伊原 大輔 業績一覧


1. Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter.
    Ihara D, Fukuchi M, Honma D, Takasaki I, Ishikawa M, Tabuchi A, Tsuda M.
    Neuropharmacology. 2012 Feb;62(2):1091-8. doi: 10.1016/j.neuropharm.2011.10.023. Epub 2011 Nov 7.


2. Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons.
    Matsuya Y, Ihara D, Fukuchi M, Honma D, Itoh K, Tabuchi A, Nemoto H, Tsuda M.
    Bioorg Med Chem. 2012 Apr 15;20(8):2564-71. doi: 10.1016/j.bmc.2012.02.048. Epub 2012 Mar 3.


3. Type II pyrethroid deltamethrin produces antidepressant-like effects in mice.
    Takasaki I, Oose K, Otaki Y, Ihara D, Fukuchi M, Tabuchi A, Tsuneki H, Tabuchi Y, Kondo T, Saitoh A, Yamada M, Tsuda M.
    Behav Brain Res. 2013 Nov 15;257:182-8. doi: 10.1016/j.bbr.2013.09.044. Epub 2013 Sep 27.


4. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells.
    Fukuchi M, Kirikoshi Y, Mori A, Eda R, Ihara D, Takasaki I, Tabuchi A, Tsuda M.
    J Neurochem. 2014 Oct;131(2):134-46. doi: 10.1111/jnc.12801. Epub 2014 Jul 18.


5. Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons.
    Kikuchi K, Shiota J, Yamada T, Ishikawa M, Ihara D, Fukuchi M, Tsuda M, Tabuchi A.
    Biochem Biophys Res Commun. 2017 Oct;492(3):474-9. doi: 10.1016/j.bbrc.2017.08.071. Epub 2017 Aug 19.


6. Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways.
    Ihara D, Fukuchi M, Katakai M, Shinoda Y, Katoh-Semba R, Furuichi T, Ishikawa M, Tabuchi A, Tsuda M.
    Cell Struct Funct. 2017 Oct 28;42(2):141-8. doi: 10.1247/csf.17015. Epub 2017 Sep 23.


7. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.
    Kaneda M, Sakagami H, Hida Y, Ohtsuka T, Satou N, Ishibashi Y, Fukuchi M, Krysiak A, Ishikawa M, Ihara D, Kalita K, Tabuchi A.
    Sci Rep. 2018 Jan 15;8(1):727. doi:10.1038/s41598-017-18905-7. Epub 2018 Jan 15.


8. Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene.
    Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A.
    J Neurochem. 2019 Jan;148(2):204-218. doi: 10.1111/jnc.14596. Epub 2018 Nov 12.


9. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
    Miyata T, Kikuchi K, Ihara D, Kaito M, Ishibashi Y, Hakamata T, Yamada T, Ishikawa M, Mizukoshi M, Shoji S, Fukuchi M, Tsuda M, Hida Y, Ohtsuka T, Kaneda M, Tabuchi A.
    Biochem Biophys Res Commun. 2020 Jul;528(2):322-329. doi: 10.1016/j.bbrc.2020.05.006. Epub 2020 May 15.


10. Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells.
    Mizukoshi M, Nozawa A, Oomizo S, Ihara D, Shiota J, Kikuchi K, Kaito M, Ishibashi Y, Ishikawa M, Fukuchi M,Tsuda M, Takasaki I, Tabuchi A.
    Biochem Biophys Res Commun. 2020 Aug 27;529(3):615-621. doi: 10.1016/j.bbrc.2020.06.064. Epub 2020 Jul 18.


11. Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
    Ishibashi Y, Shoji S, Ihara D, Kubo Y, Tanaka T, Tanabe H, Hakamata T, Miyata T, Satou N, Sakagami H, Mizuguchi M, Kikuchi K, Fukuchi M, Tsuda M, Takasaki I, Tabuchi A.
    J Neurochem. 2021 Nov;159(4):762-777. doi: 10.1111/jnc.15122. Epub 2020 Jul 31.


12. Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF. [Review]
    Tabuchi A, Ihara D.
    Front Mol Neurosci. 2021 Nov 2;14:767842. doi: 10.3389/fnmol.2021.767842. eCollection 2021.


13. SRF in Neurochemistry: Overview of Recent Advances in Research on the Nervous System. [Review]
    Tabuchi A, Ihara D.
    Neurochem Res. 2022 Sep;47(9):2545-2557. doi: 10.1007/s11064-022-03632-x.


14. SRF and SRF cofactor mRNA expression is differentially regulated by BDNF stimulation in cortical neurons.
    Ihara D, Miyata T, Fukuchi M, Tsuda M, Tabuchi A..
    Biol Pharm Bull. 2023 Apr 1;46(4):636-639. doi: 10.1248/bpb.b22-00825.


15. The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons.
    Nakayama H, Ihara D, Fukuchi M, Toume K, Yuri C, Tsuda M, Shibahara N, Tabuchi A..
    J Nat Med. 2023 Jun;77(3):584-595. doi: 10.1007/s11418-023-01703-z.


16. Endogenous SOLOIST/MRTFB i4, a neuronal isoform of MKL2/MRTFB, positively and negatively regulates SRF target immediate early genes in Neuro-2a cells.
    Ihara D, Tanabe H, Takasaki I, Tabuchi A..
    Biol Pharm Bull. 2023 Aug 1;46(8):1141-1144. doi: 10.1248/bpb.b22-00851.


17. Enhancing c-fos mRNA Expression in Primary Cortical Cell Cultures with a Dynamic Magnetic Fields Device.
    Shibata T, Ihara D, Kirihara Y, Yagi T, Tabuchi A, Kuroda S..
    IEEJ Transactions on Electrical and Electronic Engineering. 2023 Dec;18:1932-1938. doi: 10.1002/tee.23914.


18. Brain-derived neurotrophic factor (BDNF) downregulates mRNA levels of suppressor of cancer cell invasion (SCAI) variants in cortical neurons.
    Ihara D, Mizukoshi M, Tabuchi A..
    Genes Cells. 2024 Jan;29(1):99-105. doi: 10.1111/gtc.13086.