Articles

Chau CH, Chen KY, Deng HT, Kim KJ, Hosoya K, Terasaki T, Shih HM, Ann DK.
Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation.
Oncogene. 2002 Dec 12;21(57):8817-29.

Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T.
The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain.
J Cereb Blood Flow Metab. 2002 Nov;22(11):1327-35.

Kang YS, Ohtsuki S, Takanaga H, Tomi M, Hosoya K, Terasaki T.
Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity.
J Neurochem. 2002 Dec;83(5):1188-95.

Hosoya K, Ohtsuki S, Terasaki T.
Recent advances in the brain-to-blood efflux transport across the blood-brain barrier.
Int J Pharm. 2002 Nov 6;248(1-2):15-29.

Deguchi Y, Okutsu H, Okura T, Yamada S, Kimura R, Yuge T, Furukawa A, Morimoto K, Tachikawa M, Ohtsuki S, Hosoya K, Terasaki T.
Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan.
J Neurochem. 2002 Oct;83(2):381-9.

Hosoya K, Takashima T, Matsuda K, Terasaki T.
Spleen lymphocyte kinetics in mice under normal and inflammatory conditions: an application of the transgenic mouse expressing beta-galactosidase (ROSA 26).
Biol Pharm Bull. 2002 Oct;25(10):1378-80.

Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T.
Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.
J Neurochem. 2002 Oct;83(1):57-66.

Wakayama K, Ohtsuki S, Takanaga H, Hosoya K, Terasaki T.
Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells.
Neurosci Res. 2002 Oct;44(2):173-80.

Hosoya K, Tomi M, Ohtsuki S, Takanaga H, Saeki S, Kanai Y, Endou H, Naito M, Tsuruo T, Terasaki T.
Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.
J Pharmacol Exp Ther. 2002 Jul;302(1):225-31.

Takanaga H, Tokuda N, Ohtsuki S, Hosoya K, Terasaki T.
ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline.
Mol Pharmacol. 2002 Jun;61(6):1289-96.

Asashima T, Iizasa H, Terasaki T, Hosoya K, Tetsuka K, Ueda M, Obinata M, Nakashima E.
Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-beta1 and beta-glycerophosphate.
Eur J Cell Biol. 2002 Mar;81(3):145-52.

Tomi M, Hosoya K, Takanaga H, Ohtsuki S, Terasaki T.
Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier.
Invest Ophthalmol Vis Sci. 2002 Mar;43(3):774-9.

Kakee A, Takanaga H, Hosoya K, Sugiyama Y, Terasaki T.
In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier.
Microvasc Res. 2002 Mar;63(2):233-8.

Books and Reviews

細谷健一: 薬物の分布,「INTEGRATED ESSENTIALS薬剤学」, 改訂第6版, 花野　学他編, 203-219, 南江堂, 東京, 2002.

片山和憲，細谷健一: 薬物の排池,「INTEGRATED ESSENTIALS薬剤学」, 改訂第6版, 花野　学他編, 236-252, 南江堂, 東京, 2002.

Hosoya K.，Ohtsuki S.，and Terasaki T.: Blood-brain barrier transport and drug targeting to the brain，In Biomedical aspects of drug targeting，by Muzykantov V.R.，and Torchil in V.P.(Ed.) 313-326，Kluwer，New York，2002.

片山和憲: 物質の変形と流動,「わかりやすい物理薬剤学」, 第3版, 辻　彰, 河島　進編, 119-133, 廣川書店, 東京, 2002.

片山和憲: 各種剤形と物理薬剤学,「わかりやすい物理薬剤学」, 第3版, 辻　彰, 河島　進編, 195-206, 廣川書店, 東京, 2002.

Terasaki T.，Ohtsuki S.，Hori S.，and Hosoya K.: Blood-brain barrier transport biology and drug delivery to the brain，In Advance in biomaterials and drug delivery systems，by Hsiue G.H. et al.(Ed.) 499-516，Princeton Int. Pub. Co.，Taipei，2002.

Hosoya K.，Ohtsuki S.，and Terasaki T.: Recent advances in the brain-to-blood efflux transport across the blood-brain barrier. Int. J. Pharm.. 248:15-29. 2002.