植物二次代謝機構の解明
Elucidation of Plant Secondary Metabolism

Functional characterization of three diterpene synthases responsible for tetracyclic diterpene biosynthesis in Scoparia dulcis.
LEE J.B., OHMURA T. & YAMAMURA Y. Plants 2023 12, 69.

Characterization of ent-kaurene synthase and kaurene oxidase involved in gibberellin biosynthesis from Scoparia dulcis.
YAMAMURA Y., ICHITANI K., UMEBARA I., OHSHITA A., & LEE J.B., J. Nat. Med. 2018 72, 456-63.

Elucidation of terpenoid metabolism in Scoparia dulcis by RNA-seq analysis.
YAMAMURA Y., KUROSAKI F. & LEE J.B., Sci. Rep. 2017 7, 69.

有用天然物の探索と評価
Discovery of Bioactive Natural Products

Therapeutic effects of a dry powder prepared from the green microalga Coccomyxa sp. KJ in mce Infected with influenza A virus.
HAYASHI K., KUNO H., KOMATSU S., LEE J.B., & KAWAHARA T. Appl. Microbiol. 2022 2, 481-91.

Anti-influenza A virus activity of rhamnan sulfate from green algae Monostroma nididum in mice with normal and compromised immunity.
TERASAWA M., HAYASHI K., LEE J.B., NISHIURA K., MATSUDA K., HAYASHI T. & KAWAHARA T., Mar. Drugs 2020 18, 5.

In vitro and in vivo anti-herpes simplex virus activity of monogalactosyl diacylglyceride from Coccomyxa sp. KJ (IPOD FERM BP-22254), a green microalga
HAYASHI K., LEE J.B., ATSUMI K., KANAZASHI M., SHIBAYAMA T., OKAMOTO K. & KAWAHARA T., PLoS One 2019 14, e0219305.

優良系統植物の選抜・育種
Selection and Bleeding of Superior Plant Lines

薬用植物および生薬の持続的生産には，優良な形質を持つ新品種の選抜や育種が必要となっている。物質生産能だけでなく，耐病性や耐寒性など考慮しながら，薬用資源としての植物の資質向上を目指している。

The sustainable production of medicinal plants and crude drugs requires the selection and bleeding of new varieties with superior traits. We aim to improve the qualities of plants as medicinal resources, taking into consideration not only their substance production ability but also their disease and cold resistances.

学会発表
Presentation of Academic Meetings

2023

"A novel C-12 oxidase, CYP76AH93, is involved in abietane-type diterpene biosynthesis in Isodon japonicus", YAMAMURA Y., OHMORI S., & LEE J.B., 2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Sep. 25-29, 2023 (Shizuoka, Japan)

"天然物化学からのウイルス感染症へのチャレンジ", 李 貞範, 日本薬学会北陸支部第135例会（シンポジウム「感染症との共存社会を考える」）, Nov. 26, 2023 (金沢).

"ハナビラタケ由来β-グルカンの構造解析", 浅野圭志, 春日勝芳, 李 貞範, 日本生薬学会第69年会, Sep. 9-10, 2023（仙台）.

"ヒキオコシ由来ジテルペン合成酵素の解明", 吉野遙香, 山村良美, 李 貞範, 日本生薬学会第69年会, Sep. 9-10, 2023（仙台）.