1)   Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice.
Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Kon K, Hautala LC, Wang H, Wada T, Tsuneki H, Sasaoka T, Lehtonen S.
Int J Biol Sci. 18: 1852-1864, 2022.

2)   Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation.
Ito H, Kon K, Tsuneki H, Sasaoka T, Toyooka N, Yamazaki M.
PLoS One. 17:e0264386, 2022.

3)   Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity.
Tsuneki H, Maeda T, Takata S, Sugiyama M, Otsuka K, Ishizuka H, Onogi Y, Tokai E, Koshida C, Kon K, Takasaki I, Hamashima T, Sasahara M, Rudich A, Koya D, Sakurai T, Yanagisawa M, Yamanaka A, Wada T, Sasaoka T.
Cell Rep. 41:111497, 2022.

4)   Food odor perception promotes systemic lipid utilization.
Tsuneki H, Sugiyama M, Ito T, Sato K, Matsuda H, Onishi K, Yubune K, Matsuoka Y, Nagai S, Yamagishi T, Maeda T, Honda K, Okekawa A, Watanabe S, Yaku K, Okuzaki D, Otsubo R, Nomoto M, Inokuchi K, Nakagawa T, Wada T, Yasui T, Sasaoka T.
Nat Metab 4:1514-1531, 2022.

Review

1)   Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases.
Ikuko K, Kagawa S, Tsuneki H, Tanaka K, Nagashima F.
Pharmacol Ther. 235:108159, 2022.