富山大学大学院・医学薬学研究部(薬学)
医療薬学研究室  
Department of  Community Pharmacy 保険薬局学研究室
       
〜本研究室は、臨床応用を目指した研究室です〜
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富山大学HP
薬学部HP


〒930-0194
富山県富山市杉谷2630


 
  2017年
Okazaki F, Matsunaga N, Hamamura K, Suzuki K, Nakao T, Okazaki H, Kutsukake M, Fukumori S, Tsuji Y, To H. Administering xCT inhibitors based on circadian clock improves antitumor effects. Cancer Res. 2017 Oct 16. pii: canres.0720.2017.

Koyama A, Tanaka A, To H. Daily oral administration of low-dose methotrexate has greater antirheumatic effects in collagen-induced arthritis rats. J Pharm Pharmacol. 2017 Sep;69(9):1145-1154.

Seto Y, Takase M, Tsuji Y, To H. Pregabalin reduces cisplatin-induced mechanical allodynia in rats. J Pharmacol Sci. 2017 Jul;134(3):175-180.

Yamashina T, Tsuruyama M, Odawara M, Tsuruta M, Miyata H, Kozono A, Tsuji Y, Miyoshi T, Kawamata Y, Hiraki Y. Pharmacokinetics of linezolid during continuous hemodiafiltration: A case report. J Infect Chemother. 2017 Oct;23(10):709-712.

Nishijo N, Tsuji Y, Matsunaga K, Kutsukake M, Okazaki F, Fukumori S, Kasai H, Hiraki Y, Sakamaki I, Yamamoto Y, Karube Y, To H. Mechanism Underlying Linezolid-induced Thrombocytopenia in a Chronic Kidney Failure Mouse Model. J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):8-13.

Tsuji Y, Holford NHG, Kasai H, Ogami C, Heo YA, Higashi Y, Mizoguchi A, To H, Yamamoto Y. Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients. Br J Clin Pharmacol. 2017 Aug;83(8):1758-1772.

Ogami C, Tsuji Y, Kasai H, Hiraki Y, Yamamoto Y, Matsunaga K, Karube Y, To H. Evaluation of pharmacokinetics and the stability of daptomycin in serum at various temperatures. Int J Infect Dis. 2017 Apr;57:38-43.

  2016年
Seto Y, Okazaki F, Horikawa K, Zhang J, Sasaki H, To H. Influence of dosing times on cisplatin-induced peripheral neuropathy in rats. BMC Cancer. 2016 Sep 27;16(1):756.

Muraki Y, Yagi T, Tsuji Y, Nishimura N, Tanabe M, Niwa T, Watanabe T, Fujimoto S, Takayama K, Murakami N, Okuda M. Japanese antimicrobial consumption surveillance: First report on oral and parenteral antimicrobial consumption in Japan (2009-2013). J Glob Antimicrob Resist. 2016 Aug 6;7:19-23.

Kozono A, Hiraki Y, Adachi R, Nagano M, Inoue D, Tsuji Y, Kamimura H, Karube Y. Comparison of predictive accuracy of teicoplanin concentration using creatinine clearance and glomerular filtration rate estimated by serum creatinine or cystatin C. J Infect Chemother. 2016 May;22(5):314-8.

Ashizawa N, Tsuji Y, Kawago K, Higashi Y, Tashiro M, Nogami M, Gejo R, Narukawa M, Kimura T, Yamamoto Y. Successful treatment of methicillin-resistant Staphylococcus aureus osteomyelitis with combination therapy using linezolid and rifampicin under therapeutic drug monitoring. J Infect Chemother. 2016 May;22(5):331-4.

Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S. Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression. J Biol Chem. 2016 Mar 25;291(13):7017-28.

  2015年
論文
Hiraki Y, Tsuji Y, Yasumori N, Nagano M, Inoue D, Kamimura H, Karube Y, Kawano F. Elevations of urinary pH may lower vancomycin serum concentration. Int J Clin Pharmacol Ther. 2015 Dec;53(12):987-96.

Tsuji Y, Iwanaga N, Mizoguchi A, Sonemoto E, Hiraki Y, Ota Y, Kasai H, Yukawa E, Ueki Y, To H. Population Pharmacokinetic Approach to the Use of Low Dose Cyclosporine in Patients with Connective Tissue Diseases. Biol Pharm Bull. 2015;38(9):1265-71.

Tsuji Y, Tashiro M, Ashizawa N, Ota Y, Obi H, Nagura S, Narukawa M, Fukahara K, Yoshimura N, To H, Yamamoto Y. Treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose. Intern Med. 2015;54(2):235-9.

Hiraki Y, Yasumori N, Nagano M, Inoue D, Tsuji Y, Kamimura H, Karube Y. Optimal loading regimen and achievement of trough concentrations for teicoplanin using Japanese population parameters. Int J Antimicrob Agents. 2015 Jan;45(1):87-8.

 
著書
辻泰弘:マクロライド系薬の使い方、二木芳人監修、じほう、「薬学生・薬剤師レジデントのための感染症学・抗菌薬治療テキスト」、341-350、2015.

辻泰弘:リンコマイシン系薬の使い方、二木芳人監修、じほう、「薬学生・薬剤師レジデントのための感染症学・抗菌薬治療テキスト」、351-354、2015.

  2014年
Yoshimatsu H, Okazaki F, Ieiri I, To H. Mechanism of the 24-hour rhythm of tumor necrosis factor-alpha formed by onset of rheumatoid arthritis. Chronobiol Int. 2014 May;31(4):564-71.

Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E. System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts. Biochim Biophys Acta. 2014 May;1838(5):1306-12.

Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S. Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Cancer Res. 2014 Jan 15;74(2):543-51.
       
  2013年
Matsui M, Shibayama K, Tsuji Y, Kamimura H, Karube Y, Yoshida M, Masuda Y, Hiraki Y, Takaki K, Kawano F.Isolation of genetically indistinguishable carbapenem-resistant and -susceptible Acinetobacter baumannii Isolates from a single patient. Antimicrob Agents Chemother., 57: 5781-5782. 2013.

Tsuji Y, Yukawa E, Hiraki Y, Matsumoto K, Mizoguchi A, Morita K, Kamimura H, Karube Y, To H. Population pharmacokinetic analysis of linezolid in low body weight patients with renal dysfunction. J Clin Pharmacol., 53: 967-973. 2013.

Hiraki Y, Yoshida M, Masuda Y, Inoue D, Tsuji Y, Kamimura H, Karube Y, Takaki K, Kawano F. Successful treatment of skin and soft tissue infection due to carbapenem-resistant Acinetobacter baumannii by ampicillin-sulbactam and meropenem combination therapy. Int J Infect Dis., 17:e1234-1236. 2013.

Tsuji Y, Hashimoto W, Taniguchi S, Hiraki Y, Mizoguchi A, Yukawa E, To H. Pharmacokinetics of linezolid in the mediastinum and pleural space. Int J Infect Dis., 17: e1060-1061. 2013.

Hiraki Y, Tsuji Y, Misumi N, Hiraike M, Matsumoto K, Morita K, Kamimura H, Karube Y. Pharmacokinetics and elimination efficiency of linezolid during dialysis.
Ren Fail., 35: 418-420. 2013.

  2012年
Kanasaki Y., Tomonari M., Sasaki H., To H.: Chronopharmacology of mizoribine in collagen-induced arthritis rats. J. Pharmacol. Sci., 120: 112-120, 2012. 

Hiraki Y., Tsuji Y., Hiraike M., Misumi N., Matsumoto K., Morita K., Kamimura H., Karube Y.: Correlation between serum linezolid concentration and the development of thrombocytopenia. Scand. J. Infect. Dis., 44: 60-64, 2012.

Hiraike M., Hiraki Y., Misumi N., Hanada K., Tsuji Y., Kamimura H., Karube Y., Kashiwabara K.: Pharmacokinetics of carboplatin in a hemodialysis patient with small-cell lung cancer. Cancer. Chemother. Pharmacol., 69: 845-848,2012.

Tsuji Y., Hiraki Y., Matsumoto K., Mizoguchi A., Sadoh S., Kobayashi T., Sakamoto S., Morita K., Yukawa E., Kamimura H., Karube Y.: Evaluation of the pharmacokinetics of linezolid in an obese Japanese patient. Scand. J. Infect. Dis., 44: 626:629, 2012.

Hiraki Y., Hiraike M., Shirasawa H., Ozono Y., Manabe K., Misumi N., Tsuji Y., Kamimura H., Karube Y.: Pharmacokinetics and administration method of gentamicin in a patient on hemodialysis. Scand. J. Infect. Dis., 44: 630-634, 2012.

平木洋一、三角紳博、平池美香子、大窪典子、辻泰弘、真鍋健一、石橋誠、神村英利、加留部善晴: TDM (Therapeutic Drug Monitoring) 研修における受講者の理解度の評価. TDM研究, 29, 98-104, 2012.

    2011年
Uematsu M, Kumagami T, Shimoda K, Kusano M, Teshima M, To H, Kitahara T, Kitaoka T, Sasaki H., Polyoxyethylene Hydrogenated Castor Oil Modulates Benzalkonium Chloride Toxicity: Comparison of Acute Corneal Barrier Dysfunction Induced by Travoprost Z and Travoprost.J Ocul Pharmacol Ther. 2011 Jun 29.

Obayashi K, Tomonari M, Yoshimatsu H, FukuyamaR, Ieiri I, Higuchi S, To H., Dosing time-dependency of the arthritis-inhibiting effect of tacrolimus in mice.J Pharmacol Sci. 2011 Jul 15;116(3):264-73. Epub 2011 Jun 18.

To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K., Methotrexate chronotherapy is effective against rheumatoid arthritis.Chronobiol Int. 2011 Apr;28(3):267-74.

Tomonari M, To H, Nishida M, Mishima T, Sasaki H, Kurose H., Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity.J Pharmacol Sci. 2011;115(3):336-45. Epub 2011 Feb 24.

   著書(邦文)分担 
藤秀人;関節リウマチ体内時計機構と時間治療、柴田重信編集 「体内時計の科学と産業応用」pp80-85, 2011
藤秀人;がんの体内時計機構と時間治療、柴田重信編集 「体内時計の科学と産業応用」pp73-79, 2011