1983-1989.
  102. A Novel Synthesis of Chiral 1-Allyl-1,2,3,4-tetrahydro-β-carboline Employing Allyltributyltin and Chiral Acyl Chlorides.
    Itoh, T.; Matsuya, Y.; Enomoto, Y.; Nagata, K.; Miyazaki, M.; Ohsawa, A.
    Synlett 1999, 1799-1801.
  103. One Pot Reaction of Unstable N-Acyl Quaternary Salt of Thiazoles or Imidazoles with Silyl Enol Ethers Formed in situ.
    Itoh, T.; Miyazaki, M.; Nagata, K.; Matsuya, Y.; Ohsawa, A.
    Heterocycles 1999, 50, 667-671.
  104. Reaction of Secondary and Tertiary Amines with Nitric Oxide in the Presence of Oxygen.
    Itoh, T.; Matsuya, Y.; Maeta, H.; Miyazaki, M.; Nagata, K.; Ohsawa, A.
    Chem. Pharm. Bull. 1999, 47, 819-823.
  105. Effect of Oxygen on the Reaction of Secondary Amines with Nitric Oxide.
    Itoh, T.; Matsuya, Y.; Maeta, H.; Miyazaki, M.; Nagata, K.; Ohsawa, A.
    Chem. Pharm. Bull. 1999, 47, 133-135.
  106. N-Dicyanomethylides.
    Itoh, T.; Matsuya, Y.; Nagata, K.; Miyazaki, M.; Tsutsumi, N.; Ohsawa, A.
    J. Chem. Soc., Perkin Trans. 1 1998, 1637-1641.
  107. A Mild Dehydrazination Reaction of Arylhydrazines Using Nitric Oxide in the Presence of Oxygen.
    Matsuya, Y.; Itoh, T.; Nagata, K.; Ohsawa, A.
    Tetrahedron 1997, 53, 15701-15710.
  108. A Deamination of 2-Aminothiazoles and 3-Amino-1,2,4-Triazines with Nitric Oxide.
    Itoh, T.; Matsuya, Y.; Nagata, K.; Ohsawa, A.
    Chem. Pharm. Bull. 1997, 45, 1547-1549.
  109. Reaction of Amide with Nitric Oxide (NO).
    Itoh, T.; Nagata, K.; Matsuya, Y.; Miyazaki, M.; Ohsawa, A.
    Tetrahedron Lett. 1997, 38, 5017-5020.
  110. Reaction of Arylhydrazines with Nitric Oxide in the Presence of Oxygen.
    Itoh, T.; Matsuya, Y.; Nagata, K.; Ohsawa, A.
    Tetrahedron Lett. 1997, 38, 4117-4120.
  111. Reaction of Nitric Oxide with Amines.
    Itoh, T.; Nagata, K.; Matsuya, Y.; Miyazaki, M.; Ohsawa, A.
    J. Org. Chem. 1997, 62, 3582-3585.
  112. Reductive Deamination of Aromatic Amines with Nitric Oxide (NO).
    Itoh, T.; Matsuya, Y.; Nagata, K.; Ohsawa, A.
    Tetrahedron Lett. 1996, 37, 4165-4168.
  113. A New Entry to the Synthesis of 5-Substituted 1,2,3-Triazines by Reaction with Silyl Enol Ethers and Ceric Ammonium Nitrate.
    Itoh, T.; Matsuya, Y.; Hasegawa, H.; Nagata, K.; Okada, M.; Ohsawa, A.
    J. Chem. Soc., Perkin Trans. 1 1996, 2511-2515.
  114. A Regiospecific Reaction of Pyridazines with Vicarious Nucleophilic Substitution via Their Dicyanomethylide Derivatives.
    Itoh, T.; Matsuya, Y.; Nagata, K.; Okada, M.; Ohsawa, A.
    J. Chem. Soc., Chem. Commun. 1995, 2067-2068.
  115. The Synthesis of 5-Substituted 1,2,3-Triazines with Ketene Silyl Acetals and Ceric Ammonium Nitrate.
    Itoh, T.; Matsuya, Y.; Hasegawa, H.; Nagata, K.; Okada, M.; Ohsawa, A.
    Chem. Pharm. Bull. 1995, 43, 881-883.
  116. Reaction of Six-Membered Azaaromatics with Allyltributyltin.
    Itoh, T.; Hasegawa, H.; Nagata, K.; Matsuya, Y.; Okada, M.; Ohsawa, A.
    Chem. Pharm. Bull. 1994, 42, 1768-1773.
  117. The Reaction of Diazines with Allyltributyltin via N-Alkoxycarbonyldiazinium Salts.
    Itoh, T.; Hasegawa, H.; Nagata, K.; Matsuya, Y.; Ohsawa, A.
    Heterocycles 1994, 37, 709-713.
  118. トリアジン誘導体の研究（第19報）血小板凝集抑制活性を持つ2,3-ジアリールピラジン及び2,3-ジアリールピリジン誘導体の合成.
    Konno, S.; Matsuya, Y.; Kumazawa, M.; Amano, M.; Kokubo, T.; Sagi, M.; Yamanaka, H.
    YAKUGAKU ZASSHI 1993, 113, 40-52.

Reviews and Accounts (Matsuya)

  1. つくってみたらこんなことが見えてきた　—多環式アルカロイドの不斉全合成—
    杉本健士、松谷裕二
    化学 2017, 72, 64-65.
  2. Artificial Macrosphelides as a Novel Apoptosis-inducing Compound.
    Matsuya, Y.; Nemoto, H.
    Heterocycles 2010, 81, 57-66.
  3. 分子設計によるアポトーシスを標的とした増感剤の開発
    松谷裕二、Da-Yong Yu、Kanwal Ahmed、Qing-Li Zhao、Zheng-Li Wei、根本英雄、近藤　隆
    癌の臨床 2009, 55, 231-237.
  4. 酸化ストレス修飾による温熱誘発アポトーシスの増強
    近藤　隆、小川良平、趙　慶利、藤原美定、Kanwal Ahmed、Da-Yong Yu、Zheng-Li Wei、和田重人、堀　岳史、松谷裕二、根本英雄、高崎一朗、田渕圭章
    臨床ハイパーサーミア 2007, No. 2.
  5. 分子内シリル基移動を利用した共役アルキン類の新規連続的活性化法の開発
    Matsuya, Y.
    YAKUGAKU ZASSHI 2007, 127, 1207-1213.
  6. Recent Advances in Macrosphelide Synthesis.
    Matsuya, Y.; Nemoto, H.
    Heterocycles 2005, 65, 1741-1749.
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