2007

Original Papers

1)Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of α7 nicotinic receptors in isolated rat aortic smooth muscle cells.
Wada T, Naito M, Kenmochi H, Tsuneki H, Sasaoka T.
Endocrinology, 148: 790-799, 2007.

2)Novel G423S mutation of human α7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism.
Tsuneki H, Kobayashi S, Takagi K, Kagawa S, Tsunoda M, Murata M, Matsuoka T, Wada T, Kurachi M, Kimura I, Sasaoka T.
Mol Pharmacol, 71: 777-786, 2007.

3)Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells.
Tsuneki H, Sekizaki N, Suzuki T, Kobayashi S, Wada T, Okamoto T, Kimura I, Sasaoka T.
Eur J Pharmacol. 566:1-10, 2007.

4)Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms.
Yasuda M, Fukuchi M, Tabuchi A, Kawahara M, Tsuneki H, Azuma Y, Chiba Y, Tsuda M.
J Neurochem, 103: 626-636, 2007.

5)Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.
Toyooka N, Kobayashi S, Zhou D, Tsuneki H, Wada T, Sakai H, Nemoto H, Sasaoka T, Garraffo HM,
Spande TF, Daly JW.
Bioorg Med Chem Lett, 17: 5872-5875, 2007.

6)Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B'', (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.
Kobayashi S, Toyooka N, Zhou D, Tsuneki H, Wada T, Sasaoka T, Sakai H, Nemoto H, Garraffo HM,
Spande TF, Daly JW.
Beilstein J Org Chem, 3:30, 2007

7)Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients.
Usui I, Fujisaka S, Yamazaki K, Takano A, Murakami S, Yamazaki Y, Urakaze M, Hachiya H, Takata M, Senda S, Iwata M, Satoh A, Sasaoka T, Ak ND, Temaru R, Kobayashi M.
Diabetes Res Clin Pract, 77: 210-214, 2007.

8)Synthesis of poison-frog alkaloids and their pharmacological effects at neuronal nicotinic acetylcholine receptors.
Toyooka N, Tsuneki H, Kobayashi S, Dejun Z, Kawasaki M, Kimura I, Sasaoka T, Nemoto H.
Curr Chem Biol, 1: 97-114, 2007.