Contribute to the improvement of pharmaceutical quality by engineering evaluation and design of formulation

From the viewpoint of assuring the efficacy and safety of pharmaceuticals, it is essential to correctly evaluate the physical properties of the active pharmaceutical ingredients in pharmaceutics. In our laboratory, we are engaged in research on pharmaceutical engineering, which investigates drug formulations from an engineering aspect. In particular, we are researching the physical properties of active pharmaceutical ingredients using relaxation phenomena in nuclear magnetic resonance (NMR). Our previous studies demonstrated that T1 and T2 relaxation measurements using a low-field NMR system could evaluate crystalline state in solid dosage form and agglomeration of drug particles in nanosuspension. Bench-top low-field NMR system is specialized for relaxation measurements, which can be completed in a short time, and is expected to be applied to process analytical techniques in pharmaceutical manufacturing.