研究業績

【原著】

Tabuchi A, Ihara D.
Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF.
Front Mol Neurosci.2021 Nov 2;14:767842. (abstract)


Ishibashi Y, Shoji S, Ihara D, Kubo Y, Tanaka T, Tanabe H, Hakamata T, Miyata T, Satou N, Sakagami H, Mizuguchi M, Kikuchi K, Fukuchi M, Tsuda M, Takasaki I, Tabuchi A.
Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
J Neurochem. 2021 Nov;159(4):762-777. (abstract)


Mizukoshi M, Nozawa A, Oomizo S, Ihara D, Shiota J, Kikuchi K, Kaito M, Ishibashi Y, Ishikawa M, Fukuchi M,Tsuda M, Takasaki I, Tabuchi A.
Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells.
Biochem Biophys Res Commun. 2020 Aug 27;529(3):615-621. (abstract)


Miyata T, Kikuchi K, Ihara D, Kaito M, Ishibashi Y, Hakamata T, Yamada T, Ishikawa M, Mizukoshi M, Shoji S, Fukuchi M, Tsuda M, Hida Y, Ohtsuka T, Kaneda M, Tabuchi A.
Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
Biochem Biophys Res Commun. 2020 Jul 23;528(2):322-329. (abstract)


Fukuchi M, Okuno Y, Nakayama H, Nakano A, Mori H, Mitazaki S, Nakano Y, Toume K, Jo M, Takasaki I, Watanabe K, Shibahara N, Komatsu K, Tabuchi A, Tsuda M.
Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice.
Sci Rep. 2019 Aug 14;9(1):11833. (abstract)


Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A.
Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene.
J Neurochem. 2019 Jan;148(2):204-218. (abstract)


Kaneda M, Sakagami H, Hida Y, Ohtsuka T, Satou N, Ishibashi Y, Fukuchi M, Krysiak A, Ishikawa M, Ihara D, Kalita K, Tabuchi A.
Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.
Sci Rep. 2018 Jan 15;8(1):727. (abstract)


Ihara D, Fukuchi M, Katakai M, Shinoda Y, Katoh-Semba R, Furuichi T, Ishikawa M, Tabuchi A, Tsuda M.
Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways.
Cell Struct Funct. 2017 Oct 28;42(2):141-148. (abstract)


Kikuchi K, Shiota J, Yamada T, Ishikawa M, Ihara D, Fukuchi M, Tsuda M, Tabuchi A.
Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons.
Biochem Biophys Res Commun. 2017 Oct 21;492(3):474-479. (abstract)


Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Maehata Y, Tabuchi A, Tsuda M.
Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice.
Sci Rep. 2017 Jul 10;7(1):4949. (abstract)


Fukuchi M, Sanabe T, Watanabe T, Kubota T, Tabuchi A, Tsuda M.
Distinct regulation of activity-dependent transcription of immediate early genes in cultured rat cortical neurons.
Biochem Biophys Res Commun. 2017 Aug 26;490(3):682-687. (abstract)


Fukuchi M, Kuwana Y, Tabuchi A, Tsuda M.
Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons.
Genes Cells. 2016 Aug;21(8):921-9. (abstract)


Fukuchi M, Kanesaki K, Takasaki I, Tabuchi A, Tsuda M.
Convergent effects of Ca(2+) and cAMP signals on the expression of immediate early genes in neurons.
Biochem Biophys Res Commun. 2015 Oct 23;466(3):572-7. (abstract)


Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takemori H, Okuno H, Bito H, Tsuda M.
Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons.
J Neurosci. 2015 Apr 8;35(14):5606-24. (abstract)


Fukuchi M, Nakashima F, Tabuchi A, Shimotori M, Tatsumi S, Okuno H, Bito H, Tsuda M.
Class I histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor.
J Biol Chem. 2015 Mar 13;290(11):6825-36. (abstract)


Fukuchi M, Kirikoshi Y, Mori A, Eda R, Ihara D, Takasaki I, Tabuchi A, Tsuda M.
Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells.
J Neurochem. 2014 Jun (abstract)


Mizuguchi M, Fuju T, Obita T, Ishikawa M, Tsuda M, Tabuchi A.
Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1.
Sci Rep. 2014 Jun (abstract)


Ishikawa M, Shiota J, Ishibashi Y, Hakamata T, Shoji S, Fukuchi M, Tsuda M, Shirao T, Sekino Y, Baraban JM, Tabuchi A.
Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons.
Neuroreport.2014 May (abstract)


Takasaki I, Oose K, Otaki Y, Ihara D, Fukuchi M, Tabuchi A, Tsuneki H, Tabuchi Y, Kondo T, Saitoh A, Yamada M, Tsuda M.
Type II pyrethroid deltamethrin produces antidepressant-like effects in mice.
Behav Brain Res. 2013 Nov (abstract)


Ishikawa M, Shiota J, Ishibashi Y, Hakamata T, Shoji S, Fukuchi M, Tsuda M, Shirao T, Sekino Y, Ohtsuka T, Baraban JM, Tabuchi A.
Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1.
FEBS Open Bio. 2013 Sep (abstract)


Xu G, Shen J, Ishii Y, Fukuchi M, Dang TC, Zheng Y, Hamashima T, Fujimori T, Tsuda M, Funa K, Sasahara M.
Functional analysis of platelet-derived growth factor receptor-beta in neural stem/progenitor cells.
Neuroscience. 2013 May (abstract)


Matsuya Y, Ihara D, Fukuchi M, Honma D, Itoh K, Tabuchi A, Nemoto H, Tsuda M.
Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons.
Bioorg Med Chem. 2012 Apr (abstract)


Ihara D, Fukuchi M, Honma D, Takasaki I, Ishikawa M, Tabuchi A, Tsuda M.
Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter.
Neuropharmacology 2011 Nov (abstract)


Fukuchi M, Fujii H, Takachi H, Ichinose H, Kuwana Y, Tabuchi A, Tsuda M.
Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor.
Brain Res.2010 Dec 17;1366:18-26 (abstract)


Fukuchi M, Tsuda M.
Involvement of the 3'-untranslated region of the brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization.
J Neurochem2011 Dec;115(5):1222-33 (abstract)


Dong YX, Fukuchi M, Inoue M, Takasaki I, Tabuchi A, Wu CF, Tsuda M.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons.
Neurosci Lett.2010 Nov 5;484(3):174-7. (abstract)


Ishikawa M, Nishijima N, Shiota J, Sakagami H, Tsuchida K, Mizukoshi M, Fukuchi M, Tsuda M, Tabuchi A.
Involvement of the SRF coactivator megakaryoblastic leukemia in the activin-regulated dendritic complexity of rat cortical neurons.
J Biol Chem. 2010 Oct 22;285(43):32734-43 (abstract)


Ishimaru N, Fukuchi M, Hirai A, Chiba Y, Tamura T, Takahashi N, Tabuchi A, Tsuda M, Shiraishi M.
Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells.
Biochem Biophys Res Commun. 2010 Mar 26;394(1):173-7.(abstract)


Hara D, Miyashita T, Fukuchi M, Suzuki H, Azuma Y, Tabuchi A, Tsuda M.
Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons
Biochem Biophys Res Commun. 2009 Dec.18 ;390(3):648-53. (abstract)


Fukuchi M, Nii T, Ishimaru N, Minamino A, Hara D, Takasaki I, Tabuchi A, Tsuda M.
Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions.
Neurosci Res. 2009 Sep; 65(1):35-43. (abstract)


Hara D, Fukuchi M, Miyashita T, Tabuchi A, Takasaki I, Naruse Y, Mori N, Kondo T, Tsuda M..
Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF..
Biochem Biophys Res Commun. 2009 Jul 10 ;384(4):506-11. (abstract)


Takasaki I, Takarada S, Tatsumi S, Azegami A, Yasuda M, Fukuchi M, Tabuchi A, Kondo T, Tabuchi Y, Tsuda M.
Extracellular adenosine 5'-triphosphate elicits the expression of brain-derived neurotrophic factor exon IV mRNA in rat astrocytes.
Glia 2008 Oct;56(13):1369-79. (abstract)


Tabuchi A.
Synaptic plasticity-regulated gene expression: a key event in the long-lasting changes of neuronal function.
Biol Pharm Bull 2008 Mar;31(3):327-35. (abstract)


Yasuda M, Fukuchi M, Tabuchi A, Kawahara M, Tsuneki H, Azuma Y, Chiba Y, Tsuda M.
Robust stimulation of TrkB induces delayed increases in BDNF and Ark mRNA expression in cultured rat cortical neurons via distinct mechanisms
J Neurochem. 2007 Oct;103(2):626-36. (abstract)


Ishimaru N, Tabuchi A, Daichi H, Hayashi H, Sugimoto T, Tasuhara M, Shiota J, Tsuda M.
Regulation of neurotrophin-3 gene transcription by Sp3 and Sp4 in neurons.
J Neurochem. 2007 Jan;100(2):520-31. (abstract)


Shiota J, Ishikawa M, Sakagami H, Tsuda M, Baraban JM, Tabuchi A.
Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology
J Neurochem. 2006 Sep;98(6):1778-88. (abstract)


Imamura L, Yasuda M, Kuramitsu K, Hara D, Tabuchi A, Tsuda M.
Deltamethrin, a pyrethroid insecticide, is a potent inducer for the activity-dependent gene expression of BDNF in neurons.
J Pharmacol Exp Ther. 2006 Jan;316(1):136-43. Epub 2005 Sep 15. (abstract)


Fukuchi M, Tabuchi A, Tsuda M.
Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons.
J Pharmacol Sci. 2005 Jul;98(3):212-8. Epub 2005 Jul 9. (abstract)


Tabuchi A, Estevez M, Henderson JA, Marx R, Shiota J, Nakano H, Baraban JM.
Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.
J Neurochem. 2005 Jul;94(1):169-80. (abstract)


Miyashita T, Tabuchi A, Fukuchi M, Hara D, Kisukeda T, Shimohata T, Tsuji S, Tsuda M.
Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons.
Biochem Biophys Res Commun. 2005 Aug 12;333(4):1241-8. (abstract)


Imamura.L, Kurashina K, Kawahira T, Omoteno M, Tsuda M.
Additional repression of activity-dependent c-fos and BDNF mRNA expression by lipophilic compounds accompanying a decrease in Ca2+ influx into neurons.

Neurotoxicology. 2005 Jan;26(1):17-25.(abstract)


Fukuchi M, Tabuchi A, Tsuda M.
Activity-dependent transcriptional activation and mRNA stabilization for cumulative expression of PACAP mRNA controlled by calcium and cAMP signals in neurons.
J Biol Chem. 2004 Nov 12;279(46):47856-65.(abstract)


Fukuchi M, Sakuragawa S,Tabuchi A, Tsuda M.
Calcium signal-mediated expression of the vasoactiveintesrinal polypeptide gene and its smallcontribution to the activity-dependent survival of mousecerebellar granule cells
J Neurosci. Res. 2004 Jul 1;77(1):26-34.(abstract)


Tabuchi A, Ishii A, Fukuchi M, Kobayashi S, Suzuki T, Tsuda M.
Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons
Neuroreport. 2004 Jun 7;15(8):1329-33.(abstract)


Tabuchi A, Funaji K, Nakatsubo J, Fukuchi M, TsuchiyaT, Tsuda M.
Inactivation of aconitase during the apoptosis of mousecerebellar granule neurons induced by a deprivation of membrane depolarization.
J Neurosci Res. 2003 Feb 15;71(4):504-15.(abstract)


Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, Tsuda M.
Involvement of an upstream stimulatory factor as wellas cAMP-responsive element-binding protein in the activation of brain-derivedneurotrophic factor gene promoter I.
J Biol Chem. 2002 Sep 27;277(39):35920-31. (abstract)


Imamura L, Hasegawa H, Kurashina K, Matsuno T, TsudaM.
Neonatal exposure of newborn mice to pyrethroid (permethrin)represses activity-dependent c- fos mRNA expression in cerebellum.
 Arch Toxicol. 2002 Jul;76(7):392-7. (abstract)


Tabuchi A, Yamada T, Sasagawa S, Naruse Y, Mori N,Tsuda M.
REST4-mediated modulation of REST/NRSF-silencing functionduring BDNF gene promoter activation.
Biochem Biophys Res Commun. 2002 Jan 11;290(1):415-20.(abstract)


Tabuchi, A., Koizumi, M. and Tsuda, M.
Novel splice variants of PACAP gene in mouse cerebellargranule cells.
Neuroreport. 2001 May 8;12(6):1181-6.(abstract)


Tabuchi A, Koizumi M, Nakatsubo J, Yaguchi T,Tsuda M.
Involvement of endogenous PACAP expression in theactivity-dependent survival of mouse cerebellar granule cells.
Neurosci Res. 2001 Jan;39(1):85-93.(abstract)


Imamura L, Hasegawa H, Kurashina K, HamanishiA, Tabuchi A, Tsuda M.
Repression of activity-dependent c-fos and brain-derivedneurotrophic factor mRNA expression by pyrethroid insecticides accompanyinga decrease in Ca(2+) influx into neurons.
J Pharmacol Exp Ther. 2000 Dec;295(3):1175-82.(abstract)


Tabuchi A, Nakaoka R, Amano K, Yukimine M, AndohT, Kuraishi Y, Tsuda M.
Differential activation of brain-derived neurotrophicfactor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependentand N-methyl-D-aspartate receptor Ca2+ channels.
J Biol Chem. 2000 Jun 9;275(23):17269-75.(abstract)


Tabuchi A, Nakatani C, Nakaoka R, Naruse Y, KojimaT, Mori N, Tsuda M.
Silencer-mediated repression and non-mediated activationof BDNF and c-fos gene promoters in primary glial or neuronal cells.
Biochem Biophys Res Commun. 1999 Aug 2;261(2):233-7.(abstract)


Tabuchi A, Sano K, Nakaoka R, Nakatani C, Tsuda M.
Inducibility of BDNF gene promoter I detectedby calcium-phosphate-mediated DNA transfection is confined to neuronalbut not to glial cells.
Biochem Biophys Res Commun. 1998 Dec 30;253(3):818-23.(abstract)


Fujita Y, Katagi J, Tabuchi A, TsuchiyaT, Tsuda M.
Coactivation of secretogranin-II and BDNF genesmediated by calcium signals in mouse cerebellar granule cells.
Brain Res Mol Brain Res. 1999 Jan 8;63(2):316-24.(abstract)


Ichikawa D, Tabuchi A, Taoka A, Tsuchiya T,Tsuda M.
Attenuation of cell death mediated by membrane depolarizationdifferent from that by exogenous BDNF in cultured mouse cerebellar granulecells.
Brain Res Mol Brain Res. 1998 May;56(1-2):218-26.(abstract)



【和文総説】

神経活動依存的な遺伝子発現ネットワーク
津田正明、福地守、原大智、田渕明子
実験医学, 25, 180-185 (2007)


脳由来神経栄養因子BDNF
遺伝子発現制御系がシナプス可塑性に果たす役割
津田正明、原大智、安田誠、福地守、田渕明子
生化学, vol.78 No.10 998-1007 (2006)


アクチン結合蛋白質RPEL/MALファミリーの転写コアクチベーターとしての機能と細胞形態制御
田渕明子
生化学, vol.78 No.10 987-997 (2006)


脳由来神経栄養因子BDNFとくすり
津田正明、安田 誠、今村理佐、福地 守、田渕明子
脳21, Vol.8, No.3, 309-315 (2005)


記憶・学習における神経活動依存性遺伝子発現と殺虫剤によるかく乱
今村 理佐, 安田 誠, 田渕 明子, 福地 守, 津田 正明
BRAIN MEDICAL Vol.16 No.4  p63-68, 2004


脳由来神経栄養因子BDNFと記憶・学習
津田正明
ファルマシア, 39, 945-950 (2003)


神経細胞におけるカルシウム応答遺伝子群
津田正明、田渕明子
生化学71,、特集「神経細胞研究のおもしろさを語る」、515-520  (1999)


カルシウム依存的な神経細胞死抑制に関わる遺伝子群の発現
田渕明子、津田正明
医学のあゆみ、別冊「神経細胞死制御」、三須良貫、赤池昭紀 編、193-198(1998)


神経活動と遺伝子発現ー記憶の細胞過程解析に向けてー
津田正明、田渕明子、佐野訓明
蛋白質核酸酵素, 42 (4), 632-642 (1997)



【その他】
1. 神経細胞死抑制の分子機構
田渕明子
化学と工業, 53 (7) 827 (2000)