1）Alkaloids indolizidine 235B', quinolizidine 1-epi-207I and the tricyclic 205B are potent and selective non-competitive inhibitors of nicotinic acetylcholine receptors.
Tsuneki H., You Y., Toyooka N., Kagawa S., Kobayashi S., Sasaoka T., Nemoto H., Kimura I., Dani J.A.
Mol Pharmacol, 66: 1061-1069, 2004.

2）SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.
Sasaoka T., Wada T., Fukui K., Murakami S., Ishihara H., Suzuki R., Tobe K., Kadowaki T., Kobayashi M.
J Biol Chem, 279: 14835-14843, 2004.

3）Impact of src homology 2-containing inositol 5’-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.
Murakami S., Sasaoka T., Wada T., Fukui K., Nagira K., Ishihara H., Usui I., Kobayashi M.
Endocrinology 145: 3215-3223, 2004.

4）Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-ζ.
Ben-Romano R., Rudich A., Tirosh A., Potashnik R., Sasaoka T., Riesenberg K., Schlaeffer F., Bashan N.
Diabetologia, 47: 1107-1117, 2004.

5）Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans.
Tsuneki H., Ishizuka M., Terasawa M., Wu J.B., Sasaoka T., Kimura I.
BMC Pharmacol, 4:18, 2004.

6）Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells.
Tsuneki H., Ito K., Sekizaki N., Ma E-L., You Y., Kawakami J., Adachi I., Sasaoka T., Kimura I.
Biol Pharm Bull, 27: 1951-1956, 2004.

7）Nε-(carboxymethyl)lysine proliferated CD34+ cells from rat choroidal explant in culture.
Kobayashi S., Shinohara H., Tsuneki H., Nagai R., Horiuchi S.
Biol Pharm Bull, 27: 1382-1387, 2004.

8）Overproduction of Nε-(carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of streptozotocin-diabetic rat.
Kobayashi S., Suzuki M., Tsuneki H., Nagai R., Horiuchi S., Hagino N.
Biol Pharm Bull, 27: 1565-1571, 2004.

9）Cluster analysis of first-visit patients’ answers for Japanese-oriental Kampo questionnaire supporting the Empirical decision of Sho-syndrome.
Ishizuka M., Kita T., Katoh T., Tsuda M., Tosa H., Tsuneki H., Kimura I.
Kampo Med, 55: 347-354, 2004.

10) Absolute stereostructures of polypodane- and octanordammarane-type triterpenes with nitric oxide production inhibitory activity from guggul-gum resins.
Matsuda H., Morikawa T., Ando S., Oominami H., Murakami T., Kimura I., Yoshikawa M.
Bioorg Med Chem, 12:3037-3046, 2004.

11) Absolute stereostructures of polypodane-type triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resin (the resin of Balsamodendron mukul).
Matsuda H., Morikawa T., Ando S., Oominami H., Murakami T., Kimura I., Yoshikawa M.
Chem Pharm Bull, 52:1200-1203, 2004.