大貫 義則 (客員教授) | 製剤設計学講座 | 富山大学

 

研究テーマ

  1. Bulletスキンクリーム中の水分子の運動性の可視化と製剤安定性との関係

  2. Bullet光架橋型ポリアクリル酸ヒドロゲルのゲル形成機構の解明

  3. Bullet親水性高分子マトリックス製剤からの薬物放出機構の解明

  4. Bulletフェニトイン注射剤配合変化の機構解明

  5. Bulletマイクロドメイン構造を考慮した新規リポソーム製剤の開発


経歴

平成10年3月 星薬科大学 薬学部 卒業

平成12年3月 星薬科大学大学院 薬学研究科 薬学専攻 修士課程修了

平成12年4月 リンテック株式会社 入社

                   研究開発本部研究所 ヘルスケア製品研究室配属

平成14年7月 星薬科大学 薬剤学教室 助手として採用

平成19年4月 星薬科大学 薬剤学教室 助教

平成20年 University of Connecticut, School of Pharmacyにて博士研究員

平成21年 Johns Hopkins University, School of Medicineにて博士研究員 平成26年4月 星薬科大学 薬剤学教室 講師

平成26年1月 星薬科大学 薬剤学教室 准教授

平成27年4月 富山大学 薬学部 薬学科 製剤設計学講座 客員教授


取得資格

平成10年9月 薬剤師免許 取得

平成18年9月 博士(薬学) 取得

平成25年12月 第一種放射線取扱主任者

平成26年3月 エックス線作業主任者


研究業績

外部Webページ

Scopus

科研費


原著論文

  1. 1.Onuki, Y., Morishita, M., Takayama, K., Tokiwa, S., Chiba, Y., Isowa, K., Nagai, T., In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption. Int. J. Pharm., 198, 147-156 (2000).

  2. 2.Onuki, Y., Morishita, M., Watanabe, H., Chiba, Y., Tokiwa, S., Takayama, K., Nagai, T., Improved insulin enteral delivery using water-in-oil-in-water multiple emulsion incorporating highly purifuled docosahexaenoic acid. S.T.P. Pharma Sci., 13, 231-235 (2003).

  3. 3.Onuki, Y., Morishita, M., Takayama, K., Formulation optimization of water-in-oil-in-water multiple emulsion for intesitinal insulin delivery. J. Control. Release, 97, 91-100 (2004).

  4. 4.Onuki, Y., Hoshi, M., Okabe, H., Fujikawa, M., Morishita, M., Takayama, K., Formulation optimization of photocrosslinked polyacrylic acid modified with 2-hydroxyethyl methacrylate hydrogel as an adhesive for a dermatological patch. J. Control. Release, 108, 331-340 (2005).

  5. 5.Yanagawa, F., Onuki, Y., Morishita, M., Takayama, K., Involvement of fractal geometry on solute permeation through porous poly (2-hydroxyethyl methacrylate) membranes. J Control. Release, 110, 395-399 (2006).

  6. 6.Onuki, Y., Morishita, M., Chiba, Y., Tokiwa, S., Takayama, K., Docosahexaenoic acid and eicosapentaenoic acid induce changes in the physical properties of a lipid bilayer model membrane. Chem. Pharm. Bull., 54, 68-71 (2006).

  7. 7.Miyazaki Y., Onuki Y.,  Yakou S., Takayama K., Effect of temperature-increase rate on drug release characteristics of dextran microspheres prepared by emulsion solvent evaporation process, Int. J. Pharm., 324, 144-151 (2006).

  8. 8.Khafagy ES., Morishita M., Onuki Y., Takayama K.., Current challenges in non-invasive insulin delivery systems: A comparative review, Adv. Drug Deliv. Rev., 59, 1521-1546 (2007).

  9. 9.Onuki Y., Nishikawa M., Morishita M., Takayama K.., Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: Involvement of formulation factors in physical properties and pharmacological effects, Int. J. Pharm., 349, 47-52 (2008).

  10. 10.Onuki Y., Ohyama K., Kaseda C., Arai H., Suzuki T., Takayama K., Evaluation of the reliability of nonlinear optimal solutions in pharmaceuticals using a bootstrap resampling technique in combination with Kohonen's self-organizing maps, J. Pharm. Sci., 97, 331-339 (2008).

  11. 11.Nakamura, K., Morishita, M., Ehara, J., Onuki, Y., Yamagata, T., Kamei, N., Lowman, A.M., Peppas, N.A., Takayama, K., Key functions in polymer carriers for intestinal absorption of insulin, Int. J. Pharm., 354, 135-142 (2008).

  12. 12.Yanagawa, F., Ishii, Y., Onuki, Y., Morishita, M., Takayama, K., Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices, Colloids Surf. B Biointerfaces, 63 (2008) 146-152.

  13. 13.Onuki, Y., Hagiwara, C., Sugibayashi, K., Takayama, K., Specific effect of polyunsaturated fatty acids on the cholesterol-poor membrane domain in a model membrane, Chem. Pharm. Bull., 56 (2008) 1103-1109.

  14. 14.Nishikawa, M., Onuki, Y., Isowa, K., Takayama, K., Formulation optimization of an indomethacin-containing photocrosslinked polyacrylic acid hydrogel as an anti-inflammatory patch, AAPS Pharm. Sci. Tech., 9 (2008) 1038-1045.

  15. 15.Onuki, Y., Bhardwaj, U.,  Papadimitrakopoulos, F., Burgess,  D.J., Biocompatibility of implantable devices: Current challenges to overcome foreign body response, J. Diabetes Sci. Technol., 2 (2008) 1003-1015.

  16. 16.Sugibayashi, K., Onuki, Y., Takayama, K., Displacement of tight junction proteins from detergent resistant membrane domains by treatment with sodium caprate, Eur. J. Pharm. Sci., 36 (2009) 246-253.

  17. 17.Yanagawa, F., Onuki, Y., Morishita, M., Takayama, K., Prediction of permeability of FD-4 through porous poly (2-hydroxyethyl methacrylate) membrane by multiple linear regression and artificial neural network, Pharmazie, 64 (2009) 311-315.

  18. 18.Onuki, Y., Takayama, K., Phase behavior in a ternary lipid membrane estimated using a nonlinear response surface method and Kohonen’s self-organizing map. J. Colloid. Interf. Sci., 343 (2010) 628-633.

  19. 19.Nishikawa, M., Onuki, Y., Okuno, Y., Takayama, K., Improving rheological characteristics of hydrophilic ointment base by treatment with a high pressure wet-type jet mill, Drug Dev. Ind. Pharm., 36 (2010) 625-631.

  20. 20.Watanabe, H., Obata, Y., Onuki, Y., Ishida, K., Takayama, K., Novel preparation of intercellular lipid models of the stratum corneum containing steroactive ceramide, Chem. Pharm. Bull., 58 (2010) 312-317.

  21. 21.Yasuda, A., Onuki, Y., Kikuchi, S., Takayama, K., Self-organizing map analysis using multivariate data from theophylline powders predicted by a thin-plate spline interpolation, J. Pharm. Sci., 99 (2010) 4535-4542.

  22. 22.Onuki, Y., Jacobs, I., Artemov, D., Kato, Y., Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique, Biomaterials 31 (2010) 7132-7138.

  23. 23.Onuki, Y., Kikuchi, S., Yasuda, A., Takayama, K., Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method, Int. J. Pharm., 396 (2010) 75-82.

  24. 24.Watanabe, H., Obata, Y., Onuki, Y., Ishida, K., Takayama, K., Different effects of l- and d-menthol on the microstructure of the ceramide 5/cholesterol/palmitic acid bilayers, Int. J. Pharm., 402 (2010) 146-152.

  25. 25.Leong, K.H., Chung, L.Y., Noordin, M.I., Mohamad, K., Nishikawa, M., Onuki, Y., Morishita, M., Takayama, K., Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules, Carbohyd. polym., 83 (2011) 1507-1515.

  26. 26.Kikuchi, S, Onuki, Y., Yasuda, A., Hayashi, Y., Takayama, K.,  Latent Structure Analysis in Pharmaceutical Formulations Using Kohonen’s Self-organizing Map and a Bayesian Network, J. Pharm. Sci., 100 (2011) 964-975.

  27. 27.Nishikawa, M., Onuki, Y., Okuno, Y., Takayama, K., Impact of state of water in skin cream base on its dispersion stability elucidated by magnetic resonance techniques, Chem. Pharm. Bull., 59 (2011) 332-337 .

  28. 28.Arai, H., Suzuki, T., Yada, S., Kaseda, C., Onuki, Y., Takayama, K., Reliability evaluation of the design space of the granulation process of mefenamic acid tablets using a bootstrap resampling technique, Chem. Pharm. Bull., 59 (2011) 608-617.

  29. 29.Leong, K.H., Chung, L.Y., Noordin, M.I., Onuki, Y., Morishita, M., Takayama, K., Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery,  Carbohyd. polym., 86 (2011) 555-565.

  30. 30.Norioka, T., Kikuchi, S., Onuki, Y., Takayama, K., Imai, K., Optimization of the manufacturing process for oral formulations using multivariate statistical methods, J. Pharm. Innov., 6 (2011) 157-169.

  31. 31.Hayashi, Y., Kikuchi, S., Onuki, Y., Takayama, K., Reliability evaluation of nonlinear design space in pharmaceutical product development, J. Pharm. Sci., 101 (2012) 333-341.

  32. 32.Onuki, Y., Ikegami-Kawai, M., Ishitsuka, K., Hayashi, Y., Takayama, K., A 5% glucose infusion fluid provokes significant precipitation of phenytoin sodium injection via interruption of the cosolvent effect of propylene glycol., Chem. Pharm. Bull, 60 (2012) 86-93.

  33. 33.Kikuchi, S., Onuki, Y., Kuribayashi, H., Takayama, K., Relationship between diffusivity of water molecules inside hydrating tablets and their drug release behavior elucidated by magnetic resonance imaging, Chem. Pharm. Bull, 60 (2012) 536-542.

  34. 34.Onuki, Y., Kawai, S., Arai, H., Maeda, J., Takagaki, K., Takayama, K., Contribution of the physicochemical properties of active pharmaceutical ingredients to tablet properties identified by ensemble artificial neural networks and Kohonen's self-organizing maps, J. Pharm. Sci, 101 (2012) 2372-2381.

  35. 35.Duangjit, S., Obata, Y., Sano, H., Onuki, Y., Opanasopit, P., Ngawhirunpat, T., Maitani, Y., Takayama, K., Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: Optimization and characterization, Bio. Pharm. Bull, 35 (2012) 1720-1728.

  36. 36.Ishitsuka, K., Onuki, Y., Takayama, K., Change in the drug release behavior of theophylline sustained-release tablets after division into two halves, Yakugaku Zasshi 132 (2012) 225-230.

  37. 37.Hayashi, Y., Oshima, E., Maeda, J., Onuki, Y., Obata, Y., Takayama, K., Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet, Chem. Pharm Bull, 60 (2012) 1419-1425.

  38. 38.Norioka, T., Hayashi, Y., Onuki, Y., Andou, H., Tsunashima, D., Yamashita, K., Takayama, K., A Novel approach to establishing the design space for oral formulation manufacturing process, Chem. Pharm. Bull 61 (2013) 39-49.

  39. 39.Yasuda, A., Onuki, Y., Obata, Y, Yamamoto, R., Takayama, K., Self-organizing map analysis using multivariate data from theophylline tablets predicted by a thin-plate spline interpolation, Chem. Pharm. Bull., 61 (2013) 304-309.

  40. 40.Hayashi, Y., Miura, T., Shimada, T., Onuki. Y., Obata, Y., Takayama, K., Prediction of tablet characteristics from residual stress distribution estimated by finite element method, J. Pharm Sci., 102 (2013) 3678-3686.

  41. 41.Kamei, N., Onuki, Y., Takayama, K., Takeda-Morishita, M., Mechanistic study of the uptake/permeation of cell-penetrating peptides across a Caco-2 monolayer and their stimulatory effect on epithelial insulin transport, J. Pharm. Sci., 102 (2013) 3998-4008.

  42. 42.Duangjit S, Obata Y, Sano H, Onuki Y, Opanasopit P, Ngawhirunpat T, Miyoshi T, Kato S, Takayama K., Comparative study of novel ultradeformable liposomes: menthosomes, transfersomes and liposomes for enhancing skin permeation of meloxicam, Biol Pharm Bull. 37 (2014) 239-247.

  43. 43.Yamamoto Y, Fukami T, Koide T, Onuki Y, Suzuki T, Metori K, Katori N, Hiyama Y, Tomono K., Comparative pharmaceutical evaluation of brand and generic clobetasone butyrate ointments, Int J Pharm. 463 (2014) 62-67.

  44. 44.Onuki, Y., Horita, A., Kuribayashi, H., Okuno, Y., Obata, Y., Takayama, K., Nondestructive monitoring of creaming of oil-in-water emulsion-based formulations using magnetic resonance imaging,  Drug Dev. Ind. Pharm., 40 (2014) 937-943.

  45. 45.Yasuda, A., Onuki, Y., Obata, Y., Takayama, K., Latent structure modeling underlying theophylline tablet formulations using a Bayesian network based on a self-organizing map clustering, Drug Dev. Ind. Pharm., (2014) in press

  46. 46.Onuki, Y., Hasegawa, N., Ikegami-Kawai, M., Suematsu, T., Sakurai, S., Shirozu, S., Tsubuki, M., Obata, Y., Takayama, K., Contribution of glucose to crystallization of phenytoin in injectable dosage form by dilution with infusion fluids, Chem. Pharm. Bull., 62 (2014) 989-993.

  47. 47.Hayashi, Y., Otoguro, S., Miura, T., Onuki, Y., Obata, Y., Takayama, K., Effect of process variables on the DPC model and residual stress distribution of tablets estimated by the finite element method, Chem. Pharm. Bull., 62 (2014) 1062-1072.

  48. 48.Onuki, Y., Hasegawa, N., Kida, C., Obata, Y., Takayama, K., Study of the contribution of the state of water to the gel properties of a photocrosslinked polyacrylic acid hydrogel using magnetic resonance imaging,  J. Pharm. Sci. 103 (2014) 3532-3541.

  49. 49.K. Ishida, K., Obata, Y., Akagi, C., Onuki, Y., Takayama, K., Practical syntheses of D-erythro- and L-threo-ceramide [NDS] and difference in contribution of each isomer in microstructure, J Drug Del Sci Tech, 24 (2014) 689-693.

  50. 50.Onuki, Y., Hasegawa, N., Kida, C., Ikegami-Kawai, M., Tsubuki, M., Shirozu, S., Obata, Y., Takayama, K.,  Supersaturated state of diazepam injection following dilution with infusion fluid, J. Pharm. Health Car. Sci., 1 (2015) 9.

  51. 51.Yamamoto, Y., Fukami, T., Koide, T., Onuki, Y., Suzuki, T., Katori, N., Tomono, K., Studies on the uniformity of the active ingredients in acetaminophen suppositories that were re-solidified after melting under high temperature conditions, Chem. Pharm. Bull., 63 (2015) 263-272.

  52. 52.Onuki, Y., Funatani, C., Yokawa, T., Yamamoto, Y., Fukami, T., Koide, T., Obata, Y., Takayama, K., Magnetic resonance imaging of the phase separation in mixed preparations of moisturizing cream and steroid ointment after centrifugation, Chem. Pharm. Bull.,  63 (2015) 377-383.

  53. 53.Onuki, Y., Machida, Y., Yokawa, T., Seike, C., Sakurai, S., Takayama, K., Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus, Chem. Pharm. Bull., 63 (2015) 457-462.

  54. 54.Inoue, Y., Iwazaki, Y., Onuki, Y., Funatani, C., Murata, I., Kanamoto, I., Examination of gelling agents to produce acetaminophen jelly, Chem Pharm Bull, 63 (2015) 519-524.

  55. 55.Onuki Y, Hasegawa N, Horita A, Ueno N, Kida C, Hayashi Y, Obata Y, Takayama K. Self-organizing Map Analysis for Understanding Comprehensive Relationships between Formulation Variables, State of Water, and the Physical Stability of Pharmaceutical Emulsions. Chem Pharm Bull. 63(2015) 901-6.

  56. 56.Otoguro S, Hayashi Y, Miura T, Uehara N, Utsumi S, Onuki Y, Obata Y, Takayama K. Numerical Investigation of the Residual Stress Distribution of Flat-Faced and Convexly Curved Tablets Using the Finite Element Method. Chem Pharm Bull. 63 (2015) 890-900.

  57. 57.Uehara N, Hayashi Y, Mochida H, Otoguro S, Onuki Y, Obata Y, Takayama K. Latent structure analysis in the pharmaceutical process of tablets prepared by wet granulation. Drug Dev Ind Pharm. 42 (2015) 116-122.

  58. 58.Onuki Y, Obata Y, Kawano K, Sano H, Matsumoto R, Hayashi Y, Takayama K. Membrane Microdomain Structures of Liposomes and Their Contribution to the Cellular Uptake Efficiency into HeLa Cells. Mol Pharm. 13 (2016) 369–378.

以降は研究業績をご覧ください。



総説

  1. 1.Khafagy ES., Morishita M., Onuki Y., Takayama K., Current challenges in non-invasive insulin delivery systems: A comparative review, Adv. Drug Deliv. Rev., 59 (2007) 1521-1546.

  2. 2.Onuki, Y., Bhardwaj, U., Papadimitrakopoulos, F., Burgess, D.J., Biocompatibility of implantable devices: Current challenges to overcome foreign body response, J. Diabetes Sci. Technol., 2 (2008) 1003-1015.


著書

  1. 1.大貫義則,岡部秀晃,医療用「貼付剤」の構成とその特徴,Pharm. Tech. Japan,20, 127-132(2004)

  2. 2.大貫義則, 森下真莉子, 髙山幸三, Water-in- oil-in-water形複合エマルションを用いたインスリン消化管粘膜吸収製剤の開発, 製剤機械技術研究会誌, 17 (2008) 19-25.

  3. 3.大貫義則, 森下真莉子, 髙山幸三, 血糖低下作用と製剤安定性を兼ね備えたwater-in- oil-in-water形複合エマルション製剤の処方最適化検討, 製剤機械技術研究会誌, 17 (2008) 26-33.

  4. 4.大貫義則 (分担執筆), ゲルの安定化と機能性付与・次世代への応用開発, 技術情報協会, 2013


特許等

1.消臭抗菌シートおよび消臭抗菌袋:大貫義則ほか, 実用新案出願2002-363

2.ハイドロゲル基剤,パップ基剤,パップ剤及び水性ゲルシート:大貫義則,高山幸三,高梨誉也,星 優,特願2005-021555.


受賞歴

2007年9月 APSTJ Global Education Seminar Presentation Award

2011年5月 平成23年度大谷記念研究助成


学術雑誌編集委員

BioMed Research International  (2013〜)

オオヌキ  ヨシノリ
大貫 義則

客員教授

薬学博士

富山大学大学院医学薬学研究部(薬学) 製剤設計学講座 〒930−0194 富山県富山市杉谷2630 薬学部研究棟(U3) 6F

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