Research｜Toyama-Asia-Africa Pharmaceutical Network

Date：September 10（Mon）, 11（Tue）, 12（Wed）, 2018
Venue：Toyama International Conference Center

September 10 (Monday), 2018

9:25～9:30

●Opening Remarks
Chairman：Hideki Sakai（University of Toyama）

9:30～10:30

●Plenary lecture
Chair: Ken-ichi Hosoya (University of Toyama)

【PL-1】Peroxisomes: Biogenesis, function, and role in human disease: Speaker：Tsuneo Imanaka (Hiroshima International University, Japan)

10:45～12:25

●Poster Short Presentation

12:25～13:30

●Lunch Break

13:30～15:00

●Poster Session, Session 1

15:20～16:00

●Invited lectures

【Session 1】

Chair: Hideki Sakai (University of Toyama)

IL-1：A novel arylamidine antifungal agent, T-2307: Speaker：Yoshiko Fukuda (Toyama Chemical Co., Ltd.)
IL-2：The design of the drug product on oral disintegrating tablets using “HOWATT” technique: Speaker：Takahiro Kawagishi (Teika Pharmaceutical Co., Ltd.)

16:20～17:30

●Invited lectures

【Session 2】

Chair: Hiroyuki Morita (University of Toyama)

IL-3：Controllable stereoselective synthesis of (Z)- and (E) homoallylic alcohols using a palladium-catalyzed three-component reaction: Speaker：Yoshikazu Horino (University of Toyama)
IL-4：DMSO-perturbing assay for identifying promiscuous enzyme inhibitors: Speaker：Keisuke Tomohara (Kyushu University)
IL-5：Genus Caralluma: The future for drug discovery: Speaker：Essam Abdel-Sattar (Cairo University, Egypt)
IL-6：Study on the effect and mechnism of sulfated polysaccharide of Sepiella Maindroni ink on the EGFR-mediated migration and invasion of tumor cells: Speaker：Wang Fengshan (Shandong University, China)

18:00～20:00

●Banquet (Toyama International Conference Center)

September 11 (Tuesday), 2018

9:30～10:40

●Invited lectures

【Session 3】

Chair: Keisuke Tomohara (Kyushu University)

IL-7：An efficient method for the synthesis of highly substituted indoles from spiro- cyclopropanes for drug discovery: Speaker：Hisanori Nambu (University of Toyama)
IL-8：Tridental tetraarene receptor for hydroxy guests: Speaker：Hajime Abe (Himeji Dokkyo University)
IL-9：How to fluorescently label the non-enzymatic proteins?: Speaker：Li Minyong (Shandong University, China)
IL-10：Research on the bioactivity and mechanism of He-Wei granules (HWKL) against the side effects of cisplatin: Speaker：Jun Yin (Shenyang Pharmaceutical University, China)

11:00～12:00

●Invited lectures

【Session 4】

Chair: Takuya Ito (Osaka Ohtani University)

IL-11：Target based lead discovery from natural sources; estrogen receptor modulators and HCV protease inhibitors as examples: Speaker：Ali Mahmoud El-Halawany (Cairo University, Egypt)
IL-12：Application of DART-TOF-MS in natural products and herbal medicines analysis: Speaker：Young Pyo Jang (Kyung Hee University, Korea)
IL-13：Herbs standardization for quality control of indonesian herbal medicine: Speaker：Subehan Ambo Lallo (University of Hasanuddin, Indonesia)

12:00～13:00

●Lunch Break

13:00～14:25

●Invited lectures

【Session 5】

Chair: Hiroaki Sakurai (University of Toyama)

IL-14：Targeting inflammatory tumor microenvironment for developing new cancer treatment: Speaker：Yoshihiro Hayakawa (University of Toyama)
IL-15：Immunomodulatory effects of Lactobacillus sakei K040706 in cyclophosphamide- induced immunosuppressed and dextran sulfate sodium-induced colitis mice: Speaker：Kyung-Tae Lee (Kyung Hee University, Korea)
IL-16：ERK-mediated feedback regulation of ErbB family via the conserved Thr phosphorylation: Speaker：Yuki Kawasaki (Takasaki University of Health and Welfare)
IL-17：The potential role of non-coding RNAs in ovarian cancer: Speaker：Jung-Hye Choi (Kyung Hee University, Korea)
IL-18：Anti-cancer effects of cardiac glycosides by regulating the membrane distribution of glucose transporter-1: Speaker：Takuto Fujii (University of Toyama)

14:40～15:35

●Invited lectures

【Session 6】

Chair: Hisanori Nambu (University of Toyama)

IL-19：Development of new bioorthogonal ligation triggered by 4-membered ring opening: Speaker：Aki Kohyama (University of Toyama)
IL-20：Gluconoamidinylsulfone as a new promising antidiabetic agent: a comprehensive study based on the click-type reaction of thioamide and sulfonyl azide: Speaker：Muhammad Aswad (University of Hasanuddin, Indonesia)
IL-21：The discovery and evaluation of an indenopyrazole derivative LL-01 as an anticancer agent targeting tubulin colchicine binding site: Speaker：Liu Zhaopeng (Shandong University, China)

15:45～16:40

●Invited lectures

【Session 7】

Chair: Meselhy R. M. Zayed (Cairo University, Egypt)

IL-22：Biosynthesis study on asukamycin: Speaker：Takuya Ito (Osaka Ohtani University)
IL-23：Two distinct substrate binding modes for the normal and reverse prenylation by AmbP3: Speaker：Chin Piow Wong (University of Toyama)
IL-24：Diterpenoids with Nrf2 activating activity and their protection effects against oxidative insults in human bronchial epithelial cells: Speaker：Wang Xiaoning (Shandong University, China)

September 12 (Wednesday), 2018

10:00～12:00: ●Poster Session, Session 2
12:00～12:05: ●Closing Remarks
Chairman：Hideki Sakai（University of Toyama）

[PDF;2.3MB]

Date：September 25（Mon）- 26（Tue）, 2017
Venue：At Xuefu Hotel, Jinan, China（6 Qianfoshan, Lixia, Jinan, Shandong, P.R. China 250000）

Report
Award

September 25 (Monday)

8:40～8:55

●Opening Remarks
Host: Prof. Xinyong Liu (Shandong University, China)
Speaker: Prof. Fengshan Wang (Shandong University, China)

9:00～11:45

●Lectures

【Session1】Isolation of new bioactive compounds and Pharmacognosy

Chairs: Fengshan Wang (Shandong University, China), Takuya Ito (University of Toyama, Japan)

9:00-9:30: IL-1.1：Antivirulent Metabolites From Chinese Liverworts
Lecturer: Hongxiang Lou (Shandong University, China)
9:30-10:00: IL-1.2：Development of alternative resources of herbal drug through integrated approaches based on genetic and chemical diversity
Lecturer: Shu Zhu (University of Toyama, Japan)
10:00-10:30: IL-1.3：Synthetic Biology Approaches to the Structure Optimization of Ansamycins
Lecturer: Yuemao Shen (Shandong University, China)
10:30-10:45: Short break
10:45-11:15: IL-1.4：Identification and characterization of daurichromenic acid synthase active in anti-HIV biosynthesis
Lecturer: Futoshi Taura (University of Toyama, Japan)
11:15-11:45: IL-1.5：Bioactive alkaloids from Portulaca oleracea
Lecturer: Lan Xiang (Shandong University, China)

11:45～13:00

●Lunch break

13:00～14:30

●Lectures

【Session2】Biological sciences

Chair: Zhaopeng Liu (Shandong University, China)

13:00-13:30: IL-2.1：Feedback regulation of ErbB family via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain
Lecturer: Yuki Kawasaki (University of Toyama, Japan)
13:30-14:00: IL-2.2：Studies on STAT3-targeting strategies in HCC therapy
Lecturer: Jian Zhang (Shandong University, China)
14:00-14:30: IL-2.3：The inhibitory mechanisms of Shakuyakukanzoto (芍藥甘草湯 Sháo Yào Gān Cǎo Tāng) on chemotherapy-induced peripheral neuropathy
Lecturer: Tsugunobu Andoh (University of Toyama, Japan)

14:30～14:45

●Short break

14:45～17:30

●Lectures

【Session3】Synthesis of new bioactive compounds and Medicinal chemistry

Chairs: Hao Fang (Shandong University, China), Yuji Matsuya (University of Toyama, Japan)

14:45-15:15: IL-3.1：Design, synthesis and antiviral activity evaluation of novel“Multiple-Sites Binding”-typed influenza virus neuraminidase inhibitors
Lecturer: Xinyong Liu (Shandong University, China)
15:15-15:45: IL-3.2：Development of cage-shaped and three-armed molecules with pyridine–acetylene– phenol units as artificial saccharide receptors
Lecturer: Yuki Ohishi (University of Toyama, Japan)
15:45-16:15: IL-3.3：Visualizing the Biological Activity by Firefly Bioluminescence
Lecturer: Minyong Li (Shandong University, China)
16:15-16:30: Short break
16:30-17:00: IL-3.4：Divergent total synthesis of heterocycle-containing sphingosine related natural products, pachastrissamine and penaresidin B
Lecturer: Tomoya Fujiwara (University of Toyama, Japan)
17:00-17:30: IL-3.5：Uncovering the Catalytic Mode of Heparan Sulfate N-Deacetylase/N-sulfotransferase-4
Lecturer: Juzheng Sheng (Shandong University, China)

18:00～20:00

●Banquet (Xuefu Hotel)

September 26 (Tuesday)

8:30～9:30: ●Poster Session
9:45～10:00: ●Closing Remarks
The Chairman of 2nd International Symposium on TAA-Pharm Net:
Ken-ichi Hosoya (University of Toyama, Japan), Xinyong Liu (Shandong University, China)

[PDF;320KB]

The 2nd TAA-Pharm Symposium was held.

As one of our activities for “the establishment of Toyama-Asia-Africa Pharmaceutical Network (TAA Pharmnet)”, approved by Japan Society for the Promotion of Science, Core-to-Core Program (B. Asia-Africa Science Platforms), the title symposium was held at Shandong University, China on September 25 and 26. In the symposium, 13 invited lectures and 34 poster lectures were presented and the latest drug research results were discussed. From University of Toyama 10 professors and 12 students went to China and 29 Chinese professors and researchers and 14 Chinese students participated.
The 3rd TAA Pharm Symposium will be held at Toyama International Conference Center next September.

2nd TAA-Pharm Symposium Poster Award

○University of Toyama

Ju Ye（鞠嘩）（Natural Products Chemistry, Institute of Natural Medicine）
Combinatorial biosynthesis of aloeson analog by exploiting a type III polykeitde synthase and olivetlic acid cyclase
Han-Pei Zhang（張含培）（Pharmacognosy, Institute of Natural Medicine）
Applying trnH-psbA intergenic spacer sequence to identify Drynariae Rhizoma
Rintaro Kida（木田凛太郎）（Biopharmaceutics）
Functional analysis of Oatp1a4 in the liver by fluorescent substrate
Takashi Kikukawa（菊川孝）（Applied Pharmacology）
Inhibitory effect of methylcobalamin on mechanical allodynia in mice infected with herpes simplex virus type-1
Kanae Takahashi（高橋果菜恵）（Synthetic and Biomolecular Organic Chemistry）
Chemo- and stereoselective Rh(II)-catalyzed 6-membered O-ylide formation−[2,3]-sigmatropic rearrangement of 2-diazo-3-ketoesters

○Shandong University

Yuefang Zhou
Chemical constituents with potential neuroprotective activity from hemp (Cannabis sativa L.) seed
Lin Sun
First discovery of novel 5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivitaves as potent HIV-1 RNase H inhibitors Via “Privileged Structure”reposition
Yi Zhou
Novel N-benzylpyrimidin-2-amine derivatives as histone deacetylase (HDAC) inhibitor: design, synthesis and preliminary bioactivity evaluation
Xiu-Xiu Wang
Design, synthesis and tumor cell growth inhibitory activity of 3-nitro-2H-cheromene derivatives as histone deacetylaes inhibitors
Wenjie Jiang
Sulfated Polysaccharide of Sepiella maindroni Ink Inhibits Migration, Invasion and MMP-2 Expression through EGFR-Mediated PI3K-Akt-mTOR and p38/MAPK Signaling Pathways

Date：September 12（Mon）- 13（Tue）, 2016
Venue：Toyama International Conference Center

September 12 (Monday)

8:55～9:00

●Opening Remarks
Opening Remarks: Ken-ichi Hosoya (University of Toyama)

9:00～12:00

●Invited lectures

【Session 1】Isolation of new bioactive compounds and Pharmacognosy: Chair：Abdel-Sattar (Cairo University, Egypt) and Hiroyuki Morita (University of Toyama); Lecturers：Prof. Shaojiang Song (Shenyang Pharmaceutical University, China), Prof. Gemini Alam (University of Hasanuddin, Indonesia), Dr. Subehan Ambo Lallo (University of Hasanuddin, Indonesia), Prof. Meselhy Ragab Meselhy Zayed (Cairo University, Egypt), Dr. Kazufumi Toume (University of Toyama), Dr. Takuya Ito (University of Toyama)

13:00～14:45

●Poster Presentations

15:00～18:00

●Invited lectures

【Session 2】Biological sciences: Chair：Kyung Tae Lee (Kyung Hee University, Korea) and Tsuneo Imanaka (University of Toyama); Lecturers：Prof. Fenshan Wang (Shandong University, China), Prof. Myung Sook Oh (Kyung Hee University, Korea), Dr. Noritaka Nakamichi (Kanazawa University), Prof. Yasuhide Mitsumoto (Hokuriku University), Dr. Masashi Morita (University of Toyama), Dr. Yoshiyuki Kubo (University of Toyama)

18:15～20:00

●Banquet (Toyama International Conference Center)

September 13 (Tuesday)

9:00～12:00

●Invited lectures

【Session 3】Synthesis of new bioactive compounds and Medicinal chemistry: Chair：Yuji Matsuya and Hisanori Nambu (University of Toyama); Lecturers：Prof. Xinyong Liu (Shandong University, China), Prof. Yin Jun (Shenyang Pharmaceutical University, China), Prof. Naoki Toyooka (University of Toyama), Prof. Hitoshi Abe (University of Toyama), Dr. Kenji Sugimoto (University of Toyama), Dr. Muhammad Aswad (University of Hasanuddin, Indonesia)

12:00

●Closing Ceremony

The 1st TAA-Pharm Symposium was held.

The establishment of Toyama-Asia-Africa Pharmaceutical Network (TAA Pharmnet), which is based on traditional and natural drug use in the pharmaceutical department, is a project to establish a research core approved by Japan Society for the Promotion of Science, Core-to-Core Program (B. Asia-Africa Science Platforms). As one of our activities, the title symposium was held at the Toyama International Conference Center on September 12 and 13. Ten researchers were invited from five universities in Asia and Africa. 18 Invited lectures and 59 poster lectures were presented and latest drug research results were shown. Approximately 150 participants participated in the symposium, with professors, doctors, students, and corporate researchers.

Date：January 22（Mon）, 2018
Venue：Cairo University, Egypt

Report

January 22（Mon）

Moderator：Prof. Meselhy Ragab (Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt)

10:00～10:10

●Opening Remarks
Speaker：Prof. Aiman S.N. El-Khatib（Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt）

10:15～10:35

●Lecture【1】

New Organocatalysts for Oxidation Reactions: Lecturer：Prof. Takayuki Yakura（Department of Synthetic and Bioorganic Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan）

10:40～11:00

●Lecture【2】

Discovery of New Bioactive Compounds from Natural Sources and by Engineering Approaches of Secondary Metabolite Enzymes: Lecturer：Prof. Hiroyuki Morita（Department of Natural Products Chemistry & Medicinal Resources, Institute of Natural Medicine, University of Toyama, Japan）

11:00～11:20

●Lecture【3】

"Non-natural" Natural Product Strategy: Design and Synthesis of Potential Anticancer Compounds Based on Natural Products: Lecturer：Prof. Yuji Matsuya（Department of Synthetic and Medicinal Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan）

11:20～11:50

●Coffee break

11:50～12:10

●Lecture【4】

Non-canonical activation of receptor tyrosine kinases in lung cancer cells: Lecturer：Prof. Hiroaki Sakurai（Laboratory of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan）

12:10～12:30

●Lecture【5】

Roles of the blood retinal barrier transporters in retinal drug delivery: Lecturer：Prof. Ken-ichi Hosoya（Professor of Biopharmaceutics & Dean, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan）

12:30～12:40

●Closing Remarks
Speaker：Prof. Essam Abdel-Sattar（Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt）

TAA2-Joint Seminar

Cairo University and University of Toyama Joint Seminar was held.

The Joint Seminar 'Recent Advances in Drug Discovery and Biopharmaceutics' was held at Cairo University, Egypt on January 22. From University of Toyama 5 professors and more than 10 professors from Cairo University participated.