2005年以降 富山発の論文

Hisanori Nambu, Wataru Hirota, Masahiro Fukumoto, Takafumi Tamura, and Takayuki Yakura
An efficient route to highly substituted indoles via tetrahydroindol-4(5H)-one intermediates produced by ring-opening cyclization of spirocyclopropanes with amines
Chem. Eur. J., Early View (DOI: 10.1002/chem.201702622).
(selected as Hot Paper & Cover Picture)
Link: Paper, Cover Picture, 富山大学HP, 薬学部HP, 富山大学プレスリリース

新聞記事



Cover Picture (ASAP)


Narumi Noda, Hisanori Nambu, Tomoya Fujiwara, and Takayuki Yakura
Total synthesis of sphingofungin E and 4,5-di-epi-sphingofungin E
Chem. Pharm. Bull., 65, 687–696 (2017).

Narumi Noda, Hisanori Nambu, Kana Ubukata, Tomoya Fujiwara, Kiyoshi Tsuge and Takayuki Yakura

Total synthesis of myriocin and mycestericin D employing Rh(II)-catalyzed C-H amination followed by stereoselective alkylation
Tetrahedron, 73, 868–878 (2017).

Takayuki Yakura, Hisanori Nambu and Tomoya Fujiwara
Development of novel catalytic system, iodoarene-oxone, on hypervalent iodine oxidation of phenols and alcohols
J. Synth. Org. Chem. Jpn., 75, 209–218 (2017).

Hisanori Nambu, Naoki Ono, Wataru Hirota, Masahiro Fukumoto and Takayuki Yakura
An efficient method for the synthesis of 2',3'-nonsubstituted cycloalkane-1,3-dione-2-spirocyclopropanes using (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate
Chem. Pharm. Bull., 64, 1763–1768 (2016).

Shizuka Mizoguchi, Tsugunobu Andoh, Takayuki Yakura and Yasushi Kuraishi

Involvement of c-Myc-mediated transient receptor potential melastatin 8 expression in oxaliplatin-induced cold allodynia in mice
Pharmacol Rep, 68, 645–648 (2016).

Hisanori Nambu, Naoki Ono and Takayuki Yakura
Acid-catalyzed ring-opening cyclization of spirocyclopropanes for the construction of a 2-arylbenzofuran skeleton: total synthesis of cuspidan B
Synthesis, 48, 1892–1901 (2016).

Hisanori Nambu, Ikumi Shimokawa, Tomoya Fujiwara and Takayuki Yakura
Recyclable magnetic nanoparticle-supported iodoarene catalysts for oxidation of 4-alkoxyphenols to quinones
Asian. J. Org. Chem., 5, 486–489 (2016).

Hisanori Nambu, Hikari Jinnouchi, Tomoya Fujiwara and Takayuki Yakura
Total synthesis of (+)-tanikolide by a traceless stereoinduction method using Rh(II)-catalyzed oxonium ylide formation–[2,3]-sigmatropic rearrangement and NHC-catalyzed ring-expansion lactonization
Synlett, 27, 1106–1109 (2016).

Bo Liu, Kazuki Hashimoto, Hisanori Nambu, Tomoya Fujiwara and Takayuki Yakura
Synthetic studies on pachastrissamine sulfur analogue: synthesis of 4-epi-sulfur analogue
Chem. Pharm. Bull., 64, 366–370 (2016).

Takayuki Yakura, Yuto Horiuchi, Yushi Nishimura, Akihiro Yamada, Hisanori Nambu and Tomoya Fujiwara
Efficient oxidative cleavage of tetrahydrofuran-2-methanols to γ-lactones by a 2-iodobenzamide catalyst in combination with oxone®
Adv. Synth. Catal., 358, 869–873 (2016).

Tomoya Fujiwara, Bo Liu, Wenqi Niu, Kazuki Hashimoto, Hisanori Nambu and Takayuki Yakura
Practical synthesis of pachastrissamine (jaspine B), 2-epi-pachastrissamine, and the 2-epi-pyrrolidine analogue
Chem. Pharm. Bull., 64, 179–188 (2016).

Hisanori Nambu, Narumi Noda, Wenqi Niu, Tomoya Fujiwara and Takayuki Yakura
Stereoselective total synthesis of myriocin using Rh(II)-catalyzed C-H amination followed by alkylation
Asian. J. Org. Chem., 4, 1246–1249 (2015).

Hisanori Nambu, Masahiro Fukumoto, Wataru Hirota, Naoki Ono and Takayuki Yakura
An efficient synthesis of cycloalkane-1,3-dione-2-spirocyclopropanes from 1,3-cycloalkanediones using (1-aryl-2-bromoethyl)-dimethylsulfonium bromides: application to a one-pot synthesis of tetrahydroindol-4(5H)-one
Tetrahedron Lett., 56, 4312–4315 (2015).

Tomoya Fujiwara, Hiroko Yasuda, Yushi Nishimura, Hisanori Nambu and Takayuki Yakura
Synthesis of 10b-fluorinated analogues of protubonine A and its 11a-epimer via fluorocyclisation of tryptophan-containing dipeptides
RSC Adv., 5, 5464–5473 (2015).

Hisanori Nambu, Masahiro Fukumoto, Wataru Hirota and Takayuki Yakura
Ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes with amines: Rapid access to 2‑substituted 4‑hydroxyindole
Org. Lett., 16, 4012–4015 (2014).

Tomoya Fujiwara, Takayuki Seki, Takayuki Yakura and Yoshio Takeuchi
Useful procedures for fluorocyclization of tryptamine and tryptophol derivatives to 3a-fluoropyrrolo[2,3-b]indoles and 3a-fluorofuro[2,3-b]indoles
J. Fluorine Chem., 165, 7–13 (2014).

Takayuki Yakura, Akihiro Yamada, Narumi Noda, Tomoya Fujiwara and Hisanori Nambu
A 2-iodobenzamide catalyst for oxidation of alcohols at room temperature
Asian. J. Org. Chem., 3, 421–424 (2014).

Takayuki Yakura, Ayaka Ozono, Katsuaki Matsui, Masayuki Yamashita and Tomoya Fujiwara
Application of a stereoselective rhodium(II)-catalyzed oxonium ylide formation−[2,3]-sigmatropic rearrangement of an α-diazo-β-keto ester to the synthesis of 2-epi-cinatrin C1 dimethyl ester
Synlett, 24, 65–68 (2013).

Takayuki Yakura and Ayaka Ozono
Novel 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-iodobenzene hybrid catalyst for oxidation of primary alcohols to carboxylic acids
Adv. Synth. Catal., 353, 855–859 (2011).

Takayuki Yakura, Ayaka Ozono and Kohei Morimoto
An efficient catalytic oxidation of p-alkoxypenols to p-quinones using tetrabutylammonium bromide and Oxone
Chem. Pharm. Bull., 59, 132–134 (2011).

Takayuki Seki, Tomoya Fujiwara and Yoshio Takeuchi
A facile procedure for synthesis of 3-[2-(N,N-dialkylamino)ethyl]-3- fluorooxindoles by direct fluorination of N,N-dialkyltryptamines
J. Fluorine Chem., 132, 181–185 (2011).

Takayuki Yakura, Masanori Omoto, Yu Yamauchi, Yuan Tian and Ayaka Ozono
Hypervalent iodine oxidation of phenol derivatives using a catalytic amount of 4-iodophenoxyacetic acid and Oxone as a co-oxidant
Tetrahedron, 66: 5833–5840, (2010).

Kenji Omata, Kohsuke Kotani, Kuninobu Kabuto, Tomoya Fujiwara and Yoshio Takeuchi
Confirmation by IR of the preferred conformations of CFTA esters in solution: a highly reliable criterion for the stereochemistry assignment of chiral alcohols
Chem. Commun., 46, 3610–3612 (2010).

Tomoya Fujiwara and Yoshio Takeuchi
Application of chiral α-monofluorocarbonyl compounds to analytical and medicinal chemistry
Curr. Org. Chem., 14, 950–961 (2010).

Takayuki Yakura and Masanori Omoto
Efficient synthesis of p-quinols using catalytic hypervalent iodine oxidation of 4-arylphenols with 4-phenoxyacetic acid and Oxone
Chem. Pharm. Bull., 57, 646–645 (2009).

Takayuki Yakura, Katsuaki Matsui, Kazumasa Matsuzaka and Masayuki Yamashita
Stereoselective synthesis of 5-substituted 2-allyl-3-oxotetrahydrofuran-2-carboxylates using rhodium(II)-catalyzed oxonium ylide formation-[2,3] shift
Heterocycles, 79, 353–358 (2009).

Tomoya Fujiwara, Takayuki Seki, Masaru Miura and Yoshio Takeuchi
Synthetic studies on the fluorinated analogs for the putative oxindole-type metabolites of 5-halotryptamines
Heterocycles, 79, 427–432 (2009).

Takayuki Yakura, Yu Yamauchi, Yuan Tian and Masanori Omoto
Catalytic hypervalent iodine oxidation of p-dialkoxybenzenes to p-quinones using 4-iodophenoxyacetic acid and Oxone
Chem. Pharm. Bull., 56, 1632–1634 (2008).
(selected as Cover Picture)

Yoshio Takeuchi, Tomoya Fujiwara, Yoshihito Shimone, Hideki Miyataka, Toshio Satoh, Kenneth L. Kirk and Hitoshi Hori
Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides
Bioorg. Med. Chem. Lett., 18, 6202–6205 (2008).

Tomoya Fujiwara, Bin Yin, Meixiang Jin, Kenneth L. Kirk and Yoshio Takeuchi
Synthetic studies of 3-(3-fluorooxindol-3-yl)-L-alanine
J. Fluorine Chem., 129, 829–835 (2008).

Yoshihiro Uto, Hideko Nagasawa, Cheng-Zhe Jin, Shinichi Nakayama, Ayako Tanaka, Saori Kiyoi, Hitomi Nakashima, Mariko Shimamura, Seiichi Inayama, Tomoya Fujiwara, Yoshio Takeuchi, Yoshimasa Uehara, Kenneth L. Kirk, Eiji Nakata and Hitoshi Hori
Design of antiangiogenic hypoxic cell radiosensitizers: 2-nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety
Bioorg. Med. Chem., 16, 6042–6053 (2008).

Tomoya Fujiwara, Masaru Segawa, Hidehito Fujisawa, Taiki Murai, Tamiko Takahashi, Kenji Omata, Kuninobu Kabuto, Siegfried N. Lodwig, Clifford J. Unkefer and Yoshio Takeuchi
Reliable assignment of absolute configuration of chiral amines based on the analysis of 1H NMR spectra of their CFTA amide diastereomers
Tetrahedron: Asymmetry, 19, 847–856 (2008).

Dirk J. Brand, Jacobus A. Steenkamp, Kenji Omata, Kuninobu Kabuto, Tomoya Fujiwara and Yoshio Takeuchi
The origin of an unusually large 19F chemical shift difference between the diastereomeric α-cyano-α-fluoro-p-tolylacetic Acid (CFTA) esters of 3',4',5,7-tetra-O-methylepicatechin
Chirality, 20, 351–356 (2008).

Takayuki Yakura, Yuya Yoshimoto and Chisaki Ishida
Dirhodium(II)- catalyzed C-H amination reaction of (S)-3-(tert-butyldimethyl- silyloxy)-2-methylpropyl carbamate: A facile preparation of optically active monoprotected 2-amino-2-methyl-1,3-propanediol
Chem. Pharm. Bull., 55, 1385–1389 (2007).

Takayuki Yakura, Seiichi Sato and Yuya Yoshimoto
Enantioselective Synthesis of Pachastrissamine (Jaspin B) using Dirhodium(II)-catalyzed C-H Amination and Asymmetric Dihydroxylation as Key Steps
Chem. Pharm. Bull., 55, 1284–1286 (2007).

Takayuki Yakura, Yuya Yoshimoto, Chisaki Ishida and Shunsuke Mabuchi
Synthesis of an immunomodulator (+)-conagenin and its analogs
Tetrahedron, 63, 4429–4438 (2007).

Takayuki Yakura and Tatsuya Konishi
A novel catalytic hypervalent iodine oxidations of p-alkoxyphenols to p-quinones using 4-iodophenoxyacetic acid and Oxone
Synlett, 765–768 (2007).

Takayuki Yakura, Yuya Yoshimoto, Chisaki Ishida and Shunsuke Mabuchi
Stereoselective synthesis of an immunomodulator (+)-conagenin using dirhodium(II)-catalyzed C-H amination and chelation-controlled reductions as key steps
Synlett, 930–932 (2006).

Takayuki Yakura, Wataru Muramatsu and Jun'ichi Uenishi
Stereoselective synthesis of C3-C12 dihydropyran portion of antitumor laulimalide using copper-catalyzed oxonium ylide formation-[2,3] shift
Chem. Pharm. Bull., 53, 1436–1437 (2005).

Yoshio Takeuchi, Hidehito Fujisawa, Tomoya Fujiwara, Mamoru Matsuura, Hirotsugu Komatsu, Satoshi Ueno and Takeshi Matsuzaki
Biological evaluation of 2-aryl-2-fluoropropionic acids as possible platforms for new medicinal agents
Chem. Pharm. Bull, 53, 1062–1064 (2005).

Hidehito Fujisawa, Tomoya Fujiwara, Yoshio Takeuchi and Kenji Omata
Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of non-steroidal anti-inflammatory drugs (NSAIDs)
Chem. Pharm. Bull., 53, 524–528 (2005).

Tomoya Fujiwara and Yoshio Takeuchi
Synthesis, reactions, and applications of fluorine-containing multifunctional carbon compounds
J. Fluorine Chem., 126, 941–955 (2005).