業績

リスト中の●は、当研究室が主体となって行ったものを示す

[2025-]

●Numata Y, Fujii T, Toda C, Okumura T, Manabe T, Takeda N, Shimizu T, Tabuchi Y, Fujii T, Sakai H. (2025)
Digoxin promotes anoikis of circulating cancer cells by targeting Na⁺/K⁺-ATPase α3-isoform.
Cell Death Dis. 16(1): 373.

●Kageyama T, Shimizu T, Shirai K, Nabeshima S, Ozawa S, Fujii T, Yonekawa Y, Sakai H. (2025)
Ion channel function of human TMEM16F is associated with phospholipid transport through its subunit cavity.
Biol Pharm Bull. 48(5): 595-605.

[2024-2020]

●Katoh M, Fujii T, Tabuchi Y, Shimizu  T, Sakai H. (2024)
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.
J Physiol Sci. 74(1): 23.

●藤井 拓人, 清水 貴浩, 酒井 秀紀．（2023）
がん細胞におけるNa⁺/K⁺ポンプとCl^-チャネルの新しい病態生理機能
日本薬理学雑誌　158 巻6 号 p. 465-468.

●Fujii T, Nagamori S, Wiriyasermkul P, Zheng S, Yago A, Shimizu T, Tabuchi Y, Okumura T, Fujii T, Takeshima H, Sakai H. (2023)
Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H⁺,K⁺-ATPase.
Nat Commun. 14(1): 2174.

●Fujii T,Shimizu T. Kaji Y, Katoh M, Sakai H. (2023)
Activation of mouse Otop3 proton channels by Zn²⁺.
Biochem Biophys Res Commun. 658: 55~61.

●Shimizu T, Fujii T, Hanita K, Shinozaki R, Takamura Y, Suzuki Y, Kageyama T, Kato M, Nishijo H, Tominaga M, Sakai H. (2023)
Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine.
Sci Rep. 13(1): 4271.

●Fujii T, Katoh M, Ootsubo M, Nguyen OTT, Iguchi M, Shimizu T, Tabuchi Y, Shimizu Y, Takeshima H, Sakai H. (2022)
Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na⁺ ,K⁺ -ATPase α3-isoform in human cancer cells.
J Cell Physiol. 237(7): 2980-2991.

●Shimizu T, Yanase N, Fujii T, Sakakibara H, Sakai H. (2022)
Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin
Biochim Biophys Acta Biomembr. 1864(1): 183782.

●藤井 拓人．（2021）
膜分布の違いが生み出すP型イオンポンプ機能の多様な分子機構
Yakugaku Zasshi　141 巻11 号 p. 1217-1222.

Okada T, Wu N, Takashima K, Ishimura J, Morita H, Ito T, Kodama T, Yamasaki Y, Akanuma SI, Kubo Y, Hosoya KI, Tsuneki H, Wada T, Sasaoka T, Shimizu T, Sakai H, Dwoskin LP, Hussaini SR, Saporito RA, Toyooka N. (2021)
Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent- cis-195A and cis-211A
Molecules. 26(24): 7529.

●Fujii T, Sugimoto K, Noda T, Shimizu T, Matsuya Y, Sakai H. (2021)
Inhibition of gastric H⁺,K⁺-ATPase by new dihydropyrazole derivative KYY-008
Biochem Biophys Res Commun. 567: 177-182.

●Fujii T, Shimizu T, Katoh M, Nagamori S, Koizumi K, Fukuoka J, Tabuchi Y, Sawaguchi A, Okumura T, Shibuya K, Fujii T, Takeshima H, Sakai H. (2021)
Survival of detached cancer cells is regulated by movement of intracellular Na⁺,K⁺-ATPase.
iScience. 24(5): 102412.

●Shimizu T, Fujii T, Sakai H. (2020)
The Relationship Between Actin Cytoskeleton and Membrane Transporters in Cisplatin Resistance of Cancer Cells.
Front Cell Dev Biol. 8: 597835.

●Shimizu T, Fujii T, Ohtake H, Tomii T, Takahashi R, Kawashima K, Sakai H. (2020)
Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume-sensitive Cl^- channels in human epidermoid carcinoma cells.
J Cell Physiol. 235(12): 9589-9600.

●Kawai S, Fujii T, Shimizu T, Sukegawa K, Hashimoto I, Okumura T, Nagata T, Sakai H, Fujii T. (2020)
Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells.
J Physiol Sci. 70(1): 15.

[2019-2015]　

●藤井 拓人, 清水 貴浩, 竹島 浩, 酒井 秀紀．（2019）
ナトリウムポンプと細胞容積調節性アニオンチャネルのがん細胞特異的な機能連関
日本薬理学会誌 　154 巻 3 号 p. 103-107.

●藤井 拓人, 清水 貴浩, 久代 京一郎, 竹島 浩, 高井 まどか, 酒井 秀紀．（2019）
シアル酸蛍光ナノプローブを用いた胃プロトンポンプのネガティブフィードバック機構の可視化
日本薬理学会誌　153 巻 6 号 p. 261-266.

Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ,
Edwards C, Ivanov AP, Klenerman D, Sviderskaya EV, Edel JB, Korchev Y. (2019)
High-resolution label-free 3D mapping of extracellular pH of single living cells.
Nat Commun. 10: 5610.

●Fujii T, Phutthatiraphap S, Shimizu T, Takeshima H, Sakai H. (2019)
Non-morphogenic effect of Sonic Hedgehog on gastric H⁺,K⁺-ATPase activity.
Biochem Biophys Res Commun. 518: 605-609.

Okada Y, Okada T, Sato-Numata K, Islam R, Ando-Akatsuka Y, Numata T, Kubo M, Shimizu T, Kurbannazarova R, Marunaka Y, Sabirov R. (2019)
Cell volume-activated and -correlated anion channels in mammalian cells: Their biophysical, molecular and pharmacological properties.
Pharmacol Rev 71: 49-88.

●Fujii T, Shimizu T, Yamamoto S, Funayama K, Fujita K, Tabuchi Y, Ikari A, Takeshima H, Sakai H. (2018)
Crosstalk between Na⁺,K⁺-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells.
Biochim Biophs Acta Mol Basis Dis 1864: 3792-3804.

●Phutthatiraphap S, Hayashi Y, Fujii T, Kosugi A, Okada K, Kadozaki T, Ishise T, Sakai H, Onuki Y. (2018)
Inhibition of gastric H⁺,K⁺-ATPase activity in vitro by dissolution media of original brand-name and generic tablets of Lansoprazole, a proton pump inhibitor.
Chem Pharm Bull 66: 896-900.

Maruhashi R, Akizuki R, Sato T, Matsunaga T, Endo S, Yamaguchi M, Yamazaki Y, Sakai H, Ikari A. (2018)
Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models.
Biochim Biophys Acta Mol Cell Res 1865: 470-479.

Miyazaki Y, Ichimura A, Sato S, Fujii T, Oishi S, Sakai H, Takeshima H. (2018)
The natural flavonoid myricetin inhibits gastric H⁺,K⁺-ATPase.
Eur J Pharmacol. 820: 217-221.

Hibino H, Takai M, Noguchi H, Sawamura S, Takahashi Y, Sakai H, Shiku H. (2017)
An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution.
J Physiol Sci. 67: 439-445.

●Shimizu T, Higuchi T, Toba T, Ohno C, Fujii T, Nilius B, Sakai H. (2017)
The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation.
FEBS Open Bio 7: 1392-1401.

●Fujii T, Watanabe M, Shimizu T, Takeshima H, Kushiro K, Takai M, Sakai H. (2016)
Positive regulation of the enzymatic activity of gastric H⁺,K⁺-ATPase by sialylation of its β-subunit.
Biochemical Biophysical Acta 1858: 1228-1235.

Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A. (2016)
Hypotonic stress-induced down-regulation of claudin-1 and -2 mediated by dephosphorylation and clathrin-dependent endocytosis in renal tubular epithelial cells.
Journal of Biological Chemistry 291: 24787-24799.

●Fujii T, Takahashi Y, Takeshima H, Saitoh C, Shimizu T, Takeguchi N, Sakai H. (2015)
Inhibition of gastric H⁺,K⁺-ATPase by 4-(2-butyl-6,7-dichloro-2- cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel.
European Journal of Pharmacology  765: 34-41.

●Shimizu T, Ohtake H, Fujii T, Tabuchi Y, Sakai H. (2015)
Voltage-sensitive outwardly rectifying Cl^- channels contribute to butyrate-triggered apoptosis of murine colonic epithelial MCE301 cells.
Journal of Physiological Sciences  65: 151-157.

Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H, Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J. (2015)
Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.
Biochemical Biophysical Acta 1848: 2326-2336.

[2014-2010]　

●Higuchi T, Shimizu T, Fujii T, Nilius B, Sakai H. (2014)
Gating modulation by heat of the polycystin transient receptor potential channel PKD2L1 (TRPP3).
Pflugers Archiv European Journal of Physiology 466: 1933-1940.

●Takahashi Y, Fujii T, Fujita K, Shimizu T, Higuchi T, Tabuchi Y, Sakamoto H, Naito I, Manabe K, Uchida S, Sasaki S, Ikari A, Tsukada K, Sakai H. (2014)
Functional coupling of chloride-proton exchanger ClC-5 to gastric H⁺,K⁺-ATPase
Biology Open 3: 12-21.

●Shimizu T, Fujii T, Takahashi Y, Takahashi Y, Suzuki T, Ukai M, Tauchi K, Horikawa N, Tsukada K, Sakai H. (2014)
Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation.
Pflugers Archiv European Journal of Physiology 466: 541-548.

Ikari A, Tonegawa C, Sanada A, Kimura T, Sakai H, Hayashi H, Hasegawa H, Yamaguchi M, Yamazaki Y, Endo S, Mtsunaga T, Sugatani J. (2014)
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
Journal of Biological Chemistry 289: 13112-13123.

●Fujii T, Awaka SY, Takahashi Y, Fujita K, Tsuji H, Shimizu T, Gomi T, Tsukada K, Sakai H. (2013)
Modulation of H⁺,K⁺-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells.
FEBS Letters 587: 3898-905.

●Shimizu T, Iehara T, Sato K, Fujii T, Sakai H, Okada Y. (2013)
TMEM16F is a component of a Ca²⁺-activated Cl^- channel but not a volume-sensitive outwardly rectifying Cl^- channel.
American Journal of Physiology Cell Physiology 304: C748-C759.

Ikari A, Atomi K, Yamazaki Y, Sakai H, Hayashi H, Yamaguchi M, Sugatani J. (2013)
Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
Biochemical Biophysical Acta 1833: 2617-2627.

●Fujita K, Fujii T, Shimizu T, Takeguchi N, Sakai H. (2012)
Role of cholesterol in functional association between K⁺-Cl^- cotransporter-3a and Na⁺,K⁺-ATPase.
Biochemical and Biophysical Research Communication 424: 136-140

●Fujii T, Minagawa T, Shimizu T, Takeguchi N, Sakai H. (2012)
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.

Journal of Physiological Sciences 62: 53-58.

Nishi M, Aoyama F, Kisa F, Zhu H, Sun M, Lin P, Ohta H, Van B, Yamamoto S, Kakizawa S, Sakai H, Ma J, Sawaguchi A, Takeshima H. (2012)
TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.
Journal of Biological Chemistry 287: 33523-33532.

Wang X, Tsuneki H, Urata N, Tezuka Y, Wada T, Sasaoka, Sakai H, Saporito RA, Toyooka N. (2012)
Synthesis and biological activities of the 3,5-disubstituted indolizidine poison frog alkaloid 239Q and its congeners.
European Journal of Organic Chemistry 36: 7082-7092.

Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y. (2012)
Involvements of the ABC protein ABCF2 and a-actinin-4 in regulation of cell volume and anion channels in human epithelial cells.
Journal of Cellular Physiology 227: 3498-3510.

Hasegawa Y, Shimizu T, Takahashi N, Okada Y. (2012)
The apoptotic volume decrease is an upstream event of MAP kinase activation during staurosporine-induced apoptosis in HeLa cells.
International Journal of Molecular Sciences 13: 9363-9379.

 

●Shimizu T, Higuchi T, Fujii T, Nilius B, Sakai H. (2011)
Bimodal effect of alkalization on the polycystin transient receptor potential channel, PKD2L1.

Pflugers Archiv European Journal of Physiology 461: 507-513.

 

●Fujii T, Takeguchi N, Sakai H. (2011)
]Function of K⁺-Cl^- cotransporters in the acid secretory mechanism of gastric parietal cells.

Biological and Pharmaceutical Bulletin 34: 810-812.

 

●Shibuya K, Fukuoka J, Fujii T, Shimoda E, Shimizu T, Sakai H, Tsukada K. (2010)
Increase in ouabain-sensitive K⁺-ATPase activity in hepatocellular carcinoma by overexpression of Na⁺,K⁺-ATPase α3-isoform.

European Journal of Pharmacology, 638: 42-46.

 

●Fujii T, Fujita K, Shimizu T, Takeguchi N, Sakai H. (2010)
The NH₂-terminus of K⁺-Cl^- cotransporter 3a is essential for up-regulation of Na⁺,K⁺-ATPase activity.

Biochemical and Biophysical Research Communication 399: 683-687.

 

●Shimizu T. (2010)
A new player in apoptosis triggered with anti-cancer drugs: the volume-sensitive outwardly-rectifying Cl^- channel.

Cancer Biology and Therapy 9: 1-3.

[2009-2005] 

●Fujii T, Takahashi Y, Ikari A, MoriiM, Tabuchi Y, Tsukada K, Takeguchi N, Sakai H. (2009)
Functional association between K⁺-Cl^- cotransporter-4 and H⁺,K⁺-ATPase in the apical canalicularmembrane of gastric parietal cells.
Journal of Biological Chemistry 284: 619-629.

 

●Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, Morii M, Takeguchi N, Tsukada K, Sakai H. (2009)
Involvement of aquaporin-5 in differentiation of human gastric cancer cells.
Journal of Physiological Sciences 59: 113-122

 

Shimizu T, Janssens A, Voets T, Nilius B. (2009)
Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume.

Pflugers Archiv European Journal of Physiology 457: 795-807.

 

Shimizu T, Owsianik G, Freichel M, Flockerzi V, Nilius B, Vennekens R. (2009)
TRPM4 regulates migration of mast cells in mice.

Cell Calcium 45: 226-232.

 

Liu HT, Akita T, Shimizu T, Sabirov RZ, Okada Y. (2009)
Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels.

Journal of Physiology (London) 587: 2197-2209.

 

Zhou D, Toyooka N, Nemoto H, Yamaguchi K, Tsuneki H, Wada T, Sasaoka T, Sakai H, Tezuka Y, Kadota S, Jones TH, Garraffo HM, Spande TF, Daly JW. (2009)
Syntheses, determination of the absolute stereochemistry, and evaluations at the nicotinic acetylcholine receptors of a hydroxyindolizine alkaloid from the ant Myrmicaria melanogaster.

Heterocycles 79: 565-571.  

 

●Morii M, Yamauchi M, Ichikawa T, Fujii T, Takahashi Y, Asano S, Takeguchi N, Sakai H. (2008)
Involvement of the H3O⁺-Lys-164-Gln-161-Glu-345 charge transfer pathway in proton transport of gastric H⁺,K⁺-ATPase.

Journal of Biological Chemistry 283: 16876-16884.

 

●Fujii T, Takahashi Y, Itomi Y, Fujita K, Morii M, Tabuchi Y, Asano S, Tsukada K, Takeguchi N, Sakai H. (2008)
K⁺-Cl^- cotransporter-3a up-regulates Na⁺,K⁺-ATPase in lipid rafts of gastric luminal parietal cells.

Journal of Biological Chemistry 283: 6869-6877.

 

Eguchi H, Morii M, Takahashi Y, Sakai H, Nakano M, Ochiai H, Shirahata A, Hara Y, Kawamura M, Takeda K. (2008)
Functional consequences of various leucine mutations in the M3/M4 loop of the Na⁺,K⁺-ATPase α-subunit.

Journal of Membrane Biology 221: 133-140.

 

Ikari A, Ito M, Okude C, Sawada H, Harada H, Degawa M, Sakai H, Takahashi T, Sugatani J, Miwa M. (2008)
Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway.

Journal of Cellular Physiology 214: 221-229.

 

Toyooka N, Zhou D, Kobayashi S, Tsuneki H, Wada T, Sakai H, Nemoto H, Sasaoka T, Tezuka Y, Subehan, Kadota S, Garraffo HM, Spande TF, Daly JW (2008)
Syntheses of the proposed structures of poison-frog alkaloids 179 and 207E and their inhibitory effects on neuronal nicotinic acetylcholine receptors.

Synlett 1: 61-64.

 

●Fujii T, Ohira Y, Itomi Y, Takahashi Y, Asano S, Morii M, Takeguchi N, Sakai H. (2007)
Inhibition of P-type ATPases by [(dihydroindenyl)oxy]acetic acid (DIOA), a K⁺-Cl^- cotransporter inhibitor.

European Journal of Pharmacology 560: 123-126.

 

Asano S, Kameyama M, Oura A, Morisato A, Sakai H, Tabuchi Y, Chairoungdua A, Endou H, Kanai Y. (2007)
L-type amino acid transporter-1 expressed in human astrocytomas, U343MGa.

Biological and Pharmaceutical Bulletin 30: 415-422.

 

Toyooka N, Kobayashi S, Zhou D, Tsuneki H, Wada T, Sakai H, Nemoto H, Sasaoka T, Garraffo HM, Spande TF, Daly JW. (2007)
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.

Bioorganic and Medicinal Chemistry Letters 17: 5872-5875.

 

Kobayashi S, Toyooka N, Zhou D, Tsuneki H, Wada T, Sasaoka T, Sakai H, Nemoto H, Garraffo HM, Spande TF, Daly JW. (2007)
Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B'', (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.

Beilstein Journal of Organic Chemistry 3: 30.

 

●Sakai H, Suzuki T, Takahashi Y, Ukai M, Tauchi K, Fujii T, Horikawa N, Minamimura T, Tabuchi Y, Morii M, Tsukada K, Takeguchi N. (2006)
Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A₂.

FEBS Letters 580: 3368-3374.

 

Tabuchi Y, Kuribayashi R, Takasaki I, Doi T, Sakai H, Takeguchi N, Kondo T, Ohtsuka K. (2006)
Overexpression of Hsp70 partially restores the structural stability and functional defects of temperature-sensitive mutant of large T-antigen at nonpermissive temperature.

Cell Stress and Chaperones 11: 259-267.

 

Tabuchi Y, Takasaki I, Doi T, Ishii Y, Sakai H, Kondo T. (2006)
Genetic networks responsive to sodium butyrate in colonic epithelial cells.

FEBS Letters 580: 3035-3041.

 

●Horikawa N, Suzuki T, Uchiumi T, Minamimura T, Tsukada K, Takeguchi N, Sakai H. (2005)
Cyclic AMP-dependent Cl^- secretion induced by thromboxane A₂ in isolated human colon.

Journal of Physiology ( London ) 562: 885-897.

 

●Morii M, Sakai H, Takeguchi N. (2005)
Novel molecular mechanisms of gastric phospholipids translocation activity in isolated hog gastric vesicles.

Membrane 30: 312-317.

[2004-2000]

● Sakai H, Uchiumi T, Lee J-B, Ohira Y, Ohkura J-i, Suzuki T, Hayashi T, Takeguchi N. (2004)
Leukotrienes-mediated effects of water extracts from Sargassum horneri, a marine brown alga, on Cl^- absorption in isolated rat colon.

Japanese Journal of Physiology 54: 71-77.

 

●Sakai H, Suzuki T, Maeda M, Takahashi Y, Horikawa N, Minamimura T, Tsukada K, Takeguchi N. (2004)
Up-regulation of Na⁺,K⁺-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer.

FEBS Letters 563: 151-154.

 

●Hori K, Takahashi Y, Horikawa N, Furukawa T, Tsukada K, Takeguchi N, Sakai H. (2004)
Is the ClC-2 chloride channel involved in the Cl^- secretory mechanism of gastric parietal cells?

FEBS Letters 575:105-108.

 

Ikari A, Hirai N, Shiroma M, Harada H, Sakai H, Hayashi H, Suzuki Y, Degawa M, Takagi K. (2004)
Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells.

Journal of Biological Chemistry 279:54826-54832.

 

●Sakai H, Ohira Y, Tanaka A, Suzuki T, Ikari A, Morii M, Takeguchi N. (2003)
Inhibition of small-conductance Cl^- channels by the interleukin-1β-stimulated production of superoxide in rabbit gastric parietal cells.

Journal of Physiology ( London ) 551: 207-217.

 

●Sakai H, Suzuki T, Murota M, Takahashi Y, Takeguchi N. (2002)
Nitric oxide-induced Cl^- secretion in isolated rat colon is mediated by the release of thromboxane A₂.

Journal of Physiology ( London ) 543: 261-271.

 

●Takahashi Y, Sakai H, Kuragari M, Suzuki T, Tauchi K, Minamimura T, Tsukada K, Asano S, Takeguchi N. (2002)
Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.

Japanese Journal of Physiology 52: 317-321.

 

●Sakai H, Suzuki T, Murota M, Oketani K, Uchiumi T, Murakami M, Takeguchi N. (2002)
E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl^- secretion induced by platelet-activating factor in isolated rat colon.

British Journal of Pharmacology 136: 383-390.

 

●Sakai H, Shimizu T, Hori K, Ikari A, Asano S, Takeguchi N. (2002)
Molecular and pharmacological properties of inwardly rectifying K⁺ channels of human lung cancer cells.

European Journal of Pharmacology 435: 125-133.

 

●Sakai H, Ukai M, Ikari A, Asano S, Takeguchi N. (2001)
Is rabbit CLCA1 related to the basolateral Ca²⁺-dependent Cl^- channel of gastric parietal cells?

Japanse Journal of Physiology 51: 121-125.

 

●Suzuki T, Sakai H, Ikari A, Takeguchi N. (2000)
Inhibition of thromboxane A₂-induced Cl^- secretion by antidiarrhea drug loperamide in isolated rat colon.

Journal of Pharmacology and Experimental Therapeutics 295: 233-238.

 

●Suzuki T, Sakai H, Takeguchi N. (2000)
Thromboxane A₂-mediated Cl^- secretion induced by platelet-activating factor in isolated rat colon.

European Journal of Pharmacology 400: 297-303.

 

Schaefer L, Sakai H, Mattei M-G, Lazdunski M, Lingueglia E. (2000)
Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na⁺ channel from human small intestine.

FEBS Letters 471: 205-210.

 

●Suzuki T, Sakai H, Ikari A, Takeguchi N. (2000)
Mobilization of intracellular Ca²⁺ by thromboxane A₂ does not affect Ca²⁺-activated K⁺ channels in rat colonic crypt cells.

Japanese Journal of Physiology 50: 389-393.

 

 

[1999-1995]

Sakai H, Lingueglia E, Champigny G, Mattei M-G, Lazdunski M. (1999)
Cloning and functional expression of a novel degenerin-like Na⁺ channel gene in mammals.

Journal of Physiology ( London ) 519: 323-333.

 

●Ikari A, Sakai H, Takeguchi N. (1999)
Thromboxane A₂ receptor linked with the Ca²⁺ pathway in rat colonic crypt cells.

Biochemical and Biophysical Research Communications 258: 708-712.

 

●Ikari A, Sakai H, Tanaka A, Ikeda A, Inoue K, Takeguchi N. (1999)
Prostaglandin E₂-activated housekeeping Cl^- channels in the basolateral membrane of rat gastric parietal cells.

Japanese Journal of Physiology 49: 365-372.

 

●Sakai H, Ikari A, Shimizu T, Sato T, Takeguchi N. (1998)
Cyclic GMP-dependent cytoprotection against ethanol-induced damage in rabbit isolated gastric parietal cells.

European Journal of Pharmacology 361: 109-117.

 

●Ikari A, Sakai H, Takeguchi N. (1998)
Protein kinase C-mediated up-regulation of Na⁺/Ca²⁺-exchanger in rat hepatocytes determined by a new Na⁺/Ca²⁺-exchanger inhibitor, KB-R7943.

European Journal of Pharmacology 360: 91-98.

 

Lingueglia E, de Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M. (1997)
A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells.

Journal of Biological Chemistry 272: 29778-29783.

 

●Sakai H, Sato T, Hamada N, Yasue M, Ikari A, Kakinoki B, Takeguchi N. (1997)
Thromboxane A₂, released by the anti-tumour drug irinotecan, is a novel stimulator of Cl^- secretion in isolated rat colon.

Journal of Physiology ( London ) 505: 133-144.

 

●Ikari A, Sakai H, Takeguchi N. (1997)
ATP, thapsigargin and cAMP increase Ca²⁺ in rat hepatocytes by activating three different Ca²⁺ influx pathways.

Japanese Journal of Physiology 47: 235-239.

 

●Sakai H, Ikari A, Kumano E, Takeguchi N. (1996)
A cyclic GMP-dependent housekeeping Cl^- channel in rabbit gastric parietal cells activated by a vasodilator ecabapide.

British Journal of Pharmacology 119: 1591-1599.

 

●Sakai H, Kakinoki B, Diener M, Takeguchi N. (1996)
Endogenous arachidonic acid inhibits hypotonically-activated Cl^- channels in isolated rat hepatocytes.

Japanese Journal of Physiology 46: 311-318.

 

●Sakai H, Tabuchi Y, Kakinoki B, Seike H, Kumagai S, Matsumoto C, Takeguchi N. (1995)
Ca²⁺-activated outward-rectifier K⁺ channels and histamine release by rat gastric enterochromaffin-like cells.

European Journal of Pharmacology 291: 153-158.

 

●Sakai H, Kumano E, Ikari A, Takeguchi N. (1995)
A gastric housekeeping Cl^- channel activated via prostaglandin EP3 receptor-mediated Ca²⁺/nitric oxide/cGMP pathway.

Journal of Biological Chemistry 270: 18781-18785.

 

●Sakai H, Takeguchi N. (1995)
GTP-binding protein-mediated production of superoxide anion in rabbit gastric parietal cells.

Japanese Journal of Physiology 45: 673-679.

 

Sakai H, Diener M, Gartmann V, Takeguchi N. (1995)
Eicosanoid-mediated Cl^- secretion induced by the antitumor drug, irinotecan (CPT-11), in the rat colon.

Naunyn-Schmiedeberg’s Archives of Pharmacology 351: 309-314.

 

 

[1994-1990]

●Sakai H, Takeguchi N. (1994)
A GTP-binding protein inhibits a gastric housekeeping chloride channel via intracellular production of superoxide.

Journal of Biological Chemistry 269: 23426-23430.

 

●Asano S, Arakawa S, Hirasawa M, Sakai H, Ohta M, Ohta K, Takeguchi N. (1994)
C-terminal topology of gastric H⁺,K⁺-ATPase.

Biochemical Journal 299: 59-64.

 

●Sakai H, Takeguchi N. (1993)
Small-conductance Cl^- channels in rabbit parietal cells activated by prostaglandin E₂ and inhibited by GTPγS.

Journal of Physiology ( London ) 461: 201-212.

 

●Sakai H, Okada Y, Morii M, Takeguchi N. (1992)
Arachidonic acid and prostaglandin E2 activate small-conductance Cl^- channels in the basolateral membrane of rabbit parietal cells.

Journal of Physiology ( London ) 448: 293-306.

 

●Takeguchi N, Yamanouchi T, Sakai H, Morii M. (1992)
New fluorescent probes E3810 and methoxy E3810 for determining distributions of the apical membrane and the acidic compartment of gastric acid secreting cells.

Japanese Journal of Physiology 42: 75-88.

 

Fujisaki H, Shibata H, Oketani K, Murakami M, Fujimoto M, Wakabayashi T, Yamatsu I, Yamaguchi M, Sakai H, Takeguchi N. (1991)
Inhibitions of acid secretion by E3810 and omeprazole, and their reversal by glutathione.

Biochemical Pharmacology 42: 321-328.

[1989]

● Sakai H, Okada Y, Morii M, Takeguchi N. (1989)
Anion and cation channels in the basolateral membrane of rabbit parietal cells.

Pflugers Archiv European Journal of Physiology 414: 185-192.