Outline

The blood-tissue barriers including blood-retinal barrier form complex tight junctions of capillary endothelial cells and/or epithelial cells. Although these tight barriers prevent the free diffusion of substances between the circulating blood and the neural tissues, blood-tissue barrier efficiently supplies nutrients to the retina and brain and removes endobiotics and xenobiotics from the neural tissues to maintain a constant milieu. We investigate transport mechanism at the blood-tissue barrier, especially blood-retinal barrier to develop strategies aimed at drug deliver to the retina.