Strategies for Therapy of Retinal Diseases using Systemic Drug Delivery: Elucidating Blood-Retinal Transport Mechanism
The blood-tissue barriers including blood-retinal barrier form complex tight junctions of capillary endothelial cells and/or epithelial cells. Although these tight barriers prevent the free diffusion of substances between the circulating blood and the neural tissues, blood-tissue barrier efficiently supplies nutrients to the retina and brain and removes endobiotics and xenobiotics from the neural tissues to maintain a constant milieu. We investigate transport mechanism at the blood-tissue barrier, especially blood-retinal barrier to develop strategies aimed at drug deliver to the retina.
Research Topics
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Transport mechanisms for essential nutrients across the blood-retinal barrier
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Regulation mechanisms for transport system at the blood-retinal barrier
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Transport mechanisms for anionic compounds at the blood-retinal barrier
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Transport mechanisms for cationic drugs at the blood-retinal barrier
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Influx transport mechanism for nicotine at the blood-brain barrier
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Physiological role of the blood-brain barrier in regulating bioactive substances in brain
Lab Members
Ken-ichi Hosoya
Professor
- Degree
- Ph.D.
- Research Areas
- Blood-Retinal Barrier Transport, Molecular Pharmaceutics
Shin-ichi Akanuma
Associate Professor
- Degree
- Ph.D.
- Research Areas
- Blood-Brain Barrier, Transporter, Blood-retinal barrier
Yuma Tega
Assistant Professor
- Degree
- Ph.D.
- Research Areas
- Blood-Brain Barrier, Organic cation transport, Transporter