Realization of preemptive medicine aiming at the conquest of the diseases which exists no definitive therapy

Brain diseases which exists no definitive therapy has remained and development of innovative prevention and treatment methods are required. In addition, unpleasant abnormal sensations called “dysesthesia” (e.g. “pain”, “itch” and “numbness”) play an important role as a warning signal for the bioprotection. On the other hand, the dysesthesia caused by diseases and medications decreases quality of life and leads to be lower volition of fight against disease. In our laboratory, we are carrying out research focusing on prevention as well as treatment for overcoming brain diseases. Furthermore, to contribute to the therapy of the patients with severe dysesthesia, we are elucidating the mechanisms of dysesthesia and researching on new preventive and therapeutic medicines following the development of animal model of diseases with dysesthesia and the establishment of the evaluation methods.